Nature Reviews Cancer
@NatureRevCancer
Nature Reviews Cancer is a monthly review journal for researchers working on cancer. We, the editors, highlight the most exciting topics in cancer research.
Our July issue is LIVE! 🌞🥵🏖️ It features articles on: - Targeted protein degradation for cancer therapy - Advances in therapeutic cancer vaccines - The TGFβ paradox in HPV-driven cancer - The paths to metastasis Happy reading! 👇 📖 bit.ly/3I1QUla
NEW content online! Metabolic adaptations of brain metastasis bit.ly/44KqhtS
In this #ToolsoftheTrade article, Jess Hebert describes the development and use of Cas12a mice for the unbiased, high-throughput generation and interrogation of complex tumour genotypes. 🐭🧫🥽 bit.ly/4kYPfKX
NEW content online! Replication timings affect the frequency of chromosomal translocation bit.ly/4mcaPfT
In this Comment, Grünwald & Khokha call for a shift in comprehension of tumour tissue organization; while tumour tissues are heterogeneous, they are not disordered, & instead, propagate their functions via a considerable level of self-organization. 📖 👇 bit.ly/46nkL1r
NEW content online! Environmental endocrine disruptors: rethinking the origins of early-onset ER+ breast cancer bit.ly/3TS9gaR
People in the USA who are incarcerated, or have a history of incarceration, face worse access to cancer care, leading to poorer outcomes. Zhao & colleagues highlight the need to address these inequities through coordinated action. bit.ly/4ma8UZn
#Perspective 🚨 Lazure and Gomes @lab_gomes argue that metabolic changes that occur as a result of #ageing may shape tumour initiation and progression and the development of metastatic disease. ⬇️ 📖 bit.ly/3IC1oYE @MoffittResearch
NEW content online! Cas12a mice enable the rapid generation of highly complex tumour genotypes bit.ly/45bsVcc
#Review 🚨 Henry & DeGregori discuss models and methods used to study the connection between ageing and cancer, advocating advocating for the wider adoption of age-appropriate models of cancer to improve clinical translation 📖⬇️ bit.ly/4eQqoaw @CUSystem
#Comment 🚨 Asghar&Chung highlight cancer applications of digital twins, integrating molecular data & drug responses to inform personalized treatment & accelerate drug development through clinical trial simulation 📖⬇️ bit.ly/40X6kxo @royalmarsdenNHS @MDAndersonNews
#ResearchHighlight 🚨 A new study by Tang et al. reveals that tryptophan metabolism plays a crucial role in the maturation of tertiary lymphoid structures (TLSs), which can impact their immunological function and immunotherapy response. 📖 ⬇️ bit.ly/4nPQgaI
NEW content online! Tumour tissue: heterogeneous, but not disordered bit.ly/40NwzGC
NEW content online! Cancer progression through the lens of age-induced metabolic reprogramming bit.ly/3IkNY31
NEW content online! Deviant by environment bit.ly/40aug0b
NEW content online! Modelling the ageing dependence of cancer evolutionary trajectories bit.ly/3GswOA7
NEW content online! Application of digital twins for personalized oncology bit.ly/3GeKsH2
In this #ToolsoftheTrade article, Yahaya A. Yabo describes the development of a neuropathology spatial transcriptomic analysis (NePSTA), an AI-based tool to identify and map unique spatial patterns within tissues. Read it here👇 bit.ly/45W0TCr
#ResearchHighlight 🚨 While the role of disulfide stress in cancer is known, its impact on anti-tumour immunity was unclear. Now, disulfide stress is shown to induce disulfidptosis in intratumoural CD8+ T cells, promoting T cell exhaustion. 👇 bit.ly/4lqXkc4
NEW content online! Combining spatial transcriptomics and AI to enhance brain tumour diagnosis bit.ly/4evZjt3
Perspective 🚨 Orsolya Vincze @OVincze, Thomas Pradeu &Co discuss how cancer research can be advanced using comparative oncology and call for the increased use of non-conventional model organisms to advance cancer prevention and treatment. 📖 ⬇️ bit.ly/3U0oIBD
