Jon Humphries
@JDHL18
Bioscience, Manchester Metropolitan University. Cell adhesion, proteomics, ECM. Tweets (not posts) mainly science.
Very belatedly I've decided to pause posting here. You can find me and my posts where the skies are blue...
It's a New Year but the signs of melanoma skin cancer are the same. 📆 Make monthly skin checks one of your 2025 resolutions and get to know the signs. 🔎 Skin & Nail Check Leaflet 👉 buff.ly/3N6K3nZ #melanoma #signsofskincancer #skincancersigns
#PLOSONE: THUMPD3 regulates alternative splicing of ECM transcripts in human lung cancer cells and promotes p ... dx.plos.org/10.1371/journa…
Targeting extracellular matrix stiffness for cancer therapy frontiersin.org/journals/immun…
FAK activity exacerbates disturbed flow-mediated atherosclerosis via VEGFR2-Cbl-NF-κB signaling biorxiv.org/content/10.110…
FAK and p130Cas Modulate Stiffness-Mediated Early Transcription and Cellular Metabolism onlinelibrary.wiley.com/doi/10.1002/cm…
ITGB4-Related pyloric atresia without epidermolysis in two siblings sciencedirect.com/science/articl…
Emergence of the cell-matrix adhesion element ILK as a player in glioblastoma cell plasticity. sciencedirect.com/science/articl…
Collagen signaling and matrix stiffness regulate multipotency in glandular epithelial stem cells in mice nature.com/articles/s4146…
Review Integrins as Drug Targets in Vascular and Related Diseases sciltp.com/journals/ijddp…
JCI Insight - Talin1 dysfunction is genetically linked to systemic capillary leak syndrome insight.jci.org/articles/view/…
The kinesin KIF3AC recycles endocytosed integrin to polarize adhesion formation towards the leading edge biorxiv.org/content/10.110…
This week the Guardian's owner, the Scott Trust, gifted the 233-year-old Observer to Tortoise Media. This isn't just a dark day for journalism, it's a sign. Meet the team. This is Putin giving Tortoise's energy advisory board member an 'Order of Friendship' medal in 2017. 1/
FAK inhibition suppresses breast cancer progression via DNA methylation-mediated DAB2 gene reactivation biorxiv.org/content/10.110…
It's a busy time of the year but don't put off checking your skin! Getting to know your skin & monitoring any changes, lesions & moles can help you spot the early signs of skin cancer. If you are concerned about a mole or lesion, please contact your GP. buff.ly/3N6K3nZ
Sending our best wishes to @JulianLennon at this time. Thank you for using your platform to raise vital awareness and highlighting the importance of regularly checking your skin. About melanoma: buff.ly/3xgMyyn FREE skin and nail check leaflet: buff.ly/3N6K3nZ
🫣 Disturbing Images…. Hi Folks, Well, here’s how this goes… Before I flew to New York from Los Angeles, for good morning America , Sirius XM, iHeart Radio & My Fotografiska Q&A Book Signing Event, I went to see, as I usually do when in LA, My lovely Dermatologist - Dr Tess,…
Our study recruiting now! Using ctdna to guide whether to have systemic treatment in early stage melanoma - amazing response from UK to get this q addressed- we already have 7 sites open in the first month and our first patient randomised! @CR_UK funded 🎉🎉
The Detection-2 feasibility study is now open looking at using a ctDNA blood test to guide treatment for patients with high-risk stage 2B/2C/3A cutaneous melanoma who have had surgery to remove it. It will be open for 1year in at least 8centres across the UK
Another important contribution to our Special Issue on Integrins in Matrix Biology
The formin FMNL2 plays a role in the response of melanoma cells to substrate stiffness biorxiv.org/content/10.110…
Why probability probably doesn’t exist (but it is useful to act like it does) nature.com/articles/d4158…
