Reuben Philip
@reuben_phi
PhD Candidate @PelletierLab, @SinaiHealth, @UofT 🍁 Advanced Imaging 🔬 | Genome Engineering ✂️ I like to light cells up and watch em dance
Previous submissions to @NikonSmallWorld. Dividing with too many centrosomes! #FluorescenceFriday #Centrosome
Five years of work, one big question: Which has a greater impact on aging—our environment or our genes? I'm excited to share our paper published today in Nature Medicine, demonstrating the major role of the #exposome in shaping mortality and #aging. nature.com/articles/s4159…
My lab’s 5-year NIH R01 grant, awarded to study gene therapy for hearing loss, was abruptly terminated. I want to share how this action has been incredibly harmful and disruptive, not just to my lab, but to the scientific process itself. 1/15
In a medical milestone, a customized base editor was developed, characterized in human and mouse cells, tested in mice, studied for safety in non-human primates, cleared by @US_FDA for clinical trial use, manufactured as a complex with an LNP, and dosed into a baby with a severe,…
63 biliary cancer cell lines!! An unbelievable resource from the Bardeesy Lab @MGHCancerCenter
Now online in @CD_AACR: Generation of a Biliary Tract Cancer Cell Line Atlas Identifies Molecular Subtypes and Therapeutic Targets - by @Vindhya_Vijay, Negin Karisani,@getz_lab, Nabeel Bardeesy, and colleagues doi.org/10.1158/2159-8… @MGHCancerCenter @broadinstitute
Excited to share our pre-print on the molecular architecture of heterochromatin in human cells🧬🔬 w/ @jpkreysing, Johannes Betz,Turoňová lab, @MarinaLusic, Hummer lab, @Beck_Laboratory, @MPIbp 🔗 Preprint here: doi.org/10.1101/2025.0…
Today we report in @NatureMedicine the development of a base editing strategy for prion disease, currently a fatal and rapidly progressing neurogenerative condition with no effective treatment. @PrionAlliance @DevermanLab (1/13) drive.google.com/file/d/1DVpKrz…
Ready for the most powerful foundation model for medical images/videos? 🚨 Just dropped: MedSAM2 The next-gen foundation model for 3D medical image & video segmentation — built on top of SAM 2.1. • Project site: medsam2.github.io • Paper: arxiv.org/abs/2504.03600 Why…
Of >105,000 participants with 30-year follow-up, only 9.3% achieved healthy aging (age 70, w/o any chronic diseases). Their diet was significantly associated with this outcome🧵 @NatureMedicine
Our live imaging video of muscle cell fusion is hosted on HHMI's Beautiful Biology! Thanks BB for selecting our video and congratulations to @YueluUTSW! hhmi.org/beautifulbiolo…
Do you LOVE organelles?? Well I am THRILLED to announce that Nellie has been published in @naturemethods! Nellie a fully automated pipeline for organelle segmentation, tracking, and hierarchical feature extraction in 2D, 3D, timelapse, multichannel live-cell microscopy 🧵1/N
Two absolutely fantastic bioimage analysis papers out today offering exceptional, generalizable tools for segmentation--Cellpose3 and Segment Anything for Microscopy. (1/3)
New paper from the lab🎈. Introducing Micro Immune Response On-chip (MIRO), a device that replicates tumors and their microenvironment to better understand responses to immunotherapies (cyan=immune cells, red=cancer, green=CAFs). @IBECBarcelona
That’s my Canada. Peaceful, trustworthy, supportive, world-class excellence. I stand on guard for thee.
📢Excited to introduce NanoCas -our new mini CRISPR system that can reach tissues previously out of reach! By shrinking CRISPR to 1/3 its normal size, we can now edit genes in muscle, heart & brain that were difficult to access before. Summary & link to paper:
Explore our tagging tools from the @Pelletierlab! They feature cassettes with mStayGold for bright and photostable endogenous fusions. Now available on @Addgene: addgene.org/Laurence_Pelle…. Check out the paper in @embojournal: embopress.org/doi/full/10.10… #FluorescenceFriday
Did you know that Sinai Health’s Network Biology Collaborative Centre has the latest microscopy instruments, software & state-of-the-art expertise available to researchers from any institution? Find out how you too can advance your research 👉 bit.ly/4fzgXM9
My Tidyverse local synteny visualizer is up on GitHub: github.com/cxli233/TidyLo… GitHub page contains 2 example datasets, as well as step-by-step instruction & explanations on how it works. Details on required input data are discussed in the GitHub page.
#qTAG: Laurence Pelletier @laurpelletier and coworkers present an adaptable set of optimized #CRISPR repair cassettes for streamlined endogenous tagging, enabling diverse applications in functional protein studies within their native regulatory context embopress.org/doi/full/10.10…
Single-cell genomics breaks new ground in cell cycle detection nature.com/articles/s4158… #journals #feedly