Zack Williams, MD, PhD

Finally landed in LA and checking out the places I'll be spending most of my waking hours inside as part of @UclaPsychRes. Proud to be a part of @UCLASemel and back on the best coast after my 12-year hiatus. Guess you can't keep this California boy away from tacos and the beach!

This recent Research Highlight from @hbwardMD discusses how single rTMS sessions with fMRI to probe mechanism are critical stepping stones that line the path toward highly effective neuromodulation interventions for substance use nature.com/articles/s4138…

1/ Just out in @NatureMedicine : we show the opioid system modulates ketamine’s effects in major depressive disorder, with naltrexone pre‑treatment reducing acute glutamatergic activity and acute antidepressant effects. nature.com/articles/s4159…

Individuals with more severe clinical #Alzheimer disease symptoms than their biological stage often have additional pathologies, suggesting the need to evaluate non-AD biomarkers for accurate diagnosis. ja.ma/44G6LNV

Our latest paper (since last week), Long read WGS boosts detection of causal variants. But long reads are a game changer WRT to resolving complex genetic variation and its functional consequences and regulatory effects. medrxiv.org/content/10.110…

Super cool new paper in @EpilepsyBehavi1 detailing a novel provocative test for functional/dissociative seizures (aka PNES) with built-in spell termination procedures that work! Definitely something I'm going to try out next time I'm in the EMU! sciencedirect.com/science/articl…

Grateful for this positive review of “Conversations in Critical Psychiatry” in the British Journal of Psychiatry by Tom Harrison.   Aftab “condenses an understanding of psychiatry that everyone working in the field would benefit from”   cambridge.org/core/journals/…

Daridorexant (Quviviq) improved all sleep outcomes in new, phase III RCT of mild sleep apnea, without causing daytime fatigue: pubmed.ncbi.nlm.nih.gov/40660750 These orexin antagonists are generally safer than traditional hypnotics.

Catatonia in Autism Spectrum Disorder: Analysis of Clinical Characteristics, Stressful Life Events, and Validation of the Attenuated Behavior Questionnaire (ABQ) - Psychiatry Research - Öksüzoğlu et al - 2025 sciencedirect.com/science/articl…

Knowledge in medicine and clinical psychology requires a careful triangulation of information obtained via multiple modes of inquiry: clinical observation, clinical trials, observational studies, patient reports, and basic research. The most robust conclusions show a strong…

The UBE3A-ATS antisense oligonucleotide rugonersen in children with Angelman syndrome: a phase 1 trial: nature.com/articles/s4159…

I am excited to share that my team here at the at the Social Connections and Treatment Lab at the Life Course Outcomes Program at the AJ Drexel Autism Institute, and we are looking for a full-time Research Associate! For more information and to apply: careers.drexel.edu/mob/cw/en-us/j… (1/)

Very cool special issue of @journalautism on "The Social Model in Autism Research." Some really valuable perspectives (and empirical work) inside! Couldn't even imagine a major autism journal printing this issue 6-7 years ago—how times have changed.

The National Academy of Medicine (@theNAMedicine) Shared Commitments provide common-ground expectations for the integrative benefits of learning health systems, which align science, incentives, and culture to facilitate continuous improvement. Full Sounding Board article:…

Playing Whack-a-Mole With the Uncertainties of Antidepressant Withdrawal Complacency is the wrong conclusion of a new debated study psychiatrymargins.com/p/playing-whac…

Delusional disorder, acute psychoses, psychosis not otherwise specified, and schizoaffective disorder have distinct genetic profiles from schizophrenia, bipolar disorder, and major depression. ja.ma/4lIeGkE

📣Prospective grad students with a clinical and/or research focus in autism—this is for you!📣 Check out our comprehensive database of autism research faculty—a unique resource to support your search! 🔗 abctautism.com/asd-research-f… #GradSchool #ClinicalPsychPhD #Autism

Glad to see this published: Trigeminal nerve stimulation as a 'semi-active' TMS control condition: Heart-Brain Coupling identifying 'sham' response to TMS. Implications for power calculation, future meta-analyses and TMS trial design. brainstimjrnl.com/article/S1935-… Great collaboration…

Today, July 9th, is the inaugural World Misophonia Awareness Day! If you’ve seen this word on my page and not understood it, now’s a perfect time to learn more ⬇️ MisophoniaDay.com Shoutout to @SoQuietOrg (and countless others) for organizing this! #MisophoniaDay

In older adults undergoing major noncardiac surgery, postoperative delirium was associated with a 3.5 times higher risk of death or major complications, a 2.8 times higher risk of death, and a 4 times higher risk of nonhome discharge. ja.ma/44hY5OO