Michael Belloy

Extremely excited to finally announce I'm starting my own lab on October 1st at the @Neuro_Genomics center @WUSTL @WUSTLmed @WashUNeurology. Want to study Alzheimer, genetics, GWAS, X chromosome, multi-omics, and sex, APOE4, and ancestry effects? Join me! Ads in the thread.

Past eQTL studies have mostly focused on one gene at a time. But in the human genome, genes often occur in clusters and tend to be co-regulated by shared mechanisms. So why not consider neighboring genes together when mapping eQTLs? A new preprint tests this idea and introduces…

This narrative that the amyloid hypothesis is a hoax based on a disgraced 2006 paper and has distracted us from the "real" cause of AD is everywhere these days. It's cropping up in @nytimes and now from RFK jr. It's fashionable. But it's inaccurate and destructive to the field.

Thrilled to announce that our new @ccrugom lab manuscript detailing the proteogenomic landscape of human cerebrospinal fluid is now live at @NatureGenet. Many thanks to @WUADRC and @WashUNeurology for supporting this work. 1/13 nature.com/articles/s4158…

Want to join the #ADSexGenPIA for the coming 2 years!? It's an amazing opportunity to work with a highly engaged group to make advances in this area. ISTAART members can vote here: alz.surveymonkey.com/r/T8GC8J6

X chromosome dosage compensation through the lens of human genetics! Females have two X chromosomes, but males have one. To compensate for this, one X is randomly inactivated in female cells. Some genes escape from this inactivation. Because both males and females are…

CHOIR is officially published @NatureGenet. No more arbitrary decisions in clustering. Add this to your single-cell toolbox - it will save you so much heart ache. And now it can scale to millions of cells. Compliments of the very talented @cathrine_sant.

"We could all use a little more X!" Thrilled our new study is out. Aging "wakes up" the silent X chromosome in the female brain - and this contributes cognitive resilience. Spearheaded by @MargaretGadek in @ScienceAdvances Collaborators Berenice Benayoun, @BBParis1984…

Ecstatic to see our paper "Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing" now published in @NatureGenet with @towfiqueRaj @panos_roussos @SinaiBrain nature.com/articles/s4158…

The X chromosome inherited from mom impairs cognition and speeds up brain aging. Check out our latest @Nature. @UCSFAging @UCSF nature.com/articles/s4158… nature.com/articles/d4158…

Male-female comparisons are powerful in biomedical research. Unraveling and harnessing mechanistic etiologies of sex differences may reveal new diagnostics and therapeutics for the aging brain. More from us in the latest @NeuroCellPress issue on aging. @BBParis1984 @ctmurphy1…

What better way to start of the new year than registering for the year in review of #ADSexGenPIA. Everything you need to know on sex differences in Alzheimer's disease in 2024, packed in a 1 hour session!

Calling all Sex and Gender Differences in AD PIA members! We need your help for the Year in Review webinar!!! This link is active through next Sunday -- alz.surveymonkey.com/r/SLH6BMW Please share your notable papers on sex/gender differences in AD! #SexGenderAD #Alzheimer'

Excited to share our work, new in @ScienceMagazine: science.org/doi/10.1126/sc…. We explored how sex chromosomes, gonadal hormones, and their interaction shape cellular responses in aging and #Alzheimers mouse models. This led to key insights on Tlr7 and neurodegeneration 🧵(1/5)

Amazing work by @laura_actg and her lab identifying non-proteomics biomarkers, specifically circular RNAs for #Parkinsons, with AUC>0.95!! Impressive. Very pioneering work with important implications @WashUNeurology. Supported by @MichaelJFoxOrg nature.com/articles/s4153…

Double Nature Genetics publications requires some 😎😎😎😎. Very cool and showing the great working ongoing at the @Neuro_Genomics center!

Integration of CSF proteomics, metabolomics and genetics identify causal and druggable targets for #Alzheimers disease The Cruchaga lab published two side-to-side manuscripts in Nature genetics (nature.com/articles/s4158…; nature.com/articles/s4158…). @WUADRC @WashUNeurology

Make sure to join us for AAIC advancement: APOE & Lipid Biology. There's going to be some great new insights into everything APOE! Abstract submission deadline is Dec 2. alz.org/apoe/overview.…

Dementia prevention in Africa, a region with many modifiable risk factors, is critically needed. Our multinational Africa-FINGERS, led by the dynamo @MomohChi & colls, offers innovative multidomain interventions tailored to the region's unique challenges➡doi.org/10.1002/alz.14……

We identified Widespread transposable element dysregulation in human aging brains with Alzheimer’s disease and validated it by CRISPR from @YinShenLab Thanks @NIHAging @CCLRI @YinShenLab alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…

Great overview by @alzforum on our recent Alzheimer's disease X chromosome wide association study, as well as 2 other similar studies that just came out. Very exciting to see all these new insights on the X! alzforum.org/news/research-…. jamanetwork.com/journals/jaman…