Dena Dubal
@DenaDubal
Neuroscientist, Neurologist, and Aging Researcher at UCSF
The X chromosome inherited from mom impairs cognition and speeds up brain aging. Check out our latest @Nature. @UCSFAging @UCSF nature.com/articles/s4158… nature.com/articles/d4158…
A ‘silent X’ chromosome in older female mice may help answer an age-old question—how do most women outlive men & retain cognitive abilities longer? The silent X "reawakens late in life, probably helping to slow cognitive decline,” Dr. @DenaDubal explains. ucsfh.org/4ivp2m6
In a remarkable study of congenital deafness in children, Gene Therapy was a blockbluster treatment (even better than Cochlear Implantation) jamanetwork.com/journals/jaman… @JAMANeuro
Step Aside Longevity Bros. It’s Time for the Longevity Ladies. - @WSJ . Terrific chatting with @AmyDMarcus about our X chromosome work! wsj.com/health/wellnes…
I'm thrilled to share our new study out in @NatureMedicine! We show that a blood test can estimate how aged or youthful one’s organs are and that these organ ages predict future disease and lifespan. Final paper from my PhD in the @wysscoray lab. 🧵1/12 🔗 nature.com/articles/s4159…
Super amazing group and amazing mentors. Highly recommend!
🚨 We're hiring! 🚨 The @ucsfmac is recruiting a postdoc focused on biofluid proteomics in neurodegenerative disease. Co-mentored by me + @kbcasaletto. Please share or reach out! 🧠🧪 Apply here: healthyaging.ucsf.edu/news/postdocto… #neurodegeneration #proteomics #bioinformatics #postdoc
Samira is off to start her own lab at @TempleUniv - we celebrated her tonight with stories, chocolate, and tacos! I’m very proud of her - and her paradigm-shifting discoveries on aging and the X chromosome. @SimonsFdn @UCSF
🚨Very excited to share a new paper from our lab in Neuron (@NeuroCellPress), on the influence of the estrous cycle on structural and functional plasticity in the hippocampus: sciencedirect.com/science/articl… Thread below:
With gratitude for the Pignolo Prize in Aging Research from @upenn. Thanks David Wok, Edward Lee, John Pignolo, Virginia Lee - and others. Wonderful occasion!
From geroscience to precision geromedicine: Understanding and managing aging. A comprehensive review published in @CellCellPress with many incredible colleagues☺️ cell.com/callback?red_u…
"We have far to go and more to do" - thanks Katherine Bourzac @nature for including me in this thoughtful piece. Honored to contribute to the conversation among brilliant voices on Why women experience Alzheimer’s disease differently from men nature.com/articles/d4158…
Congrats Margaret @margaretgadek on a wildly successful PhD! Onto the MD! @UCSF @SimonsFdn
In people with diabetes, GLP-1 and SGLT2i drugs were associated with less Alzheimer's disease and related dementias jamanetwork.com/journals/jaman…
“Do things that are big and important - not incremental or mediocre. They take the same amount of time.” Stephen Hauser as we cared for patients ‘07 @UCSFMedicine
The 2025 Breakthrough Prize in Life Sciences goes to Alberto Ascherio, who showed the key risk factor for multiple sclerosis is infection with the Epstein-Barr virus; and to Stephen Hauser, who discovered central mechanisms of the disease and developed life-changing treatments…
Today I became a cool Auntie. My 12yo nephew reads the @nytimes (what?!) and stumbled upon our discovery.
The 2025 Breakthrough Prize in Life Sciences goes to Alberto Ascherio, who showed the key risk factor for multiple sclerosis is infection with the Epstein-Barr virus; and to Stephen Hauser, who discovered central mechanisms of the disease and developed life-changing treatments…
Women tend to live longer than men and are often more resilient to cognitive decline as they age. Now researchers might have uncovered a source for this resilience: the second X chromosome in female cells go.nature.com/41K8Ubc
"A little boost went a long way" - increasing an X factor from the silent X chromosome improved cognition in aging male and female mice. What a privilege to have our discovery reported by @ginakolata in @nytimes, alongside amazing studies on women's health from Kaitlin Casaletto…
Thanks to @NIH for highlighting our work on how Mom’s X chromosome accelerates brain aging and impairs cognition. nia.nih.gov/news/mothers-x…
“It’s a paradigm shift to know that the silent X doesn’t stay asleep,” says Dena Dubal, a neuroscientist and neurologist at the University of California School of Medicine in San Francisco, who led the study. go.nature.com/4hWBYlj
"We could all use a little more X!" Thrilled our new study is out. Aging "wakes up" the silent X chromosome in the female brain - and this contributes cognitive resilience. Spearheaded by @MargaretGadek in @ScienceAdvances Collaborators Berenice Benayoun, @BBParis1984…