Xavier Trepat

New paper from the lab🎈. Introducing Micro Immune Response On-chip (MIRO), a device that replicates tumors and their microenvironment to better understand responses to immunotherapies (cyan=immune cells, red=cancer, green=CAFs). @IBECBarcelona

A thread of our new preprint 🧵👇 🤩

🚨 Second preprint of the week! We uncover the multiscale dynamics of active viscoelastic buckling in epithelia. We harness these mechanical instabilities for synthetic morphogenesis. Led by @onenimesa🙌. Theory by Marino Arroyo and team. biorxiv.org/content/10.110…

How to turn a layer of fibroblasts into a tulip 🌷? Check out our new pre-print on shape-programmable living surfaces. Led by @pauguillamat @IBECBarcelona biorxiv.org/content/10.110…

There’s tons out there about fibroblast #mechanobiology in disease. In @ConfinementLab’s new review in @aplbioeng, Yeji gives you the who/what/where/when/how/why of mechanosensitive fibroblast activation, from CAFs to FAFs and nearly everything in between! pubs.aip.org/aip/apb/articl…

(6/6) In summary, our new pipeline now allows us to dissect how such a complex multicellular system like a budding intestinal organoid achieves its mechanical stability. Congrats to our shared first authors Oliver and Kim for this amazing work biorxiv.org/content/10.110…

1/7: New paper alert! Excited to share our co-first author paper on Micro Immune Response On-chip (MIRO) a model that recreates the tumour-stroma interface for immunotherapy testing! @Oriol_MB and I wrote this thread to break it down for you. 👇🧵 More: shorturl.at/evTKS

Explore emerging research with field leaders @KeystoneSymp - Organoids: Engineering Innovative Approaches for Basic and Translational Insight. May 11-14 in Whistler, Canada! keysym.us/KSOrganoids #KSOrganoids

New preprint from the lab! We studied how single cells migrate up, down and about fibronectin gradients. Experiments by @icfortunato , theory by David Bruckner. Collaboration with @EdouardHannezo and @RaimonSunyer @IBECBarcelona biorxiv.org/content/10.110…

Sad to witness the implosion of #scitwitter, with all the great moments it brough us, but scientific exchange seems to be shifting for good.

Very nice focus issue @CurrentBiology on Physics and Biology. cell.com/current-biolog… Some of us wrote a perspective article on "Where physics and biology meet" led by @WallaceUcsf and Deborah Taylor. cell.com/current-biolog…

1/4 In our new concept paper in @BiolTheory, we elaborate an investigative approach that prioritizes the art of careful observation, the biological whole, and physical thinking in order to develop novel biological theories of morphogenesis. link.springer.com/article/10.100…

We wrote a fun review all about the different types of mechanosensing and the ways cells regulate these important processes. Check it out!

Thrilled to share that our paper on 3D traction force measurements of migrating immune cells (and growing axon growth cones) is now published in Nature Physics: rdcu.be/dU9Nj. Huge thanks to everyone who worked so hard to make this happen!

Finally, out in @Nature! A great team effort to address very constructive reviews. With @caldarellip1, Alexander Chamolly, @villedieuA_bio, Olinda Alegria, Carole Phan, and Francis Corson , with the support of @ERC_Research . rdcu.be/dTFJV

📢Paper alert📢 Great @Cluster3DMM2O collaboration with the group of @EvaBlascoPo on stimuli-responsive mechanical metamaterial now out in @ScienceAdvances. With @LiYunHsu, @claravamar_, @CA_Spiegel and X-less Santiago Gomez Melo and Falko Ziebert. Here a 🧵1/n

Hi, I’m David Brückner @d_brueckner. I’ll take you through how cells in a tissue can use information distributed by biochemical gradients to make decisions, and how we can measure such positional information.

Our latest is out!! 🙌Active shape programming drives Drosophila wing disc eversion | Science Advances science.org/doi/10.1126/sc… @PoLDresden @mpicbg @mpi_pks @csbdresden @_JFuhrmann_ @abhijeet095 @mpopov1c @carldmodes 🧵