Chloe Yap

How do quantities of brain cells – the fundamental unit of life – differ in Alzheimer’s disease, schizophrenia and autism? Our work on cell-type proportion shifts using methylomics is just out in @ScienceAdvances #PsychENCODE @mikejg84 @DanielVo10 science.org/doi/10.1126/sc… 🧵

Happy to share that our work applying precision mapping to individuals with depression sampled longitudinally over an extended period has been published this week in @nature. Brief recap of the main findings and their potential implications below. nature.com/articles/s4158…

This is the report of a novel autoimmune disorder, that causes specific deficiency of vitamin B12 in the cerebrospinal fluid (CSF) It's caused by autoantibodies against a B12 receptor, CD320, which transports B12 from the blood into the CSF What this means is that B12 levels…

Why are so many people with psychosis missed before their first episode? We studied over 1,500 patients to find out whether those missed by early intervention services show different early signs. Here’s what we found. 🧵👇

🚨Research Assistant job at @OxPsychiatry with @WrayNaomi and myself to start! Ideal opportunity to gain experience in Psychiatric Genomics working on clinically impactful projects 👉lnkd.in/gKq3TgvQ Please repost!

We are recruiting 1-2 new PhD students! If you know someone that might be interested in doing a PhD in psychiatric genetics in sunny Brisbane please tell them to get in touch 🙂

My lab and that of @JianZengR are recruiting postocs to work on various stat gen projects. There are 3 positions advertised. Please check them out and share within your networks. Thanks! nature.com/naturecareers/… Closing Date is Feb 28, 2025.

📣Big news! Our tag-team effort on common variants in rare neurodevelopmental conditions is now out in @Nature! 📣 Co-first authoring with the brilliant @qinqin_huang🌟—proof that teamwork does make the dream work. 💪 nature.com/articles/s4158…

The Qld Centre has launched! Watch below for my slightly-too-emotional launch speech…Thank you to all for their support! @QCIDD @3DN_UNSW @UQMedicine @DownSyndromeAu @qldhealth @CIDvoice @QDNltd @QCMHR

FDA approves first schizophrenia drug with a new mechanism of action since the 1950s tinyurl.com/34ceshw4 Karuna/Bristol Myers Squibb’s KarXT (Cobenfy), which acts on M1/M4 muscarinic acetylcholine receptors, expands the treatment landscape beyond dopamine-targeted drugs

Today, we’re going to play a game I’m calling “IT’S JUST A LINEAR MODEL” (IJALM). It works like this: I name a model for a quantitative response Y, and then you guess whether or not IJALM. 1/

NEW PAPER 📢 New study indicates that the new recombinant shingles vaccine could reduce the risk of #dementia compared to a previous vaccine. Led by @MaximeTaquet & funded by @NIHRresearch @OxHealthBRC the paper is published in @NatureMedicine. 👇👇👇 tinyurl.com/39sp6vxb

One additional job: 50% science coordinator, 50% research. My right hand person in organising SMARTbiomed activities - summer school, workshops, journal clubs, student liason. Variety. Needs content knowledge and organisation skills. Could be fun!

*Ten* 3-year post-doc/assistant prof jobs advertised for our Pioneer Centre for SMARTbiomed - address key questions in common complex diseases through development of new stat/comp tools & software. A new Denmark-Oxford collaboration. Critical mass! smartbiomed.dk/join-the-centr…

Not many people will read your PhD thesis, but if you completed your doctoral research at the ANU College of Science, then Tabitha Carvan has probably read one small part of it – the acknowledgements. What she found is a kind of poetry in the science. science.anu.edu.au/news-events/ne…

Really enjoyed contributing to @ruairirobertson's Biomes podcast together with one of my all-time favourite scientists, Alan Walker @_Faecal_Matters. It’s also one of my favourite topics: Prevailing myths in the microbiome world and why it is important to combat them.

New Oxford-Aarhus-Copenhagen collaboration - not yet launched - 2 postdocs, 2 senior postdocs and postdoc coordinator in Oxford. Jobs 173031-3 at jobs.ox.ac.uk Methods-focussed in group Holmes, Visscher, Evans, Nicholson, @cwcyau, @ten_photo etc, Denmark ads soon

🔥 Finally! Just launched the R color palette finder 🚀 🎨 Explore 2500+ palettes, see them in action, get the ggplot2 code. ➡️ r-graph-gallery.com/color-palette-… 🙏 @joseph_barbier and @Emil_Hvitfeldt for the paletteer package! Useful? Bug? Feature request? Let me know!

Exciting news from our latest research! We've developed a plasmalogen score (Pls Score), a new biomarker that could change how we assess metabolic health. authors.elsevier.com/sd/article/S23… @BedimoBeyene @BakerResearchAu

There's been amazing coverage of our new paper @Nature nature.com/articles/s4158… but I wanted to put together a walk-through (and make this accessible as possible). It's a bit long so get a cup of tea! The full version is open access so pls do have a read if you are interested...

Beautiful work Chloe, congratulations