Abdel Abdellaoui

In every civilization, people end up sorted into levels of socio-economic status (SES). We explore the history, present, and future of scientific research on the complicated relationship between SES and DNA in @NatureHumBehav 💰🧬🎓 Link: rdcu.be/efacK Thread below 👇🏽

A single-authored research highlight paper from our PhD student Liyang SONG is out now in Nature Review Genetics. @liyang_song

Around 6,500 years ago, hunter-gatherer communities across Eurasia were settling down and living with livestock — and the animals’ diseases came along for the ride go.nature.com/44Ftutl

‘Genetic Risk Effects on Psychiatric Disorders Act in Sets’, the title of our new preprint on @medrxivpreprint! This huge collaborative effort advances our understanding of psychiatric genetic architecture and emphasizes the importance of looking beyond additive effects. 🧵1/n

Interested in love and mate preferences? Our dataset includes responses from 117,293 participants across 175 countries. You're welcome to use it for your own research! Paper and dataset linked below. @ with amazing collaborators from the large-scale cross-cultural consortium <3

Psychiatric Genetics Beyond Heritability: Q&A with Michel Nivard “We look for genes as a means to an end—biology, epidemiology, and etiology of complex human outcomes.” psychiatrymargins.com/p/psychiatric-…

My first paper using SNP data was really just a description of all the patterns I ran into while cleaning the data: nature.com/articles/ejhg2…

The HLA region is key to human health, but is often excluded in large-scale GWAS. Informing future studies on its influence, @AJHGNews' latest article reports HLA haplotype-based associations across thousands of diseases: bit.ly/4lrJiXT #ASHG @jkpritch

Effects of ancestry, agriculture, and lactase persistence on the stature of prehistoric Europeans biorxiv.org/content/10.110… #biorxiv_genetic

On behalf of the CNV analysis workgroup of the @PGCgenetics I'm pleased to share our latest paper "Psychiatric disorders converge on common pathways but diverge in cellular context, spatial distribution, and directionality of genetic effects" 🧵1/N medrxiv.org/content/10.110…

Investigating potential causal effects of maternal smoking on offspring handedness using a proxy gene-by-environment (GxE) Mendelian randomization design out today: link.springer.com/article/10.100… with Daisy Crick @mendel_random @medland_sarah

New preprint with Guy Sella on the question: what is polygenicity? biorxiv.org/content/10.110…

🚨 Preprint Alert 🚨 "Major depression and atherosclerotic disease: linking shared genetics to pathways in blood, brain, heart, and atherosclerotic plaques. " 🧠🫀🩸 The title says it all. Great collaboration with Sander van der Laan. 📄 Read it here: bit.ly/4eTM8T2

🚀 Just launched: A free, open AI chatbot that answers any science or health question—based on real academic research. No paywalls. No BS. Just evidence. Try it out, share it, and send feedback to [email protected] nodes.desci.com Built by @DeSciLabs 💡

🔔 LGN Summer Lecture! Wed 16 Jul @ UCL Bloomsbury. @dr_appie (Amsterdam UMC) on “Genetic Architecture of a Social Construct”. ☕ 15:30 coffee | 16:00 talk | 🤝 17:00 networking. Members: check your email for the invite from the LGN mailing list.

Yayy that’s all scicomm talks done! Thank you for hosting me at Amsterdam @dr_appie

🚨New preprint is out! How do genetic effects on complex traits change with age? In this work, we compare different approaches to obtain age-varying genetic effects, and show how design and modeling choices can impact the conclusions we draw. shorturl.at/17snd A thread 🧵

How does art contribute to science? My friend Eliza Wolfson and I 'talked' about this in a comic! I'm preparing some lectures for my trip to NL to talk about visual scicomm and this is such a nice excuse to look back at my body of work rather than just the current deadline.

Delighted to share the preprint on the largest obesity GWAS to date! GWAS from >2 million participants Key: ✳️13% increase in loci discovery ✳️Identified 11 obesity genetic clusters (endotypes) ✳️Obesity management should be as diverse as the condition itself Thread👇

Forty years after the first effort to extract mummy DNA, researchers have finally generated a full genome sequence from an ancient Egyptian go.nature.com/3TYRum9

July issue of @TrendsMicrobiol is now online, with our review by Xinming Xu @neftalyl @CajaDinesen @AdelePioppi on Composing a microbial symphony and a matching cover illustration by @Lizah_Aart #SynCom #PlantMicrobiome #MicrobiomeEcology at @LeidenBiology