David M. Sabatini
@DMSabatini
Studying rapamycin and mTOR and metabolism for a long time.
Congratulations to you and everyone involved!!!
In this study, we generated a Slco1c1-CreERmouse line (Slco1c1-KI-P2A-iCreERT2, briefly, Slco1c1-CreERKI). Our staining results validate its high specificity for labeling CNS endothelial cells, with rare expression in peripheral endothelial cells. nature.com/articles/s4146…
Congrats, Shun on getting this out! We are very excited about this story which shows experience dependent plasticity of the effective sign of GABA/glutamate co-releasing synapses. The process is related to rapid experience/action outcome dependent updating of dopamine signaling
Can synapses in the brain switch their signs between excitatory and inhibitory during learning🚦? Can they act more like weights in artificial neural networks, able to switch signs based on experience 🔃? Excited to share my thesis work in @blsabatini lab! 🧵 ⬇️ (1/13)
Congratulations Raghu and Jason and team. Fantastic first paper from your lab. Opens many doors!!
Why do some genetic mutations devastate specific tissues while sparing others? We explore this question in GGC repeat disorders, revealing a mechanism linking protein aggregation to tRNA splicing failure in the brain. 🧵 on our new paper in Science: 🔗 science.org/doi/10.1126/sc…
Why do some genetic mutations devastate specific tissues while sparing others? We explore this question in GGC repeat disorders, revealing a mechanism linking protein aggregation to tRNA splicing failure in the brain. 🧵 on our new paper in Science: 🔗 science.org/doi/10.1126/sc…
Proudly presenting Simon’s paper on asymmetric apportioning of old mitochondria biasing intestinal stem cells for the Paneth cell linage through aKG-dependent metabolism @NatMetabolism nature.com/articles/s4225… @helsinkiuni @HiLIFE_helsinki @SuomenAkatemia @MetaStem_Center
Excited to share my first post-doc paper! Here, we make headway in understanding how metazoans regulate the pH of their organelles. Turns out, there exists a heterotrimeric complex required for V-ATPase assembly. We delve into the mechanism of this chaperone. Stay tuned for more!
New online! A heterotrimeric protein complex assembles the metazoan V-ATPase upon dissipation of proton gradients bit.ly/3GjrXRN
Congratulations @MichaelPacold and team. A wonderful example of basic science directly and quickly impacting disease therapy.
Just published: nature.com/articles/s4158… Coenzyme Q10 (CoQ10) is critical for mitochondrial function and for controlling reactive oxygen species damage to biological membranes. Because CoQ10 is poorly bioavailable, new approaches are needed to promote CoQ10 synthesis. In our…
Child walks again after experimental treatment for genetic condition | STAT statnews.com/2025/07/09/nyu…
Just published: nature.com/articles/s4158… Coenzyme Q10 (CoQ10) is critical for mitochondrial function and for controlling reactive oxygen species damage to biological membranes. Because CoQ10 is poorly bioavailable, new approaches are needed to promote CoQ10 synthesis. In our…
With @katerinarohlena pleased to announce the 2026 Prague Metabolism and Signaling Meeting (June 24-27). Two Keynotes (Vousden & Hall) and 30+ speakers in metabolism, mitochondria, aging, mTOR, & more. Please RT. Info, registration, & student discounts at: praguemetabolismsymposium.com
I left a top academic research job after 200+ publications, world-leading discoveries, and some of the highest citation metrics in my field. What happened to me wasn’t about science. It was about power, fear, and a system that punishes truth. 🧵 1/
📣Don't forget to register and submit your abstract for short talk consideration at #RedoxBio25 The chairs would love to have you on board and look forward welcoming some new and familiar faces in sunny Mexico. 🇲🇽🌞 To Register and Submit your abstract: bit.ly/45Qk3tb
Excited to share our latest study from the Manning Lab. We have developed and characterized a novel mouse model lacking the five AKT phosphorylation sites on the TSC2 protein, which are critical for AKT-mediated activation of mTORC1 signaling.
Online now: AKT-mediated phosphorylation of TSC2 controls stimulus- and tissue-specific mTORC1 signaling and organ growth dlvr.it/TLBR9Q
Excited to unveil Boltz-2, our new model capable not only of predicting structures but also binding affinities! Boltz-2 is the first AI model to approach the performance of FEP simulations while being more than 1000x faster! All open-sourced under MIT license! A thread… 🤗🚀
Exactly. Even colleagues who are close friends have the human SIM card removed, and the Admin SIM card inserted, when they take on an Admin role - they can then easily help thrust you into Dante's 9th circle with no remorse or feeling. Living that nightmare myself.
When I interviewed for faculty positions in the early 2010s, I was told there are three components of the job – research, teaching and service. The service consisted of performing tasks to help out with university function. The idea was that the university acted as a sort of…