Fitzpatrick Laboratory
@FitzpatrickLab
Assistant Professor @ZuckermanBrain @ColumbiaBiochem. Lab uses cryo-EM & biophysics to study the cellular, molecular, and structural basis of neurodegeneration.
New preprint from @DuXDaniel @FitzpatrickLab shows #femtosecond light pulses can lens electron beams, promising higher contrast in #cryoET and better aberration correction in #cryoEM biorxiv.org/content/10.110… Experiments made possible by support from @cziscience #ImagingTheFuture
Excited to share our new paper out in @Nature revealing cell-type specific nuclear organization and its link to gene regulation using new spatial multi-omics technologies! nature.com/articles/s4158…
Online now! Automated identification of small molecules in cryoelectron microscopy data with density- and energy-guided evaluation dlvr.it/TM6fxv
Structural insights into brain thyroid hormone transport via MCT8 and OATP1C1: Cell cell.com/cell/abstract/…
Synaptic loss pattern is constrained by brain connectome and modulated by phosphorylated tau in Alzheimer’s disease nature.com/articles/s4146…
Forward-looking preview by @WUBin10069342 to our latest paper @Structure_CP by @AndrewNChang highlighting the power of #AI in #cryoEM of patient-derived samples: tinyurl.com/tu2fyvme Paper: tinyurl.com/3cycffzm Thanks to @pixelbaumarkt @Intein for #crYOLO, & @cryosparc
Neuroinflammation across neurological diseases @ScienceMagazine science.org/doi/10.1126/sc…
Online now! Structural basis of human uromodulin filament networks in uropathogen capture dlvr.it/TKdsLM
Over 20 years ago, Zuker et al. discovered the mammalian sweet taste receptors Now, an exciting collaboration between our labs @ColumbiaBiochem reveals the #cryoEM structure of the human sweet receptor-key to sweet taste perception-online @CellCellPress! sciencedirect.com/science/articl…
You want to start tomography? Solve structures inside cells? Reach Nyquist😳? We have a website for you! tomoguide.github.io You'll find a tutorial on how to reconstruct tomograms, pick particles and do subtomo averaging, using different software! Hope it will be useful !
New online! Gating mechanism of the two-pore-domain potassium channel THIK1 bit.ly/435XgI6
Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing: nature.com/articles/s4146…
Important discovery by @sabrina_absalon and team!
Humble for the spotlight on our newest preprint, only possible with the hard work of a whole team of amazing scientists @James_Blauwkamp @RajaramKrithika @StellaYSun Sophia Staggers Oli Harrigan contagionlive.com/view/discovery… via @contagionlive
Nature research paper: Structural basis of lipid transfer by a bridge-like lipid-transfer protein go.nature.com/4itODM4
Exciting paper in @naturemethods that pushes the boundaries of MSI and spatially-resolved omics🥳TEMI reaches single-cell spatial resolution and enables the profiling of hundreds of lipids, metabolites, peptides, and N-glycans in complex tissue. Check out: rdcu.be/eiIWy
2025 Canada Gairdner Award Winners Announced gairdner.org/resource-hub/2… Congrats to BMB faculty member Iva Greenwald, and mentor of many BMB scientists Gary Struhl for this tremendous honor!
Today we report in @NatureMedicine the development of a base editing strategy for prion disease, currently a fatal and rapidly progressing neurogenerative condition with no effective treatment. @PrionAlliance @DevermanLab (1/13) drive.google.com/file/d/1DVpKrz…
Excited to share our pre-print on the molecular architecture of heterochromatin in human cells🧬🔬 w/ @jpkreysing, Johannes Betz,Turoňová lab, @MarinaLusic, Hummer lab, @Beck_Laboratory, @MPIbp 🔗 Preprint here: doi.org/10.1101/2025.0…
PTM-Mamba: a post-translational modification-aware protein language model, for protein modeling and design. nature.com/articles/s4159…
Our April issue is live! 🌧️🌷 nature.com/nmeth/volumes/… On the cover, Spotiphy projects scRNA-seq and histological image data onto the spatial transcriptome. Artwork by Jiyuan Yang @StJudeResearch. Paper: nature.com/articles/s4159…