Aydogan Lab
@AydoganLab
We study principles of biological time control with a focus on the emerging concept of autonomous clocks. Dept. of Genetics & Development, Columbia University
EXCITED to unroll this 🧵 on our new story on the metabolic licensing of animal development... How did we even get here..? shorturl.at/vuCIh Early embryo is thought of a pre-set machine that's set to go once it's fertilized - check out this gorgeous 📽️from Phil Keller!
Hello everyone! I am helping to organize a one-day symposium on fluorescent metabolite biosensors and their use in metabolism research. It will be May 12-13 and associated with the Cold Spring Harbor Laboratory “Mechanisms of Metabolic Signaling” Symposium. Our field needs to be…
Join the #VosshallLab as a postdoctoral scientist! Fully funded position in New York City @RockefellerUniv hhmi.wd1.myworkdayjobs.com/en-US/External…
I’m happy to share that my latest PhD work is published in @embojournal! We demonstrate a fundamental role for Annexin A5 in regulating mitochondrial calcium signaling and apoptosis. embopress.org/doi/full/10.10…
🚨New paper alert!🚨 Our latest work uncovers how cells detect and destroy defective ribosomes before they cause harm. A key quality control pathway with implications for development and disease. #ribosome #qualitycontrol Check it out in Molecular Cell: authors.elsevier.com/a/1l2MA3vVUPVa…
This is the most important paper in the circadian field in over a decade. A completely new clock component that is evolutionarily conserved. @Eric_E_Zhang @susanksgolden @ @SRBR_Outreach rdcu.be/efxV8
Our review on genetically encoded CDK biosensors is finally out in CSF! Take a look! jstage.jst.go.jp/article/csf/ad…
【早期公開】@goto_yuhei さんによる総説です！J-STAGE Articles - Capturing CDKs in Action: Live-Cell Biosensors Pioneer the New Frontiers in Cell Cycle Research doi.org/10.1247/csf.25…
Excited to share this review on chromatin-metabolism crosstalk, lead by our star student Varun Sahu. Here, Varun summarizes the molecular principles governing metabolite-chromatin interaction & highlights emerging technologies that could advance the field. There’re lots to learn!
In this review for our focus issue on patterns in molecular biology, @LuLaboratory explores how metabolites and metabolic enzymes regulate chromatin and histone modification patterns, highlighting the crosstalk between the metabolome and the epigenome. cell.com/molecular-cell…
We exposed yeast to -196 C freeze-thaw (without cryoprotectants) and interesting things happened -- the survival went up from about 1% to close to 80% in just 25 cycles! The preprint is out and feedback is highly welcome -- biorxiv.org/content/10.110…
Very important study & call for higher standards shorturl.at/lUbzF It'ld be good to hear @cziscience and @Nature say about this, which could be deemed #DataPolution. To think that some people want to use AI on this data to understand the cell! How can we sort this out?
If you like Wallace's tweetorial and are going to ASCB, look out for my talk Tues. Dec 17th on how the microtubule cytoskeleton dictates RNA regionalization in Stentor! #cellbio2024 #stentor #protist #NIHMOSAIC
Where does pattern come from inside cells? in this revised preprint, @aralbright93 shows that regionalization of mRNA in a Stentor cell depends on dynein motors and the microtubule cytoskeleton doi.org/10.1101/2023.0…
The final open-access version of our @AnnualReviews on the ubiquity of polyploidy and its common rules is now available! So fun to work with colleagues from the plant @soltislab and cancer @TimourBaslan @johnpmorrisiv fields! annualreviews.org/content/journa…
How do organelles fit together inside a crowded cell? Answering this question requires a way to image many organelles in a whole cell at high resolution with high throughput. Our new preprint shows how to do this in yeast using soft x-ray tomography biorxiv.org/content/10.110…
Our perspective on Hsp90 as a global modifier of the genotype-phenotype-fitness map, along with its implications for evolution in nature and clinical settings, is now out in JMB. We review the existing literature, identify open questions, contextualize our recent findings on…
I am excited to announce that our latest work is now published @JCellBiol! Huge congratulations to the co-authors @MaryHuda97 @KoyuncuMukadder @cansudilege. Big thanks to our funding bodies @Tubitak and @EMBO_YIP, @KocSciences, and to many labs who shared plasmid/strains with us.
@MaryHuda97 et al. @CaydasiLab @Kocuniversity reveal the dynamics of the vacuolar signaling lipid PI(3,5)P2 in budding yeast. PI(3,5)P2 synthesis is asymmetric during #mitosis and plays a key role in establishing vacuolar pH asymmetry. hubs.la/Q02Xx8N00 #Lipids
Excited to share our new paper led by @mattabolite in collaboration with Saharon Rosset showing that the Warburg Effect is the result of faster ATP production by glycolysis than respiration. A 🧵... 1/n pnas.org/doi/10.1073/pn…
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Can we make Acoustic Proteins with different "colors" the way the developers of GFP made BFP, YFP, etc?🌈 Yes, via #directedevolution of #gasvesicles! Congrats to @nivinnystrom et al on the first GVs multiplexed based on nonlinear response to ultrasound. biorxiv.org/content/10.110…
Good time to read our Tweetorial/ X-planation of our nature.com/articles/s4158… paper now featured on the cover of @Nature!
🚀Big News! Excited to share our work “The Interplay of Mutagenesis and ecDNA Shapes Urothelial Cancer Evolution” published in @Nature! nature.com/articles/s4158…
Thank you @NatureRevCancer for highlighting our recent work on chromothripsis! Here’s a link to the paper: cell.com/cell/fulltext/…
NEW content online! Fanconi anaemia pathway induces chromosome shattering go.nature.com/4ehX6j9
Massive congrats to our friend and colleague @dudin_o for their story on what I think will be a landmark study for understanding the evolution of embryogenesis!!!
Our latest #Ichthyosporean #EvoDevo story, led by M. Olivetta @ChandniBhickta @NChiaruttini & in co. with @burnsajohn is finally out @Nature . Link⏩: nature.com/articles/s4158… Preprint⏩: biorxiv.org/content/10.110… 1/5)
.@VerhoefJulie, @TacoKooij et al @radboudumc combine 3D fluorescent microscopy & FIB-SEM to capture P. falciparum mitochondrial & apicoplast division in unprecedented detail, proposing a new mechanistic model for organelle division & segregation. hubs.ly/Q02WCS7t0 #malaria