Aaron Novikoff
@AaronNovikoff
The rich man's wealth is his strong city
Amgen's new GLP-1R agonist/GIPR antagonist, AMG 133, is making waves in the anti-obesity field. Curious? Our latest short piece highlights the first clinical success of AMG 133, its background, and the GIPR-centric questions that arise from its success. sciencedirect.com/science/articl…
For those interested: We have a spot for a new PhD student to work with me on GPCR/RTK dynamics. If you're interested in cutting-edge analysis of anti-obesity pharmacology, and the development of potentially new pharma strategies, check it out! uni-tuebingen.de/universitaet/k…
Signaling by intracellular β2-adrenergic receptors regulates AMPA receptor trafficking and synaptic plasticity: Cell Reports cell.com/cell-reports/f…
Amazed to share our new study published in @CellCellPress revealing how the liver contributes to weight loss in cancer via disruption of a circadian regulator and secretion of catabolic factors. Big thanks to @FiskerSchmidt, S. Herzig, @BerrielDiaz 🧵👇 cell.com/cell/fulltext/…
In 2007, physicist Freeman Dyson wrote an essay called “Our Biotech Future” for The New York Review. In it, he wrote: “I see a bright future for the biotechnology industry when it follows the path of the computer industry…becoming small and domesticated rather than big and…
I am excited to share our latest work in @Neuron exploring the pharmacology of psychedelics. I am deeply grateful to my PI, Prof. Bryan Roth, @zenbrainest, for his exceptional guidance, and to all my co-authors for their valuable collaborations.
New! Online now: Localized GLP1 receptor pre-internalization directs pancreatic alpha cell to beta cell communication dlvr.it/TLvwgF
CagriSema drives weight loss in rats by reducing energy intake and preserving energy expenditure go.nature.com/3GBgqNF
Studies in rats reveal one-third of CagriSema’s #weightloss efficacy arises from an effect on energy expenditure, the blunting of metabolic adaptation, which contributes to the successful treatment of #obesity nature.com/articles/s4225… @NatMetabolism
You can’t beat The Sandlot’s 4th of July scene. Happy 4th, everyone! 🇺🇸
THE GREATEST TO EVER DO IT 17 NATHAN’S HOT DOG TITLES FOR JOEY CHESTNUT
Semaglutide effects on energy balance are mediated by Adcyap1+ neurons in the dorsal vagal complex dlvr.it/TLjyJ7
The champ is back!!! 👑
Joey Chestnut vows to reclaim Nathan’s Hot Dog Eating Contest crown after being barred last year trib.al/LEwkHdU
Studies in mice reveal that LEAP2 analogs have the potential to enhance the efficacy of glucagon-like peptide 1 receptor agonism and support durable #weightloss diabetesjournals.org/diabetes/artic…
Innovation in the #weightloss space continues with an emerging Triple G oral peptide #obesity to enter into clinical development for obesity in 2026. biospace.com/drug-developme…
Triglycerides are an important fuel reserve for synapse function in the brain go.nature.com/4nvjk7k
Clearing Brain Sugar Stores Could Protect Against Dementia New research has revealed that glycogen metabolism in neurons plays a surprising role in defending the brain against neurodegenerative diseases like Alzheimer’s. Long assumed to be insignificant in neurons, glycogen…
A new preprint dives into the ever-fascinating noncoding universe, offering fresh insights that reshape our understanding of gene regulation. In the classical view, an enhancer's tissue-specificity is seen as black and white: active in one tissue and inactive in the others. In…
Biased adrenergic agonists – a novel treatment for diabetes! Amazing paper in Cell from a project led by @ProfBengtsson (Stockholm Uni) and Shane Wright (Karolinska Inst): cell.com/cell/fulltext/… Great work by my student Nour Kahlous, who performed simulations of the compounds.
More preclinical data extending the anti-aversive actions of GIP through studies of Tirzepatide science.org/doi/10.1126/sc… @ScienceAdvances