Feixiong Cheng
@FeixiongCheng
Director, Cleveland Clinic Genome Center. Utilize genomic science and systems biology to predict drug targets and identify mechanisms for Alzheimer’s disease.
Join us at the 2025 Alzheimer's Association International Conference! I will be discussing ADRD funding opportunities during the ISTAART Intermission on Sunday.
The Alzheimer’s drug pipeline is more robust than ever, moving beyond amyloid, with 138 novel drugs in 182 clinical trials targeting new biology of aging pathways, including inflammation, tau proteins, vascular health and more. @Medscape @DrJeffCummings wb.md/4lJh62p
14 M brain cells, 31 regions, 2,239 brains → one Human Brain Atlas🧠 Mito‑charged 🏭 SST neurons + sex‑tuned microglia appear to guard cognition even amid amyloid & tau scVI / scANVI handled batch correction, latent embedding and semi‑supervised cell‑type annotation across…
I spoke with an NIH program officer yesterday who said that, given the massive 44% cut planned for NIH, they were only planning to award about 12 new grants before the end of the year, which are mainly ones in the 1st and 2nd percentile, so the 3 grants we had with good scores…
The NIH has decided that scientists can only submit 6 grants a year. OK. But you need a score that’s < 10% at least to get funded. Meaning, at best, 1 out of 10 grants you submit will have a chance (YMMV of course). 🫠
State of Ohio awards Miami University $7 million to create quantum computing workforce in Ohio: University partnering with Cleveland Clinic to launch Ohio Institute for Quantum Computing miamioh.edu/news/2025/07/s… @miamiuniversity @OhioHigherEd @CleClinicNews
Researchers at @McMasterU, @ClevelandClinic & Case Comprehensive Cancer Center (@caseccc) have uncovered how a protein long associated with Alzheimer’s disease helps lung cancer spread to the brain - a discovery that provides hope for potential treatment. ow.ly/P3i250Wl2IJ
🔥 Literally hot off the press 🔥 Such an honor to have proposed this textbook & serve as Editor! What a pleasure working with @ElsevierConnect @Scopus @sciencedirect and so many incredible #CardioOnc authors, who are colleagues, mentees, friends, leaders, sponsors & mentors 🤩
We are expanding Avon Hospital and the Richard E. Jacobs Family Health Center to meet the growing demand for care on Cleveland's west side. The project will nearly double the size of our campus in Avon. Learn more: cle.clinic/44mr1nC
I am excited to share new plans for a significant expansion of @ClevelandClinic's Avon campus. This is an example of our commitment to reinvesting in our mission to serve more patients and meet the unique needs of our communities. Read More: bit.ly/45Gjp1t
Fantastic AI/ML session is happening now at the AD Golden Conference presenting by @doctorcorces @david_a_knowles Dr. Steven Finkbeiner and other fabulous speakers. Thanks @towfiqueRaj and Dr. Olivier Lichtarge for this well-organized Golden conference!!
The first Alzheimer’s Disease Golden Conference is happening now!! It is exciting to present our AD research in Wednesday and many networking and discussions with all amazing collaborators!!! grc.org/alzheimer-s-di… Thanks our co-chairs @towfiqueRaj Oliver Lichtarge @NIHAging
AI is mining big data to repurpose drugs. Early wins in blood disorders, and now hypothesis-generating candidates are emerging for Parkinson’s & Alzheimer’s. @FeixiongCheng @AANMember #NeuroTwitter hubs.la/Q03sT5zX0
Article covering a few key examples of how NIH funding cuts are affecting research on #Alzheimers disease: The social cost of federal cuts to Alzheimer’s research universityworldnews.com/post.php?story…
‼️Anyone interested in organ fibrosis please join us for the Keystone Fibrosis Symposium 2026 ‘Cross Organ Pathology and Pathways to Clinical Development’ ‼️Introduction video can be found here url.avanan.click/v2/r01/___http…. Registration 👉🏻 keysym.us/KSFibrosis26 @Suzanne_Devkota
What if the next Alzheimer's breakthrough isn't a new drug - but an old one? @NatureComms reveals AI/ big data are uncovering surprising treatments for AD. - Diabetes drugs - Asthma meds - Even Viagra Here's what they're uncovering and why you aren't hearing about this 🧵
138 drugs in the Alzheimer's pipeline 📈 - 9% growth from last year - 74% target the disease itself (not just symptoms) - 182 trials actively recruiting worldwide Key shift: We're moving BEYOND amyloid to 15 different disease targets. This is what progress looks like.
🧬AlphaFold3 nails protein structure prediction ... except for 48% of the interactome 😅 PIONEER2.0 blends homology + DL to map interfaces for 352k human PPIs, beating AF3 where it falters.
🎧 New AD/PD™ Session Spotlight out now! In this episode, @DrJeffCummings breaks down the current state of the #Alzheimers disease drug development pipeline - from biomarker breakthroughs to emerging therapeutic targets and global trial trends. If you're involved in drug…
Cures Within Reach @CuresWReach is now accepting submissions for Phase I or Phase IIA clinical trials to validate AI-driven drug repurposing opportunities in any unsolved disease! @ChanZuckerberg Eligible clinical trials must include AI-generated data as part of the preclinical…
Our new #ClinicalTrial funding RFP for trials in any disease based anywhere in the world to validate #AI-driven drug #repurposing is open until Aug 25! Info at bit.ly/cwrrfps. Thanks to our lead partner @ChanZuckerberg Help spread the word! #ClinicalTrials #RareDiseases