Filip Nemcko
@FilipNemcko
Staff scientist at @stark_lab, @IMPvienna, @viennabiocenter
Excited to share our collaborative project at the @viennabiocenter, introducing ORFtag—a new method to advance protein function studies. Learn more in the interview and the linked paper. 🧬
Our @FilipNemcko co-developed ORFtag–a new method that makes it easier to study the function of proteins by mass tagging and tracking them across the entire genome. Read about this @viennabiocenter-wide collaboration in the interview with Filip: imp.ac.at/news/article/o…
How do enhancers work over distances that sometimes exceed megabases? Excited to share our work led by @gracecbower where we uncover a unique sequence signature globally associated with long-range enhancer-promoter interactions in developing limb buds: biorxiv.org/content/10.110… 1/
Pinpointing causal variants that disrupt development. So proud of the amazing team on this epic enhancer genotype-to-phenotype study. Well Done, Fabian Lim, @JoeSolvason, Genevieve Ryan, Sophia Le, @granton_jindal, Paige Steffen and Simran Jandu!!! doi.org/10.1038/s41586…
@nicole_delrosso's "Large-scale mapping and mutagenesis of human transcriptional effector domains" now out @Nature! >1,000 effectors and their sequence determinants discovered from screening >2,000 nuclear proteins nature.com/articles/s4158… From @BintuLab in collab w @MCBassik
Honored to receive the VBC PhD Award!
🎉Congratulations to recent graduates @FilipNemcko and @julianehrmann for winning this year’s Vienna BioCenter PhD Award for their outstanding doctoral theses at the @VBCPhdSymposium! More about their projects and all the awardees: imp.ac.at/news/article/v… @viennabiocenter
Our latest research on position-dependent transcriptional regulatory sequences in plants is now published! 🌿 More details in our preprint tweet and in this thread! 👇 nature.com/articles/s4158… 📄🔍 (1/5)
Transcription regulation in plants vs. animals - same-same or different? We show in a new preprint that in plants, regulatory sequences next to the TSS are position-dependent - as opposed to animal enhancers which are position-independent (1/6) biorxiv.org/content/10.110…
ORFtag enables protein functional screens by proteome-wide tagging via randomly integrated cassettes. @FilipNemcko @EllingUlrich @juliusbrennecke @AlexanderStark8 @stark_lab @IMBA_Vienna @IMPvienna @MaxPerutzLabs @viennabiocenter nature.com/articles/s4159…
How do chromatin modifications quantitatively impact gene expression? How do sequence variants or combinatorial marks influence relationships? We developed a modular #EpigenomeEditing toolkit to systematically test these Q, published today 🧵… nature.com/articles/s4158…
🎉Congratulations to @FilipNemcko from @AlexanderStark8's lab for being included in Forbes Slovakia “30 Under 30” list! To earn him the mention is the development of a method that significantly speeds up the understanding of human gene functions. imp.ac.at/news/article/f…
Just earned my PhD! 👨🎓 Huge thanks to all who helped me reach this milestone.
Congratulations to @FilipNemcko PhD (@stark_lab, IMP), who recently defended his thesis: 'Systematic identification and functional characterization of transcriptional regulators' - Well done Filip! 🥂🍾 @univienna @IMPvienna @IMBA_Vienna @gmivienna @MaxPerutzLabs
Our paper on functional discovery of protein degradation and stabilization effectors with proteome-scale induced proximity screens is out in its final version! 1/ nature.com/articles/s4158… rdcu.be/dBUju
How many genes are in the human genome? (The third in an irregular series of threads about #Bioinformatics.) Let’s start by restricting “gene” to mean “protein-coding gene.” For the moment, this number appears to be just under 20,000, far lower than it used to be 1/11
We are very excited to present a major breakthrough achievement – the de novo design of synthetic enhancers for selected tissues in fruit fly embryos in vivo using deep- and transfer learning, @deAlmeida_BPet al published today in @Nature nature.com/articles/s4158…. Thread 👇(1/N)
Interested in systems biology, gene expression, chromatin, genome structure, AI & deep learning? Please join us - @fiddle, @sara_mostafavi, @ABoettiger and all amazing speakers) - on March 13-16 2024 at CSHL (NY, US): meetings.cshl.edu/meetings.aspx?… (please RT)
Happy to share my postdoc work about enhancer-enhancer cooperativity! Find out more at biorxiv.org/content/10.110…
40 years of BIF in numbers. Great celebration near Frankfurt with 170 BIF fellows. The impact of BIF on education and support of young scientists is impressive. 👏 bifonds.de/index.html #education #science is our passion
Interested in epigenetics and the potential function of histone modifications? If so, Hua Wang in our lab has done some beautiful work in defining a role of H3K4me3!! Check out the paper - published today. nature.com/articles/s4158…
whoa, this is bigger than ChatGPT to me. google almost solved music generation, i'd say. google-research.github.io/seanet/musiclm…