John Lukens
@LukensJohnR
Neuroimmunologist studying MS, autism, Alzheimer's disease, and brain injury at the University of Virginia. Father of two. Fan of Philly sports and US soccer.
G-protein-coupled receptor ADGRG1 drives a protective microglial state in Alzheimer's disease through MYC activation @NeuroCellPress cell.com/neuron/fulltex…
🔬 At UVA, our researchers are turning bold ideas into better health, from pioneering artificial pancreas technology to exploring the brain-immune system connection. See how we're transforming medicine: med.virginia.edu/research/
Mast cells regulate the brain-dura interface and CSF dynamics @CellCellPress cell.com/cell/fulltext/…
LR5:flagellin stimulates colonic neuropod cells to reduce feeding through a gut–brain sensory neural circuit @Nature nature.com/articles/s4158…
TLR5:flagellin stimulates colonic neuropod cells to reduce feeding through a gut–brain sensory neural circuit @Nature nature.com/articles/s4158…
Cell-type-directed network-correcting combination therapy for Alzheimer’s disease: @CellCellPress cell.com/cell/fulltext/…
We are #hiring! Please RT! If you have a PhD, are passionate about aging research, and curious about other disciplines than your own, consider joining the journal’s editorial team. springernature.wd3.myworkdayjobs.com/SpringerNature…
Using newly developed mouse models and a microglia replacement strategy, researchers in Science show that bone marrow transplantation could be used as an effective therapy for ALSP, a rare and fatal neurodegenerative disease. 📄: scim.ag/4kW4jsR #SciencePerspective:…
Accelerating biomedical discoveries in brain health through transformative neuropathology of aging and neurodegeneration @NeuroCellPress cell.com/neuron/fulltex…
Type 2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven host defense @ScienceMagazine science.org/doi/10.1126/sc…
APOE ε4 carriers share immune-related proteomic changes across neurodegenerative diseases @NatureMedicine nature.com/articles/s4159…
The kinase RIPK3 suppresses pathologic neuroinflammation in mouse models of flavivirus infection @scisignal @briandanielsli science.org/doi/10.1126/sc…
Cognate interaction-dependent pathogenicity of meningeal B cells drives neuroinflammation relapse @immunity cell.com/immunity/fullt…
Dr. John Lukens @LukensJohnR of University of Virginia, who completed the Introductory Course in #Immunology when he was a graduate student, kicked off Day 5 of the 2025 Intro Course with a deep dive lecture on neuroimmunology — where the immune system intersects with the central…
Insights by Mangalmurti and @LukensJohnR: Yang et al (hubs.la/Q03x3Y_60) provide an exhaustive study of a novel mouse model of NGLY1 deficiency, a devastating neurological disease, & implicate the cGAS-STING pathway in mediating key disease features hubs.la/Q03x3Yxx0
Response of spatially defined microglia states with distinct chromatin accessibility in a mouse model of Alzheimer’s disease nature.com/articles/s4159…
My lab is recruiting! We study respiratory immunology, chronic lung diseases and aging. Come join us @UVAimmunology at the beautiful UVA campus and Charlottesville. Please help spread the words.
Taking the STING out of neurodegenerative disease rupress.org/jem/article/22…
Microglia replacement halts the progression of microgliopathy in mice and humans | @ScienceMagazine science.org/doi/10.1126/sc…
Glymphatic dysfunction in Alzheimer’s disease: A critical appraisal | @ScienceMagazine science.org/doi/10.1126/sc…