meg clark
@megclarks
vmd-phd candidate @Penn in the Henao-Mejia lab.
.@Penn scientists have developed a new method for tracing the lineage and gene expression patterns of metastatic cancer at the single-cell level penntoday.upenn.edu/news/pinpointi…
ft. @megclarks, Walter Mowel, @MFMich1, Leonel Joannas, @Notorious_MHC, Isabel Erickson, Jorge Henao-Mejia (@PennPathLabMed), Lexus Johnson, @andyjminn (@UPenn_I3H), @rakez_krish, @delafuentelab (@PennPsych) & @ksimeono (@PennVet) @ImmunityCP cell.com/immunity/abstr…
Thrilled to share our paper on how mitochondrial complex IV remodeling can modulate TAM functions and promote anti-tumor immunity! with @ksimeono, @MFMich1, @Notorious_MHC, @rakez_krish, @delafuentelab, @andyjminn, @JHMLab and those not on X! Out now in @ImmunityCP 🎉
Online now: Mitochondrial complex IV remodeling in tumor-associated macrophages amplifies interferon signaling and promotes anti-tumor immunity dlvr.it/TLf6cn
congrats Jen! 🎉🎉🎉
In vitro models of CD8 T cell exhaustion make high-throughput interrogation easy, but can they be used to discover real Tex biology with therapeutic relevance? Read to find out! In our new work from the @EJohnWherry lab, out now at @SciImmunology, we... bit.ly/45yOFMB
3D genome organization of #ILCs🧬 @NatImmunol ft. @MFMich1, John Tello-Cajiao, @walter_mowel, Aditi Chandra, @ysora90, Leonel Joannas, @megclarks, Monica Jimenez, Jasmine Wright, @patrlundgren, @ChristophThaiss, @golnaz_v & Jorge Henao-Mejia @Penn_IFI go.nature.com/3SU353J
New paper alert! We (@KingOfPathogens) are excited to publish this story about cDC1s controlling the immune response in the omentum. Please indulge a short-ish 🧵 below (1/8): science.org/doi/epdf/10.11…
congrats @dachri0 !!! for all of the omentum lovers out there - this paper is a must read!
Macrophage lovers this ones for you! And anyone that's ever done an ip injection. Fat associated lymphoid clusters often regarded as primitive can do everything SLOs can. See omenta-philes @LucyHJackson_J @ImmunobiologySG @dachri0 science.org/doi/epdf/10.11…
So proud of #twitterlessMegha for this beautiful work! Such a cool story about the highly specific antiviral lncRNA ALPHA! Check it out!
Macrophage lovers this ones for you! And anyone that's ever done an ip injection. Fat associated lymphoid clusters often regarded as primitive can do everything SLOs can. See omenta-philes @LucyHJackson_J @ImmunobiologySG @dachri0 science.org/doi/epdf/10.11…
woot woot! go @mexivet !!!!
Jimenez, Henao-Mejia et al @Penn_IFI @PennPathLabMed show that the miR-181 family is downregulated in IECs from human #IBD patients and in mice w/ #colitis, a process that is critical for the development of severe colonic #inflammation bit.ly/3RLwMmH @megclarks @MFMich1
Congrats @MFMich1 and colleagues / @JHMLab !!! Wonderful story and so happy to see it out :)
Michieletto et al. provide a detailed characterization of the 3D genome architecture of ILCs, discovering a unique 3D DNA topology at the Id2 locus #3D_ILCs, #3D_ILC2s. @Penn_IFI, @PennPathLabMed, @MFMich1, @golnaz_v, @megclarks. rdcu.be/cUQBs
happy gotcha day, Nugget! I got this chunky little man 7 years ago, today! 🥰🥳
go @M_S_Hakeem !!!! 🤩🥳
Nice seminar today by @M_S_Hakeem on exhausted T cells with infectious enthusiasm. And he managed to get in something about imposter syndrome which is great for the students to hear - thanks for joining us for Easton Seminars! Alumni from @EJohnWherry and @naglaa_shoukry.
come see some awesome science from my pal @ksimeono tomorrow!
Kamen Simeonov @ksimeono from the Lengner lab defends tomorrow!
go kamen @ksimeono !!!! 🎉🎉🍾
Congratulation to Kamen Simeonov! 2021 winner of the Kaushal Family Award in Genetics @ksimeono @CAMBUpenn @pennbgs
Online Now: Lineage tracing reveals metastatic dynamics dlvr.it/S2SmNF
Beautiful work and some unexpected findings in macsGESTALT lineage tracing of metastases and EMT by the uber-talented @ksimeono, not to mention some stunning data-viz!
Very happy to share our paper exploring cancer metastasis via "lineage recording" or "CRISPR lineage tracing" w/ Chris Lengner, @JShendure, @aaron_mckenna, @chinabyrns, @megclarks, Bobby Norgard, @bethkarenmartin & Ben Stanger authors.elsevier.com/c/1dDNc5TA51Vy…
Congrats to @pennvet LengnerLab(notonTwitter) @ksimeono @megclarks @JShendure and colleagues on this beautiful story on single-cell lineage tracing of individual pancreatic cancer cells to reveal cell-intrinsic properties of aggressive metastatic clones. sciencedirect.com/science/articl…
Thrilled to share this gorgeous work by @ksimeono on lineage tracing of metastatic cancer. Excited for future collaborations with such a brilliant scientist and friend!
Online Now: Single-cell lineage tracing of metastatic cancer reveals selection of hybrid EMT states dlvr.it/S1TyY9
Very happy to share our paper exploring cancer metastasis via "lineage recording" or "CRISPR lineage tracing" w/ Chris Lengner, @JShendure, @aaron_mckenna, @chinabyrns, @megclarks, Bobby Norgard, @bethkarenmartin & Ben Stanger authors.elsevier.com/c/1dDNc5TA51Vy…