John Janetzko
@jjanetzko
Asst. Prof. Univ of Colorado @CU_BMG. Chemist, sometimes structural biologist, bike racer 🚴🏼♂️, 👦 & 🐶 dad, 🇨🇦, 🎓 Stanford/Harvard/UToronto.
Well, it's official. My wife I are both joining the faculty at the University of Colorado @CUAnschutz this summer! I will join the Dept of Biochemistry & Molecular Genetics @CU_BMG & she will be joining the Div of Cardiology @CUCardiology and the Cancer Center @CUCancerCenter
T cells do the heavy lifting when it comes to the anti-tumor action of checkpoint immunotherapy. But do antibodies play a role too? That’s the question @yile_dai looked to answer in his thesis work, out today in @Nature! 🧵below nature.com/articles/s4158…
This user agreement is absolutely wild. You have to sign away your "knowledge, experience, concepts, ideas, and know-how" that the company "may retain and use". Just remember when something is "free", YOU are the product.
Introducing Latent-X — our all-atom frontier AI model for protein binder design. State-of-the-art lab performance, widely accessible via the Latent Labs Platform. Free tier: platform.latentlabs.com Blog: latentlabs.com/latent-x/ Technical report: tinyurl.com/latent-X
Inspired by @mbeisen I've begun an experiment in open science. We are sharing our ongoing work on psychedelic signaling here: open.substack.com/pub/zendudest/… I've decided to make this 'open' as the experiment are of immediate interest to the field and I'll write them up later.
Tomorrow the House Committee on Science, Space, and Technology will host “The Things We’ll Never Know: A Science Fair of Canceled Grants”. Scientists will be sharing their story and discuss their now-canceled research grants. This event is open to the public and to the press.
🧬 AlphaFold DB is aging, as all DB do. 575 / 20,504 human proteins now mismatch UniProt, while zebrafish discrepancies are at 43% 😅 Static structure banks drift as sequences evolve, risking wrong drug‑design templates
Mike Johnson would hate for you to know that nearly 40% of his district is on Medicaid. Or that 1.6 million Louisianans — about 35% of the state — rely on it. It would be terrible if this information went viral.
The U.S. built the world’s greatest engine for biomedical research. But a 40% cut to NIH isn’t budget reform, it’s dismantling of the system that will not recover. And let's be clear: Industry won't replace it and philanthropy cannot sustain it.
I agree with the “no grant money should go to publishing costs” sentiment. Journals have costs, but why not have institutions cover costs if you bring a paper over the line. Up to a limit of course.
Let me put my @mbeisen hat on for a second …. We can avoid all of this and a lot more by completely getting rid of journals. They are a massive obstacle to scientific progress - the @NIH should refuse to allow ANY of its money to be spent on journals.
For readers interested in GPCR drug discovery, here's a perspective on pharmacological characterization of GPCR modulators rdcu.be/esWfS and a review on functional dynamics studies revealing new approaches rdcu.be/esWgt
GRK-biased adrenergic agonists for the treatment of type 2 diabetes and obesity: Cell cell.com/cell/fulltext/…
The NSF’s proposed FY26 budget request includes a staggering 50% reduction in funding. It’s alarming that leaders can’t- or won’t -grasp the long-term damage this will do to our research, innovation, and the future of America’s scientific workforce.
Well this is new (and welcome): just reviewed a paper for a @PLOSBiology and my review was not anonymous (I signed the review as is an option). It would be wonderful if all journals allowed this option.
🧬 Excited to share our new @Nature paper on allosteric modulation at FFA2! Multidisciplinary collaboration with Cheng Zhang @PittTweet and @ProfGMilligan reveals new mechanisms for designing safer metabolic therapeutics. @BBSRC @pharmacyatQUB nature.com/articles/s4158…
To say something obvious out loud with regards to science trainees: ChatGPT is a great tool, but it won't be there for you in thesis defense, or in job interview
It’s a hefty 206-page research paper, and the findings are concerning. "LLM users consistently underperformed at neural, linguistic, and behavioral levels" This study finds LLM dependence weakens the writer’s own neural and linguistic fingerprints. 🤔🤔 Relying only on EEG,…
New preprint from @DuXDaniel @FitzpatrickLab shows #femtosecond light pulses can lens electron beams, promising higher contrast in #cryoET and better aberration correction in #cryoEM biorxiv.org/content/10.110… Experiments made possible by support from @cziscience #ImagingTheFuture
It should be an absolute requirement of all @NIH grants that all journals reviews - including/especially when they lead to rejection - should be made publicly available.
From today, all new submissions to Nature that are published will be accompanied by referees’ reports and author responses — to illuminate the process of producing rigorous science go.nature.com/44hKo29
The world is in chaos, but we still need to rally with our people. Janetzko-Bell lab and friends happy hour to celebrate some grant submissions, new additions and accomplishments 🎉 @CU_BMG @CUCardiology @CUDeptMedicine
We can unequivocally oppose attacks on science and all that they stand for, and still talk honestly about what we can do better to maximize the value of science to society.
Another great collab with @jjanetzko, @rvshivand, Jonathan, the Kobilka lab and @GreenstoneBio, stay allosterically tuned… biorxiv.org/content/10.110…
Setting up a lab has been no joke. Today, I'm stoked to have one more piece of my postdoc work out in the wild. Several more manuscripts to go, and I don't have a lot of time for a tweetorial today, but enjoy and happy to get any feedback on this story. biorxiv.org/content/10.110…