Gan Lab

And that concludes our chronicles on X! Please follow us on Bluesky🦋: liganlab.bsky.social

Big congratulations to Dr. @CelesteParraB! On Tues., Dr. Parra Bravo defended her thesis with command and grace. Next, she’s headed to a postdoc in the Rosato lab at Dartmouth. We’re so proud of all she’s accomplished and can’t wait to see her continued contributions to science!

Parental origin of transgene modulates amyloid-β plaque burden in the 5xFAD mouse model of Alzheimer’s disease: @NeuroCellPress cell.com/neuron/fulltex…

Congratulations, Dr. Huang!! Gloria defended her thesis today with flying colors. We're so proud of the fantastic science you've done in the past 5.5 years and the energy you brought t lab ❤️🎉

Elated to share my PhD work, new in @ScienceMagazine science.org/doi/10.1126/sc…👩🏻‍🔬 I was struck by how little we knew about the role of biological sex in the brain, especially in response to sex-biased diseases. In #Alzheimers (AD), 60% of patients are women 🧵

Inhibiting an immune signaling protein called TLR7 may help preserve the protective layer surrounding nerve fibers in the brain during both Alzheimer’s disease and ordinary aging, according to preclinical study led by Dr. Li Gan (@LiGanLab). Full story: bit.ly/49bdjFS

Tlr7 drives sex differences in age- and Alzheimer’s disease–related demyelination | @ScienceMagazine science.org/doi/10.1126/sc…

New finding on APOE today in @CellCellPress: APOE2 and the Christchurch mutation are defective in LDLR binding. Decreased lipidated ApoE-receptor interactions may protect against the pathogenicity of ApoE and its lipid cargoes in lysosomes cell.com/cell/fulltext/…

Thrilled to share new work from our lab led by ⁦@mitchkim_mw⁩! The results provide new insight to immune privilege and hopefully diagnostic/therapeutic tools || Endogenous self-peptides guard immune privilege of the central nervous system | Nature nature.com/articles/s4158…

Mitochondrial fatty acid oxidation drives senescence; science.org/doi/10.1126/sc…

Where to start? Activity-dependent alternative translation initiation generates multifunctional proteoforms in the brain dlvr.it/TFZJqZ

Molecular mechanisms of mitochondrial dynamics we aim to present a valuable framework reflecting current perspectives on how mitochondrial membrane remodelling is regulated. nature.com/articles/s4158…

Our goal for the #TauConsortium is to foster collaboration between scientists to help research primary tauopathies. An example of this collaboration in action is the Consortium members’ contribution to a PET radiotracer trial in healthy adult patients: nature.com/articles/s4146…

Could harnessing the brain’s intrinsic cognitive #Resilience mechanisms lead to treatments before onset of #AlzheimersDisease / #Dementia? Learn More on Oct 25 as you JOIN #MSNseminars & hosts @fkchiang89 & @nicole_bussola when they welcome @WeillCornell’s @SadafAmin24.

Modeling Parkinson’s disease pathology in human dopaminergic neurons by sequential exposure to α-synuclein fibrils and proinflammatory cytokines @NatureNeuro nature.com/articles/s4159…