Stetson
@stetson_thacker
Human genetics. Precision Oncology. Books. Anything that piques my curiosity. Opinions are my own.
It’s because the classes are harder! You *could* make really hard humanities classes to weed out the weakest students, but schools in practice don’t do that so it actually is the case that science majors are smarter and harder working.
i hate the fact that math and science smart students are considered smarter than english and history smart students
Creative use of UK Biobank WGS data: fishing out non-human DNA reads from WGS data to measure latent Epstein-Barr viral infection. The plot below shows phenome-wide associations of "EBV DNAemia" in half a million individuals. Nyeo et al. bioRxiv 2025 biorxiv.org/content/10.110…
Genomic prediction's future will likely be brighter than its present:
Given two genomes, can you tell who’s taller or more prone to a disease? How confident can you be? A fresh take on phenotypic inference, now out in @NatureComms : rdcu.be/exW4f See thread🧵👇:
Very happy to share our new paper now on @medrxivpreprint: “Genetic risk effects act in sets”, a great effort led my PhD student @JolienRietkerk, and performed together with collaborators @andywdahl, @AndrewSchork, @jonathan_flint1 etc. Thread 1/n
"Especially in high-income countries, the birth rate has very quickly plummeted in a sustained way...Older people, those age 65 or above, now outnumber children in 11 states. That has risen sharply from just three states five years ago." npr.org/2025/07/07/nx-…
Our latest paper (since last week), Long read WGS boosts detection of causal variants. But long reads are a game changer WRT to resolving complex genetic variation and its functional consequences and regulatory effects. medrxiv.org/content/10.110…
Go west, young Siberian razibkhan.com/p/go-west-youn… A 1999 paper in Nature identified a mutation on the human Y chromosome with a geographic distribution that, depending on where you stood, was either peculiar or deeply validating. The mutation was later found to be part of the N1c…
Our focus on nonsynonymous variation detected by short-read sequencing technologies often narrows our total understanding of genetic variation.
There are much more structural variants within our genomes than previously conceived, >26,000 per person nature.com/articles/s4158… nature.com/articles/s4158…
From "After the Spike": "The year 2012 may well turn out to be the year in which the most humans were ever born—ever as in ever for as long as humanity exists." Going to live-tweet interesting bits.
The Buckingham Manifesto for a Post-Progressive Social Science was just published in The Chronicle of Higher Ed. I am one of the signers, and encourage other academics and students to sign on. docs.google.com/forms/d/e/1FAI…
GLP-1 drugs appear to have also destroyed the "healthy at any size" claims that used to be in circulation...
New newsletter: We need to talk about how GLP-1 drugs seem to be good for practically everything—and what that means for the future of medicine and health Hundreds of studies have now shown that GLP-1s, such as Ozempic and Zepbound: - seem to curb alcohol, cocaine, and tobacco…
New PNAS paper on US academics' publication rates during tenure-track and post-tenure. Publication rates rise steeply until tenure and then plateau for lab-based fields, while declining for other fields.
An antigen-presenting cell subtype tames the immune response to food antigens in early life. Learn more in a new #SciencePerspective: scim.ag/3IyZY0Y
Really wild how there are two housing markets now. If you live in the northeast or Midwest, prices are rising, everywhere around you. If you live in the south or west, prices are falling, everywhere around you. And if you live in Florida, the bottom’s falling out.
I can’t get this line out of my head since reading it at the end of the abstract for this paper: “Sleep, like aging, may be an inescapable consequence of aerobic metabolism.” nature.com/articles/s4158…
In fact, young men with a college degree now have the same unemployment rate as young men who didn’t go to college, completely erasing the graduate employment premium. Whereas a healthy premium remains for young women.
The HLA region is key to human health, but is often excluded in large-scale GWAS. Informing future studies on its influence, @AJHGNews' latest article reports HLA haplotype-based associations across thousands of diseases: bit.ly/4lrJiXT #ASHG @jkpritch
Eight healthy babies born after IVF using mitochondrial DNA from third person #mitochondrialdonation nejm.org/doi/full/10.10…
From early days of autism genetics PMID: 24768552, we marveled at the "functional convergence". The genes that were identified by CNV, whole exome studies were clearly pointing at pathways that regulate early brain development! including synaptic, chromatin, cell signaling 2/N
On behalf of the CNV analysis workgroup of the @PGCgenetics I'm pleased to share our latest paper "Psychiatric disorders converge on common pathways but diverge in cellular context, spatial distribution, and directionality of genetic effects" 🧵1/N medrxiv.org/content/10.110…