Dirk H. Siepe

@TheCoxLab and @Coon_Labs scientists succeeded in developing a new method to generate a more detailed #proteome than ever before, providing insights into how #GeneticVariants and #SpliceVariants in humans impact the proteome. Published in @NatureBiotech nature.com/articles/s4158…

AlphaBind paper is out. Trains on 7.5M Ab‑Ag reads + protein LMs to build a 15M engine for rapid affinity boosts🚀 Single round delivers up to 74× tighter binding from just 3‑11 edits, yielding thousands of diverse, developable variants🧬#AntibodyAI #bioAI

I am happy to share that we have a great opportunity for a postdoctoral scientist. Please share. hhmi.wd1.myworkdayjobs.com/en-US/External…

Another great collab with @jjanetzko, @rvshivand, Jonathan, the Kobilka lab and @GreenstoneBio, stay allosterically tuned… biorxiv.org/content/10.110…

Setting up a lab has been no joke. Today, I'm stoked to have one more piece of my postdoc work out in the wild. Several more manuscripts to go, and I don't have a lot of time for a tweetorial today, but enjoy and happy to get any feedback on this story. biorxiv.org/content/10.110…

Structural Diversity of Metabotropic Glutamate Receptor/Beta-Arrestin Coupling biorxiv.org/content/10.110… #biorxiv_biophys

…high jacking the UPS, great read featuring bifunctional and multifunctional degraders: sciencedirect.com/science/articl…

Induced proximity at the cell surface - @CarolynBertozzi go.nature.com/4c9hu6M

Excited and proud to have this paper published with @NatureComms today! Great project led by @DrJuanLMendoza at @UChicagoPME and @HHMINEWS. Excited for the future of the field - stay tuned for a full breakdown and walkthrough of our results! nature.com/articles/s4146…

Just before the New Year: BindCraft v1.5! Please fill out this form to request new features and help us make BindCraft even better. forms.gle/XsGHDCyHtczVba…

😀Excited to share our new findings in @CellCellPress! cell.com/cell/fulltext/… Dynamic allostery drives autocrine and paracrine TGF-ß signaling #TGFbeta #DynamicAllostery #CryoEM #StructuralBiology #MedicalInnovation

Such a amazing story, congrats to @vcluca1 and the whole team

What if you could design binders to specific spots/motifs on target proteins: conserved epitopes on pandemic viral phosphoproteins, disordered regions on dysregulated transcription factors, or even breakpoints on fusion oncoproteins? That would unlock unprecedented specificity…

Today we remember and celebrate the life of Bill Weis. Our friend, colleague, & mentor. We scientists are lifelong learners by temperament & necessity. Bill fueled our learning daily. 1/n

Excited to the see the diversity of and emerging successes for extracellular protein degradation (eTPD) to pair with the established successes of intracellular protein degradation (iTPD). @Kaan_Kumru_ and I are thrilled to share this review! ...no protein is safe!

Extracellular targeted protein degradation: an emerging modality for drug discovery bit.ly/489BXVZ This new review by @realJimWells & @Kaan_Kumru_ covers systems for extracellular targeted protein degradation, including LYTACs, ATACs, AbTACs, PROTABs and KineTACs

Want to hunt down the cullin-RING E3 #ubiquitin ligases involved in your favorite pathway or #DegraderDrug? Exited that our story on probing active (neddylated) #CRL E3 complexes using conformation specific probes is out now! nature.com/articles/s4158…

Congrats to Alex on his Notch paper published in Science Signaling! Special thanks to our fantastic team - Emily, Lena, Drew, Julia and collaborators. Click here to read the paper. science.org/doi/10.1126/sc…

The Human Cell-Surface Interactome Project, deposited by Chris Garcia's lab, is now available hubs.la/Q01Jg1-S0

Excited to share the latest work from my time in the Garcia Lab: Receptor Elimination by E3 Ubiquitin Ligase Recruitment (REULR), a Nanobody based, modular mix & match Targeted Protein Degradation (TPD) toolbox to target cell surface receptors. @ACSSynBio pubs.acs.org/doi/10.1021/ac…