Michael Gandal

New in @ScienceMagazine: Our paper mapping gene/isoform/splicing regulation at pop-scale during human #neurodevelopment. Major developmental shifts in #genetic reg., New colocalized risk genes at ~60% of #psych #GWAS loci. #PsychENCODE24 science.org/doi/10.1126/sc…

Important new meta-analysis shows no link between in-utero MPH, AMPH, or atomoxetine exposure and any NDD outcome. Great news for women hoping to keep taking their stimulants during pregnancy (though still slightly higher risk of gest HTN, abruption, etc) nature.com/articles/s4138…

New research from @ChildrensPhila’s Gandal Lab + the Lifespan Brain Institute shed light on the genetic underpinnings of complex neurodevelopmental & psychiatric disorders as part of the @NIMHgov's #PsychENCODE initiative. Learn more: ms.spr.ly/6019l4Jf5

The Gandal Lab hits 20k citations!! scholar.google.com/citations?user…

Phenotypic analysis of 11,125 trio exomes in neurodevelopmental disorders biorxiv.org/content/10.110… #biorxiv_genetic

Fascinating study comparing >200k veterans started on GLP-1R agonists for diabetes vs 1.2M started on other T2D meds, tracking 175 outcomes over 3.7 yr. 10-20% reduction in neuropsych outcomes, including schizophrenia, SUD rdcu.be/d6XEz

Awesome tools for complex trait genetics, a collection curated by Michel Nivard: github.com/MichelNivard/a… 🧬

The @Penn @ChildrensPhila Lifespan Brain Institute held its 2024 symposium, "Pathways to Psychosis," Nov. 4, featuring a line-up of lectures on risk mechanisms in #schizophrenia, #brainimaging in early psychosis, lived experiences, & more. Learn more: ms.spr.ly/6018WSMqe

Decoding sequence determinants of gene expression in diverse cellular and disease states | bioRxiv biorxiv.org/content/10.110…

Excited to share that denovo-db is now available on @ZENODO_ORG (doi.org/10.5281/zenodo…)! The new version of denovo-db contains >1 million de novo variants from published data on >70,000 individuals. After much thought, this feels like the right step for sharing with the…

Online Now: Large-scale map of RNA-binding protein interactomes across the mRNA life cycle dlvr.it/TDS2Qd

Excited to see the revised version of our paper now published at @CellGenomics led by @YSereb cell.com/cell-genomics/…

Really wild to see so many positive results for GLP1 drugs in large double blind RCTs — 30% decrease in COVID mortality jacc.org/doi/10.1016/j.…

What if Facebook actually followed the (sensible) advice of its own Llama3 AI platform on how to mitigate social media's exacerbation of our current mental health crisis:

New review from ⁦@coletrapnell⁩ summarizing major statistical inference methods applied to single-cell, spatial, perturbation data to study gene function in healthy and disease states ⁦@NatureRevGenet⁩ nature.com/articles/s4157…

📢 We're hiring! 📢 We have an immediate opening for a postdoc to work on neuroimaging-genetics at UCLA. Interested in linking large-scale MRI datasets with genomics and transcriptomics? Come work with us! Details 👉 hernandezlabucla.org/join RTs appreciated! 🔃

How do quantities of brain cells – the fundamental unit of life – differ in Alzheimer’s disease, schizophrenia and autism? Our work on cell-type proportion shifts using methylomics is just out in @ScienceAdvances #PsychENCODE @mikejg84 @DanielVo10 science.org/doi/10.1126/sc… 🧵