Gerta Hoxhaj Lab

Excited to receive an NIH K08 Clinical Investigator Award to support my research on #mitochondria #peroxisomes 😀 The $775K will be critical in helping me transition to independence as I begin looking for a place to start my lab 🙏🏻 @A_P_S_A @the_asci @AmerAcadPeds #neotwitter

Why do some genetic mutations devastate specific tissues while sparing others? We explore this question in GGC repeat disorders, revealing a mechanism linking protein aggregation to tRNA splicing failure in the brain. 🧵 on our new paper in Science: 🔗 science.org/doi/10.1126/sc…

Discovery that the NRBP1 pseudo-kinase activates the WNK Pathway ppu.mrc.ac.uk/news/discovery… @ScienceMagazine

Intro to 2 new studies from my lab on somatic mutations in liver disease. 1st is about a mutated gene that leads to improved clone fitness and organismal health (CIDEB). The 2nd is about a mutated gene that leads to improved clone fitness but worse overall health (TBX3). 1/8

New preprint w/ the Dupage lab! FSP1 KO in Tregs / Tcells promotes tumor suppression, highlighting the therapeutic value & single-agent potential of FSP1 inhibition. A new paradigm for targeting ferroptosis in the immune system (not just in cancer cells). biorxiv.org/content/10.110…

Just published: nature.com/articles/s4158… Coenzyme Q10 (CoQ10) is critical for mitochondrial function and for controlling reactive oxygen species damage to biological membranes. Because CoQ10 is poorly bioavailable, new approaches are needed to promote CoQ10 synthesis. In our…

With @katerinarohlena pleased to announce the 2026 Prague Metabolism and Signaling Meeting (June 24-27). Two Keynotes (Vousden & Hall) and 30+ speakers in metabolism, mitochondria, aging, mTOR, & more. Please RT. Info, registration, & student discounts at: praguemetabolismsymposium.com

UT Southwestern is ranked #1 globally in the Nature Index for high-quality research in biological sciences! 🌎🔬 Proud to contribute to this culture of innovation at #UTSWDerm. 🔗nature.com/nature-index/i… #ResearchExcellence #DermatologyResearch

Great story: Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models aacrjournals.org/cancerres/arti…

Momentous day for CRI DeBerardinis Lab postdoc & @utswpediatrics Neonatologist @WalterWChen1 🎉 recipient of a 2025 @BWFUND Career Award for Medical Scientists! 👏👏 He will continue his #relentlessdiscovery studying uncharacterized organellar proteins ⬇️ cri.utsw.edu/deberardinis-l…

My lab's first paper is out in @Nature. We show that lipoprotein uptake protects tumors from ferroptosis by delivering the lipid antioxidant α-tocopherol. Surprisingly, tumors use sulfated glycosaminoglycans—not canonical receptors—to capture lipoproteins. nature.com/articles/s4158…

Excited to share our @Scintillon @scrippsresearch latest work “A genetically encoded bifunctional enzyme mitigates redox imbalance and lipotoxicity via engineered Gro3P-Glycerol shunt”: biorxiv.org/content/10.110… When we started working with NADH reductive stress (elevated…

Excited to share our latest study from the Manning Lab. We have developed and characterized a novel mouse model lacking the five AKT phosphorylation sites on the TSC2 protein, which are critical for AKT-mediated activation of mTORC1 signaling.

Thrilled to share that our latest study is now published in @Nature! Grateful to our amazing collaborators at @gshlab and @MET_HSPH. nature.com/articles/d4158… nature.com/articles/s4158…

Congratulations to @RenataG81952725 and everyone who contributed to this amazing work! CoQ imbalance drives reverse electron transport to disrupt liver metabolism nature.com/articles/s4158… @ghotamis @Harvard @HarvardChanSPH @MET_HSPH

We are hiring! The Ardehali lab at @UAZHeart and @UAZMedTucson is hiring postdocs and technicians. Our research focuses on metabolism, Immunology, iron biology and cardiovascular disease. Interested applicants can contact me directly.

I discuss the urgent crisis from the loss of federal support of science in the US and recent clinical gene editing breakthroughs with @WalterIsaacson & @amanpour on @AmanpourCoPBS, airing on @PBS tonight at 11 pm ET, and on @cnni earlier today. Pls share! youtube.com/watch?v=8YhJM6…

"We need really bright people and we need bold ideas." We're all in on making a proven positive impact. With the V Foundation, 100% of direct donations go to the best researchers and their revolutionary ideas. #NationalCancerResearchMonth

Online today in @Nature - our latest study led by superstar postdoc @GillesRademaker detailing the role of PSCK9 in driving sterol dependent metastatic organ choice in pancreatic cancer nature.com/articles/s4158… full text available here 👉 rdcu.be/em0VG and thread 👇

Thrilled to share that my main postdoctoral project in Josh Rabinowitz’s lab is out today at @CellCellPress! We found an unexpected, diet- and microbiota-dependent mechanism that affects the anticancer activity of PI3K inhibitors. Thread below👇