Ewan MacDonald
@EwanMac10292433
Cell biologist NCBS-Instiute Curie reaserch fellow.
nature.com/articles/s4146… POTATOMap is officially out today (even tho it says 2024-12-30)… long story 😂 Constructs are available on addgene and POTATOMap data is available on PRIDE repository. Thank you so much to everyone involved!!
It's out!😭🕺First preprint as a PhD at the Farias Lab @ginny_farias where we investigated biosynthetic lysosomal membrane protein trafficking, delivery and interactome with Protein Origin, Trafficking And Targeting to Organelle Mapping (POTATOMap)🥔 biorxiv.org/content/10.110…
📢JOB CALL Last week to apply for a postdoc position at the IJM, Paris! If you're interested in membrane biology, the evolution of the extracellular matrix secretory apparatus, or protein secretion, come work with us! emploi.cnrs.fr/Offres/CDD/UMR…
Postdoc position! We're a new research group at @IJMonod, Paris, interested in the cellular secretory landscape and its re-organisation during fibrosis. Join us, and play a central role in shaping our vision in the coming years! DM/email for questions emploi.cnrs.fr/Offres/CDD/UMR…
🚨 New review out! We explore how extracellular acidification shapes key processes like endocytosis, neurotransmission & immune responses — and highlight tools to study it. 📖 Read more [doi.org/10.1016/j.ceb.…] w/ amazing collaborators 🙌 #CellBiology #Endocytosis #GPCR
My choice this week in @ScienceMagazine nature.com/articles/s4155…
Our latest publication in @ScienceAdvances is officially out! Here, we target the NPY/NPY1R signalling axis to lessen metastatic burden of mutant p53-dependent #PancreaticCancer 🔬👩🏼🔬 Check it out here: science.org/doi/10.1126/sc… @GarvanInstitute @Timpson_Lab
🔥🔬"Measuring plasma membrane fluidity using confocal microscopy" in @NatureProtocols🔬🔥 doi.org/10.1038/s41596… Thanks to the authors for the detailed protocol! @carravilla_p @SuperSphingoJan @EllenSjule @f_ragaller @BioSciFlo @CenkGurdap @SychTaras @Sciezgin
I'm excited to see our work online! EGF regulation of clathrin-independent endocytosis, via an elegant pH sensitive mechanism. Thank you to all for making it a great project to work on! #AcademicTwitter nature.com/articles/s4155… @institut_curie @EwanMac10292433 @CessVala @3i_inc
Thrilled to share our latest publication! We describe a novel acid-dependent mechanism regulating clathrin-independent endocytosis. This study was a fantastic collaborative effort with the labs of Ludger Johannes, Roberto Weigert, and Satyajit Mayor. nature.com/articles/s4155….
Happy to contribute to the analysis of β1integrin endocytosis using @3i_inc LLSM, now in @NatureCellBio rdcu.be/eaLM9 @LeconteLudovic C. Wunder @AlisonForreste3 @JeanSalamero @EwanMac10292433 Johannes team @institut_curie @Inria_Rennes @Fr_BioImaging #bioimageanalysis
New paper from the lab🎈. Introducing Micro Immune Response On-chip (MIRO), a device that replicates tumors and their microenvironment to better understand responses to immunotherapies (cyan=immune cells, red=cancer, green=CAFs). @IBECBarcelona
A nice story from @JKlumperman lab. Role of Vps41 in the recruitment of biosynthetic LAMP. Check out 👇
Sanzà, Klumperman et al. @UMCUtrecht reveal a novel role of VPS41 in cellular trafficking, showing that it recruits biosynthetic LAMP carriers in a process dependent on the small GTPase Arl8b. hubs.la/Q035q9D-0 #Organelles #Trafficking
#DDIndia - Government taking major steps to boost women’s participation in STEM: @DrJitendraSingh @karandi65 @DBTIndia @CSIR_IND @moesgoi #WomenInSTEM ddindia.co.in/2025/02/govern…
New review on structural glycobiology in glycosciences: "From enzymes to organelles". Carbohydrate processing enzymes, glycosylation networks in vitro, cryo-ET in direct visualisation of native biology. tinyurl.com/4jnv85xt #glycotime
Schematic diagram summarizing how STING and additional CASM-inducing stimuli result in the lysosomal recruitment and activation of LRRK2 in a GABARAP-dependent manner. From @abentleydesousa, Roczniak-Ferguson, and @Shawn__Ferguson @YaleMed: hubs.la/Q032Hrh50 #Lysosomes
Check out our latest review on flotillins! doi.org/10.1111/boc.20…
A beautiful and crisp reductionist approach to show the mechanism by which high affinity binding to lipids mediates cellular update. All you need is tight binding!
Paper out: Gene encoded nanoparticles (GEMs) with 180 GFPs are cool tools to track in cells. GEMs reveal biophysical basis of infection, too. Using GPI-anchored nanobody receptors over 6 logs of affinity shows that adhesion energy alone explains uptake! rdcu.be/dFddO
On my way to Sete for what promises to be three days of amazing science. Looking forward to lots of fun discussions and to meeting science friends - old and new. #ExoEndo
In recognition of Rare Disease Day, we stand with those bravely confronting Rare disorders. Our mission is to amplify their voices and foster a society that fully embraces the Rare disease community.
#MembraneTrafficking seminars are back in 2024! Join @felixmendu @Fran_Bottanelli and me next week for two exciting talks. Looking forward to seeing you membrane enthusiasts again! Feb 29, 5.00pm CET, 11.00am ET