Lisa Baumgartner

How does the HP1 variant Rhino achieve its specific localization that is so important for the #piRNA pathway?🪰 The final version of our answer is out @eLife showing that the ZnF protein Kipferl balances the competition of different selfish elements for 🦏 doi.org/10.7554/eLife.…

Cells turn genes on and off with the help of transcription factors, but binding to DNA is complex. @marco_heffler, @RalphSGrand and others in the @SchubelerLab found that these factors act more variably than expected, sometimes displacing nucleosomes only in certain regions 🧬

To pioneer or not to pioneer...! Or is it a bit more complicated after all? Check out the latest from the @SchubelerLab, a huge effort by @marco_heffler and @RalphSGrand 🎉 (featuring the first small snippets of my PD work 😊)

It is challenging to study the ability of transcription factors to engage their motifs in the cell. We tried to address this in our new study together with Marco (@marco_heffler), @SchubelerLab, and @FMIscience: cell.com/molecular-cell…

New Study Alert! A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin biorxiv.org/cgi/content/sh… #biorxiv_molbio

Excited to share our latest preprint. Lead by Sevi (@biosevi) we asked how transcription factors (TFs) with short and abundant motifs drive specific cell fates. Our test cases: Two bHLH factors that bind to seemingly similar E-boxes. 1/7 biorxiv.org/content/10.110…

Congratulations to Julius Brennecke for securing one of this year’s @ERC_Research Advanced Grants! Julius will study the arms race between transposons and host genomes. #ERCAdG More here: oeaw.ac.at/imba/research-…

I’m beyond excited to present my postdoc work with @plaschka_lab and @JuliusBrennecke at @IMPvienna @IMBA_Vienna . We uncovered a mechanistic framework for a general and conserved mRNA nuclear export pathway. A thread: 1/x

We're looking for a Managing Director of our scientific core facilities - details: viennabiocenter.org/fileadmin/user…. Come work with us - 6 basic research institutes & 40 biotech companies, >2000 scientists from 85 nations - at the vibrant @viennabiocenter in Vienna, Austria. Please RT.

Over 4 years in the making, I am excited to share our pre-print on the “In-cell structure and snapshots of copia retrotransposons in intact tissue by cryo-electron tomography”. We used cryo-ET to resolve the copia capsid structure to subnanometer resolution inside cells. A 🧵

This month we had the last happy hour in our current building. The event marked the end of an era, complete with piñata smashing, poster graffiti and intense Jenga battles🎊Exciting times ahead as we gear up to move to a new home soon! Keep watching this space for more🏢✨

@PetersLabFMI: Excited to share our latest preprint lead by Greg Fanourgakis (@Grigo_Fanou). Key findings are that DNA methylation modulates nucleosome retention in sperm and H3K4 methylation deposition in early mouse embryos. biorxiv.org/content/10.110…

Yay! Super happy to see my paper out in @emboreports. Thanks to all the people involved in the work, the reviewers and the editor. For a summary, check out the interview below 👇 or this threat 🧵: x.com/llorenzoorts/s…

Exciting news! Our latest research on "Cell type directed design of synthetic enhancers" has been published in @Nature. We've harnessed deep learning to design enhancers with cell-type specificity. Find our paper here: nature.com/articles/s4158…. Highlights below: [1/n]

We are very excited to present a major breakthrough achievement – the de novo design of synthetic enhancers for selected tissues in fruit fly embryos in vivo using deep- and transfer learning, @deAlmeida_BPet al published today in @Nature nature.com/articles/s4158…. Thread 👇(1/N)

I'm actively looking for a post-doc position in reproductive/dev bio and have a particular interest in understudied/endangered species linkedin.com/pulse/imployab… please share! #postdoc #postdocjobs

The @juliusbrennecke group shares an update on last year's Kipferl discovery by @lisababalisa.

Evolutionary adaptation of the chromodomain of the HP1-protein Rhino allows the integration of chromatin and DNA sequence signals biorxiv.org/cgi/content/sh… #bioRxiv