Daniel J Drucker

Some new information about the anti-inflammatory actions of GIP from @RolaHammoud1 Gain and loss of GIPR signaling modifies gut inflammation in mice with 5FU-induced enteritis, with data on Tirzepatide & Semaglutide @JCI_insight @BBDC_UofT @SinaiHealth @CIHR_IRSC

Understanding disulphide bond shuffling is crucial for developing strategies to mitigate #insulin aggregation, thereby improving the therapeutic management of #diabetes nature.com/articles/s4146…

In 104 teduglutide-treated children with #shortbowelsyndrome a clinical response was detected in 70% and.complete weaning from parenteral nutrition was achieved in 22% thelancet.com/journals/eclin…

Lipidema and exenatide- 5 cases mdpi.com/2039-7283/15/7…

A retrospective cohort study suggests that GLP-1RA use may reduce the both the risk and progression of AMD and progression of early and intermediate AMD to advanced AMD in adults with #T2D journals.lww.com/retinajournal/…

For patient safety, clinicians in the U.S. should have the option to prescribe multi dose injectors for tirzepatide and semaglutide. Why do other countries have these options but the U.S. only has the autoinjectors? @novonordiskus @EliLillyandCo

The proteomic blueprint of #aging across 13 human tissues cell.com/cell/abstract/…

Fasting, metabolism #longevity and health. Benefits, risks and unknowns academic.oup.com/edrv/advance-a…

PVH and SON Oxytocin neurons differentially modulate food intake by either reducing or increasing caloric consumption, respectively.@MolMetab sciencedirect.com/science/articl…

In the SUMMIT trial greater weight loss on treatment with tirzepatide was associated with greater improvements in 6MWD and KCCQ in HFpEF #obesity jacc.org/doi/10.1016/j.…

Preclinical data reveal that dietary fat sources differentially regulate natural killer and CD8 T cell infiltration and function within the tumour microenvironment, governed by distinct effects on the plasma metabolome and intracellular metabolism. nature.com/articles/s4225…

A multi-tissue atlas of #exercise induced endocrine interactions in rats, serving as a resource for novel exerkine discovery and mechanistic investigation. sciencedirect.com/science/articl…

A flagellin Toll-like receptor 5 (TLR5) peptide YY (PYY)-labelled colonic neuropod cell axis leads to PYY release onto NPY2R vagal nodose neurons to regulate feeding nature.com/articles/s4158…

Adipose tissue-derived mesenchymal stromal/stem cells (ADMSCs) represent a novel therapeutic intervention for Type 1 #Diabetes (T1D). An update @commsbio nature.com/articles/s4200…

Exciting preclinical studies demonstrate that the Glia-derived peptide Octadecaneuropeptide may be valuable for targeting weight and glycemic control via the hindbrain without eliciting the common treatment side effects seen with GLP-1 receptor agonists science.org/doi/10.1126/sc…

A new online resource of GPCR drugs, clinical trial agents, targets and disease indications nature.com/articles/s4438…

WAT-derived N-acetylaspartate (NAA) is an endocrine regulator of postprandial body temperature with broader roles for metabolic homeostasis. nature.com/articles/s4225…

Here Tony Lam and colleagues @UHN identify that lipid sensing in HFD-fed rats is enhanced by metformin to trigger an endocrine GIP to NTS GIPR axis to reduce food intake unveiling potential targets to enhance GIP action and reduce weight in #obesity diabetesjournals.org/diabetes/artic…

Does Tirzepatide improve #insulin sensitivity independent of #weightloss ? link.springer.com/article/10.100… @DiabetologiaJnl

A REV-ERBα mechanism by which the liver contributes to peripheral tissue wasting in #cancer cachexia, offering perspectives for future therapeutic interventions cell.com/cell/fulltext/…?

RESEARCH | @clarissamliu, @DanielJDrucker, M Véniant et al (@Amgen, @SinaiHealth) Part 1: This study and a co-pub delve into how both GIP receptor agonists and antagonists trigger weight loss through different mechanisms. nature.com/articles/s4225…