David Christian, Ph.D.
@dachri0
Immunologist and engineer. UPenn since 2003: Discher and Hunter Labs. Studying immune response during toxoplasmosis. Single dad. Go Cats.
.@iancohn @striepenlab @KingOfPathogens et al. show that intestinal cDC1s have distinct roles in shaping CD4+ T cell responses to #Cryptosporidium. hubs.la/Q02TJsqr0 📘 In our #Cytokines collection: hubs.la/Q02TJtq20 #cytokines2024
Kevin Wood was a wonderful human being and he is gone way to soon, like a shooting star. I will miss him. Support Future Biophysicists in Kevin's Memory gofund.me/b8bff582
It still hasn't sunk in that I was at the "old folks" table for dinner...
Delighted to have my image on the cover of @mbiojournal Isn't the #intestine pretty?! Want to see more? Check out our publication that goes with it! @striepenlab @KingOfPathogens journals.asm.org/doi/10.1128/mb…
Preview of some great Global Parasitology Seminars to look forward to this coming semester! @TrendsParasitol @BSPparasitology @AS_Para @parasitesrule @AmSocParasit @ParaFrap @pennbgs @womeninmalaria @pennvet @bloodSparasites @PiParasitology
Hey @jkagan1 who likes cytokines and mRNA vaccines? @emilyaunins @anthonyphan with @MgAlameh @dachri0 @KedlRoss @WeissmanLab explore how IL-12 mRNA can be used to diversify and improve mRNA vaccine induced CD8 T cell responses - takes a village biorxiv.org/content/10.110…
Check out our new paper for a window into Cryptosporidium's life in the gut #cryptosporidium #intestine #MicroscopyMonday
Read our new paper: Cryptosporidium impacts epithelial turnover and is resistant to induced death of the host cell by @BethanWallbank out today in @mbiojournal. Great team effort with @RyanPardy2 @KingOfPathogens @BrodskyIgor journals.asm.org/doi/10.1128/mb… Infected = not apoptotic:
Read our new paper: Cryptosporidium impacts epithelial turnover and is resistant to induced death of the host cell by @BethanWallbank out today in @mbiojournal. Great team effort with @RyanPardy2 @KingOfPathogens @BrodskyIgor journals.asm.org/doi/10.1128/mb… Infected = not apoptotic:
New record for the lab (and not a good one). Revision of latest manuscript contains 79 new figure panels to address reviewers’ questions. To quote Hidde Ploegh: End the tyranny of reviewer experiments!
In its 184 year history @JExpMed has not published a manuscript on Cryptosporidium. Today, an injustice righted with @iancohn and @striepenlab using transgenic parasites to understand how cDC1s regulate T cell–mediated resistance to Cryptosporidium rupress.org/jem/article-ab…
Why do activated T/B cells wait to divide? Why is there heterogeneity in their daughter cell responses? How do we find peace in these troubled times? Check the Bailis Lab’s FIRST PAPER (🎉) for insight into 2 of these 3 questions! science.org/doi/10.1126/sc…
⚡️New preprint out! #Immunology #biophysics 1/ We show hidden functional immune cell states based on collective membrane properties, which are not directly visible via cell surface markers. biorxiv.org/content/10.110…
Who likes enteric pathogens and the DC and CD4 T cells that control them? @iancohn and @striepenlab find a role for DC1 in supporting CD4 responses to Crypto. Terrific use of transgenic parasites to track priming, effector responses and parasite control. biorxiv.org/content/10.110…
Kandice Levental and Ilya Levental to Receive 2024 Avanti Award in Lipids ow.ly/npZi50PLIKI
Huzzah!
NEWS: Kentucky will play Penn on December 9th at the Wells Fargo Center in Philadelphia, according to a source. rb.gy/s4rvs
Want to learn more about CD8+ T cell responses during infection in the intestine? Check out our preprint! biorxiv.org/content/10.110…
Know lots of Penn Engineering alums (@Lola_UMich @LeventalLab) that will be sad to hear this: inquirer.com/news/magic-car…
“…And when our work is done, Our course on earth is run, May it be said, ‘Well done Be thou at peace.’ E'er may that line of gray Increase from day to day Live, serve, and die, we pray, West Point, for thee.” - West Point Alma Mater
Looking forward to chatting about the best cytokine (IFNg) and parasite (cryptosporidium) combination today at 2:30! Come see me at poster 503 at #AAI2023