Alexander Stark
@AlexanderStark8
Our preprint describing the Range Extender element, which is required and sufficient for long-range enhancer activation at the Shh locus, is out in @Nature. nature.com/articles/s4158…
How do enhancers work over distances that sometimes exceed megabases? Excited to share our work led by @gracecbower where we uncover a unique sequence signature globally associated with long-range enhancer-promoter interactions in developing limb buds: biorxiv.org/content/10.110… 1/
Today marks the end of en-JUNE-eering, the month where I focused mostly on the nitty gritty of improving genomics ML infrastructure. Here are some of the highlights:
Happy to share our recent work, led by @ewholling in which we discovered that poised chromatin sensitizes enhancers to aberrant activation by non-coding mutations, contributing to disease. @UCIBioSci @UCIrvine biorxiv.org/content/10.110…
How do non-coding variants in enhancers cause human disease? Here, in my main PhD work with @evgenykvon, we uncover a surprising mechanism, with generalizable implications for human genomics. tinyurl.com/89tdkevu n/
Calling the lineup 'distinguished' at the 2025 EMBO enhancer mechanics and enhanceropathies workshop at Hindsgavl Castle would be a massive understatement. The lineup is truly royal! @EKFarley #EMBOenhanceropathies @EMBO @AlexanderStark8 @mrmikerobson1
51,3 Millionen Euro für herausragende Grundlagenforschung ⚗️📚 In der ersten Vergaberunde 2025 unterstützt der #FWF 128 Forschungsprojekte. Die Details zu den aktuellen Förderzusagen sind ab sofort online abrufbar. ▶️ fwf.ac.at/aktuelles/deta…
Excited about science and scientific writing? Collaborate with us at the @IMPvienna @viennabiocenter - job opening for a 'Scientific Grant Writer': imp.ac.at/career/open-po… in Vienna, Austria
👩🔬Are you an IMP alumnus? The new Vienna BioCenter Alumni Platform is launching soon. Follow @TrainingVbc for updates and check your inbox!
Calling VBC Alumni, join us today and help build a dynamic, supportive network! Save the date for our online launch - 27 March 2025; more details in your inbox or contact us! alumni.training.vbc.ac.at/people @IMPvienna @IMBA_Vienna @gmivienna @MaxPerutzLabs @univienna @MedUni_Wien
How can #genetics provide insights into disease biology? 📽️ Watch 2024 Birnstiel Award laureate Christina Stankey's great talk to find out: youtube.com/watch?v=IbjyiO… Her research identified ETS2 as a master regulator of macrophage-driven inflammation. @ctstankey
ARGONAUTES 2025 - argonautes.img.cas.cz The grassroot meeting of Argonaute afficionados lives on! The registration for Argonautes 2025 is open. Join us in Prague at @imgprague during 27-30/8, 2025. Check the hashtag #Argonautes2025 here & on bsky for updates.
Congrats to Perutz group leaders Elif Karagöz and @ShotaroOtsuka on becoming tenured professors 🎉 Since 2019, the Karagöz lab has been uncovering how cells maintain protein homeostasis, while the @LabOtsuka explores how the ER and nucleus communicate ➡️ tinyurl.com/2phzhprj
Researchers paid $8.968 billion for their findings to be freely accessible. 🧵1/10
Congratulations to Clemens Plaschka, who was promoted to Senior Group Leader at the IMP. We are thrilled and look forward to Clemens steering his research as part of our community for many more years to come! imp.ac.at/news/article/c…
Ledidi turns any genomics ML model into a controllable sequence designer by inverting the normal ML paradigm. Now, it is significantly faster, flexible, and more powerful than before. Available on GitHub and installable with `pip install ledidi`
"Everything in epigenetics is circular". Here, we explore how memory stored locally on chromatin has a crucial role in stabilising cellular state, updating our view of the epigenetic landscape from one shaped by the genotype, to one moulded by experience doi.org/10.1186/s13059…
CRISPR-StAR enables high-resolution genetic screening in complex in vivo models go.nature.com/4giANvD
Next-level CRISPR screening: New method for identifying cancer’s Achilles’ heels #NBTintheNews via @IMBA_Vienna oeaw.ac.at/imba/research-…
🎉Big news! Our Nucleotide Transformer foundation models for genomics have been published in @naturemethods! The models pave the way for progress in ML and genomics, redefining our approach to genomics prediction tasks and enabling improved performance over specialized methods…
🎉 Big news! Our Nucleotide Transformer foundation models for genomics were just published in @naturemethods! 🚀 So proud of this incredible team @instadeepai! ⭐Paper: go.nature.com/3OA7dWr 📕Research briefing: go.nature.com/3BbSPQY
🆕 publication! 🧬 How do enhancers, located far away in the genome, communicate with their target genes? In @MolecularCell, the lab of @chribue shows how different enhancers cooperate to drive gene expression using a novel synthetic platform ➡️ tinyurl.com/yckubbjb
#Immunotherapy has transformed #cancer treatment, but some cancers evade immune defenses, causing resistance. @obenaufa's lab has discovered how inflammatory monocytes—a type of immune cell—can reactivate cancer-killing T cells within tumors. Read more: imp.ac.at/news/article/a…