Kuldeep Kumar
@kkumar_iitkgp
Postdoc, CHUSJ. Investigating the impact of genomic variants on human brain, and link to psychiatric risk. IIT-Engineer-ISRO-Neuro-Genetics. Data --- Pattern.
We are excited to share the pre-print of our work: “Cortical differences across psychiatric disorders and associated common and rare genetic variants.” doi.org/10.1101/2025.0… Huge thanks to all the participants for their data. And to the amazing co-authors. A summary 🧵
Our work out as pre-print. Cortical differences across 8 psychiatric disorders and associated common and rare variants. I will be presenting this as an oral presentation @SOBP this Thursday afternoon. Thanks to all the participants, and co-authors. A detailed 🧵 coming soon.
Getting granular on immune dysfunction in neurodegenerative disease: Single-cell spatial proteomic mapping of microglia in the brain from Alzheimer's disease and in controls nature.com/articles/s4159…
Mapping human thalamocortical connectivity with electrical stimulation and recording | Nature Neuroscience nature.com/articles/s4159…
Introducing our latest milestone on conversational diagnostic AI g-AMIE arxiv.org/abs/2507.15743 To harness AI's abundant potential in diagnosis and treatment, we need ways for licensed professionals to oversee and own responsibility for safety-critical decisions. In clinical…
Astrocytes connect specific brain regions through plastic gap junctional networks biorxiv.org/content/10.110… #biorxiv_neursci
An exciting collaboration is underway. Neuromatch is partnering with @_TheTransmitter to serve the computational neuroscience community and help connect neuroscientists across all career stages. Sign up for our joint quarterly newsletter: buff.ly/wZLH6k8
Out now in @natBME: We explore how rare high-effect gene-coding variants (#CNVs) shape brain architecture and influence cognitive and socio-behavioral traits in adolescents (#ABCD). nature.com/articles/s4155…
The mantra “location, location, location” isn’t just about real estate. For life scientists, more than 50% of their productivity can be attributed to the institution where they work, according to a new study. @ScienceCareers scim.ag/44V9Vxo
Peering into mitochondria - gorgeous life patterns! The parallel infolding are "cristae" where respiration and energy transformation happen The purpose of breathing is to bring oxygen to your cristae
Not sure which measure of network coupling to use in your fMRI analysis? Peep our latest PP led by K Pavlovich with @jchrispang comparing 10 different FC (+1 DCM) metrics in terms of robustness to motion and sensitivity to brain-behaviour correlations: tinyurl.com/yc3x68yv
Calling all early-career researchers!! @_TheTransmitter & @neuromatch want to know: what kinds of resources do early-career researchers need? Share you thoughts anonymously at the link below: thetransmitter.org/early-career-r…
Partnership between @davidrliu, @jacksonlab, and rare disease group @RAREH0pe leads to first use of prime editing for a brain disease that reduced symptoms, extended lifespan in mice, offering hope for other rare genetic diseases. broad.io/Prime-AHC
An exciting collaboration is underway. @_TheTransmitter is partnering with @neuromatch to serve the computational neuroscience community and help connect neuroscientists across all career stages. thetransmitter.org/neuromatch-par…
A landmark work by PGC CNV working group, accompanied by an excellent thread by @sebatlab
On behalf of the CNV analysis workgroup of the @PGCgenetics I'm pleased to share our latest paper "Psychiatric disorders converge on common pathways but diverge in cellular context, spatial distribution, and directionality of genetic effects" 🧵1/N medrxiv.org/content/10.110…
On behalf of the CNV analysis workgroup of the @PGCgenetics I'm pleased to share our latest paper "Psychiatric disorders converge on common pathways but diverge in cellular context, spatial distribution, and directionality of genetic effects" 🧵1/N medrxiv.org/content/10.110…
I received some old microscopy slides from 1800s, when at-home microscopes made it possible to look at hidden worlds of diatoms, polycystina + other teeny tiny things. I made this website so people today can take a look too: microspeci.men Enjoy! #scienceisforeveryone
Together we go farther. Thanks to a partnership with @ASAP_Research and @MichaelJFoxOrg, the @AllenInstitute's ABC Atlas now includes #ParkinsonsDisease data from 3 million brain cells from 9 regions. This is the first time Parkinson’s data has been included in the Atlas. It…
The ABCD-ReproNim Course is back! ✨ abcd-repronim.org ✨ Have you previously worked with ABCD data? Apply to be a teaching fellow and receive a $5K stipend and $2K travel award. Deadline is August 1!
‼️Alert‼️Massive open dataset release!! The world’s largest proteomics dataset for neurodegenerative disease, including: * 250M+ protein measurements * 35,000 biosamples * 23 contributing cohorts * +50 harmonized clinical variables * AD / PD / FTD / ALS / Normal Aging 1/
Analyses from the largest neurodegeneration focused proteomics database - the Global Neurodegeneration Proteomics Consortium @_neuroproteome are published today in @NatureMedicine and @NatureAging The findings reveal unique protein biomarkers that correlate with…
Can AI reveal the risk and co-pathology of multiple neurodegenerative diseases from just a single blood sample? We explored the AI-based diagnostic power on a massive sample (N=17,170) and high-rank plasma proteomics data. medrxiv.org/content/10.110… #MedSky #neuroskyence #neurosky…
At least 1.7 million babies in India are born every year with birth defects, many of which are due to genetic conditions. Almost 1 in 250 children has a treatable genetic disease. Yet, genetic screening at birth almost does not exist in the public healthcare system in India.