Ralph Grand
@RalphSGrand
Junior Group Leader @ZmbhH | Postdoc FMI @SchubelerLab | Interested in all levels of gene regulation in mammalian chromatin and the outdoors.
New preprint from the Lab at @cabimer. We present PLAMseq, using TurboID to do like ChIPseq and proximity proteomics in the same protocol with extra powers like mapping protein interactions in the genome. biorxiv.org/content/10.110…
‼️‼️📢📢 Job Alert! Our lab is seeking for a PhD student to work on the proteostasis of early mammalian development using stem cell models and the embryo. If you are enthusiastic about cell and dev biology, please apply!
With this new funding, we’re hiring PhDs and #postdocjobs Our #ERCAdG studies on the role of #RQC #ribosome #ubiquitin in #neurodegeneration will include using iPSCs, i-neurons, mammalian TC. The lab also has ongoing projects on #mitochondria and bacterial RQC.
Thrilled and honored to receive the #ERCAdG! This will fund us for the next 5 yrs for groundbreaking research My project SuTra focuses on the Surveillance of Translation, from sensing #ribosome stalling to #RQC. We aim to learn how defective surveillance causes neurodegeneration
We're thrilled to introduce PromoterAI — a tool for accurately identifying promoter variants that impact gene expression. 🧵 (1/)
🚨 New method alert! We developed HiddenFoot, a physics-inspired approach to decode single-molecule footprinting data and infer TF, nucleosome, and RNA Pol II binding profiles on individual DNA molecules. One molecule at a time! biorxiv.org/content/10.110…
Nature research paper: Chromatin loops are an ancestral hallmark of the animal regulatory genome go.nature.com/4d1RR8g
Delighted to share our latest work deciphering the landscape of chromatin accessibility and modeling the DNA sequence syntax rules underlying gene regulation during human development! biorxiv.org/content/10.110…. Read on for more 🧵 [1/16]
Can metabolism regulate more than bioenergetics during human development? Our new study says YES! We show that metabolism influences cell fate choice in human naïve pluripotent stem cells, histone acetylation, and trophectoderm maturation. rb.gy/spqr9j @NatureCellBio
Excited to share our pre-print on the molecular architecture of heterochromatin in human cells🧬🔬 w/ @jpkreysing, Johannes Betz,Turoňová lab, @MarinaLusic, Hummer lab, @Beck_Laboratory, @MPIbp 🔗 Preprint here: doi.org/10.1101/2025.0…
I am super proud to share the first Andergassen Lab preprint! Here, we introduce a new framework to decode the non-coding genome, led by the outstanding work of @HasenbeinT and co-authors @sarahhoelzl, Stefan Engelhardt @TU_Muenchen @dfg_public @trr267 👇🧵
So excited to announce that our study on the development and evolution of pallial cell types and structures in birds led by @BassiZaremba is now out in @ScienceMagazine! science.org/doi/10.1126/sc… PS: this is our last post here – please follow us to where the sky is blue!
#CellPlasticity—the ability of cells to change their identity—is vital for tissue growth and repair. But when it goes unchecked, it can fuel #cancer. Our latest study examines how to block #LiverCancer by actively suppressing plasticity. nature.com/articles/s4158… #CancerBiology
📣 #EMBLSingleMolecule is open for registrations! Our aim is to catalyse the emergence of a new generation of mechanistic models of the regulation of genes across each steps of the central dogma. 🧬🔍 📜 Submit your abstract by 8 April! 📅 15 – 18 July 2025 📍 EMBL Heidelberg
Get in touch if you are passionate about science and want to learn more about #Epigenetics in sex differences of human disease
EMBO Postdoctoral Fellowships support internationally mobile postdoctoral researchers in Europe and around the world. Apply here (next cut-off date is 14 February): embo.org/funding/fellow… #ResearchFunding #LifeSciences
‼️⏰️📢 Only one week to apply for a PhD position in our lab. More info: iribhm.org/anchel-de-jaim…
🚨 🚨 🚨 Job Alert! I am currently opening my research lab at @iribhm_ulb @ULBruxelles in Belgium and I am seeking for an enthusiastic PhD candiate to study cellular stress across mammalian development and lineage specification! If you are interested, info below. Please RT!
Get in touch if your interested to study functional genomics and/or computational biology with us, lots of cool projects in the lab
EMBO Postdoctoral Fellowships support internationally mobile postdoctoral researchers in Europe and around the world. Apply here (next cut-off date is 14 February): embo.org/funding/fellow… #ResearchFunding #LifeSciences
One month until the CSHL Biology of Genomes abstract deadline! My all-time fav meeting, and one of the few covering genomics broadly. We have a ✨🤩 lineup of speakers, but it's the abstract talks & posters that make the meeting - send us your best work! meetings.cshl.edu/meetings.aspx?…
Out just now at @NatureComms and a great start into the New Year: we reveal how yeast cytoplasmic γ-TuRC is assembled and activated by dimeric CM1 motifs of the receptor protein Spc72 and how the microtubule polymerase Stu2 binds to promote MT assembly. nature.com/articles/s4146…
We have an opening for a PhD student to join our lab @kitz and @DKFZ! 🧠 Are you interested in using cerebellar organoids to model pediatric brain cancer? 👥 Like working in an international team? 🎓 Already/will have your MSc? Please apply by Jan. 9th: jobs.dkfz.de/en/jobs/167299…