Dr. Kaia Mattioli
@kaia_mattioli
postdoc, feminist @HarvardMed @BrighamResearch // generally fascinated by genomes // big fan of reality television, good writing, crosswords, & cats // she/her
our work on the molecular differences between transcription factor isoforms is out now in @MolecularCell! key point: 2/3rds of TF isos differ in important properties like DNA binding & transcriptional activity many are "negative regulators" that are misexpressed in cancer
T cells do the heavy lifting when it comes to the anti-tumor action of checkpoint immunotherapy. But do antibodies play a role too? That’s the question @yile_dai looked to answer in his thesis work, out today in @Nature! 🧵below nature.com/articles/s4158…
unreasonably sad that Aliquots, our building cafe with an incredible name and decent donuts, closed for good unceremoniously 😭 it's been a reliable snack source for me for 11 years and it's just.... boarded up!!
New ENCODE4 long-read RNA-seq transcripts track for hg38 and mm10. Triplets (e.g. [1,1,3]) indicate start site, exon combination, and stop site for each transcript. Enrichment scores show how these change across tissue and cell line samples. Read more: genome.ucsc.edu/goldenPath/new…
We're live! Manifold Bio's new website is here: manifold.bio Inspired? We're growing—join us. Special thanks to @bunsenstudio for articulating our vision and Javelin Tea Creative (javelinteacreative.com) for capturing the spirit of our team. #Hiring
getting weirder and weirder to show up at work every day as a researcher at a university and pretend we're not witnessing the active dismantling of American research universities
In an unprecedented move, the NIH will soon disinvite dozens of scientists who were about to take positions on advisory councils that make final decisions on grant applications for the US agency, Nature has learnt. go.nature.com/3TEAgdN
tell me you're writing a review without telling me you're writing a review
More than 2700 3′UTRs are highly conserved. These 3′UTRs are essential components in mRNA templates, as their deletion decreases protein activity without changing protein abundance. Highly conserved 3′UTRs help the folding of proteins with long IDRs. biorxiv.org/content/10.110…
Doing a postdoc to get a tenure-track faculty position
What's it called when you're delusional but self aware
One thing that really bothers me with the new "virtual cell" terminology is that is currently largely focused on a very narrow definition of models that can predict effects of trans perturbations (gene dosage, drugs etc) on gene expression. 1/
watching my partner be a dad these past 16 months has been the greatest joy of my life. happy Father's Day @PierceOgdenJ
Endometriosis is an incredibly interesting disease 5k words, 23 minutes reading time covering one of the strangest conditions ive ever heard about link: owlposting.com/p/endometriosi… very grateful to @shilpap_ for initial inspiration for this piece + reviewing it!!
I’m going to rewrite all my best papers and call them Sri’s version to regain copyright control.
Manifold Bio has a new look! And we're hiring! Checkout the careers page at manifold dot bio.
Today in @Nature we report a systematic strategy to activate & identify gene sets in plants. We identify 8 new genes from the yew tree's Taxol biosynthetic pathway, enabling us to engineer tobacco with 17- & 20-gene pathways to Taxol precursors baccatin III and dBz-deoxy-Taxol. a…
Synthetic biology could enable new types of programmable therapeutics. Our new preprint introduces synthetic protein circuits that selectively trigger cell death in Ras-mutant cancer cells, with interesting advantages compared to existing approaches. biorxiv.org/content/10.110…
Plasmid-based reporter assays are the bedrock of regulatory genomics. But a basic question has gone unanswered for decades: Do chromatin architectures form on plasmids transfected into mammalian cells—and does it matter? We finally have answers. biorxiv.org/content/10.110…
extremely normal times I see
The recent post from the NCI account was done without authorization by a career official in an attempt to undermine the Trump administration. Let’s be clear: there is no pause in NCI’s communications and NCI will continue to share vital cancer research with the public. The Trump…