Gene Regulation

Excited to share our latest study published in Nucleic Acids Research: academic.oup.com/nar/article/53… It’s the cover story for Issue #12! We drew inspiration from Greek mythology to illustrate CTCF’s constant struggle in shaping the 3D genome architecture.

Our new paper is finally out, showing that the same enhancer sequences - and likely the same transcription factors recruited to them - affect the activity of distal enhancers and their looping over to target gene promoters. nature.com/articles/s4146…

@sara_mostafavi (@genentech ) & I (@Stanford) r excited to announce co-advised postdoc positions for candidates with deep expertise in ML for bio (especially sequence to function models, causal perturbational models & single cell models). See details below. Pls RT 1/

Perspective on recent developments and challenges in regulatory and systems genomics academic.oup.com/bioinformatics… is out, amazing to think about this with @JuliaZeitlinger, @ferhatay, @mahonylab, @AMathelier, @AleMedinaRivera, @jernst98!

We have a postdoctoral opening for a researcher with experience in bioinformatics of DNA sequencing and machine learning to work on the development of new methods for cancer diagnostics related to nucleosomes, chromatin and more jobs.ac.uk/job/DMK060/sen…. Apply by 21st April 2025!

I am so happy to see this work finally out 🎉 authors.elsevier.com/c/1kqIJ_Oylrlz… Thanks to all the authors for the incredible teamwork!!!

❤️‍🔥 Passionate about gene regulation research, wet/dry lab? 🎡 Excited about London's vibrant research and social scene? 🔬 Looking for a funded postdoc position (+ ideally, have the CV & drive to apply for a fellowship in your 1st year)? Please DM/email me to discuss!

My first, first author paper is now on bioRxiv! 🤩 Linker histone H1 is a liquid-like "glue" condensing chromatin, which revises textbooks! 📖✨ biorxiv.org/content/10.110… Huge thanks to my PI, @kazu_maeshima, for supervision. Amazing collab with @rcollepardo’s group!" (1/n)

🚨 Registration for the Molecular Biosystems Conference is now OPEN! Join us to discuss cutting-edge research in gene regulation & functional genomics. 📅 Sep 29-Oct 3, 2025 📍 Puerto Varas, Chile 🔗 Register here: molbiosystems.com Register now—space is limited!

Very happy to contribute to this paper about cfDNA in SCLC, led by the team of Anish Thomas. It's already online in Genome Medicine: Takahashi et al., Genomic alterations and transcriptional phenotypes in circulating free DNA and matched metastatic tumor genomemedicine.biomedcentral.com/articles/10.11…

Our latest preprint on emergent #3Dgenome reorganization from the stepwise assembly of the #transcriptional #condensates. Check it out! #GeneExpression #chromatin @generegulation @Pha_Tran_Papers @4DNucleome #cellularstress tinyurl.com/3sdsdrd6

New paper alert! The epigenetic landscape shapes smoking-induced mutagenesis by modulating DNA damage susceptibility and DNA repair efficiency academic.oup.com/nar/article/53….

We are looking to recruit a highly motivated postdoc with cell or molecular biology expertise. Excellent #epigenetics, #chromatin training & networking opportunities @qmulepigenetics DM me for inquiries pl apply/share tinyurl.com/m6jnksk5

IT'S HAPPENING! The Woodstock of Biology 2.0 meets Night Science @nightsciencepod 10-13 of June in Prague & the Woods of Bohemia... Be there or be REJECTED. #theconferencetoendallconferences

Our new study shows in our that the fate of foreign DNA in a eukaryote depends on its GC content. It can either packaged into active or inactive chromatin. science.org/doi/10.1126/sc…

Shifting the pitch and contours of Waddington’s valleys, putative enhancers, and transcription through H3K27me3 chromatin in the endoderm. Find it all here: journals.plos.org/plosgenetics/a…. Fantastic collaboration with @josh_brickman and @wendy_bickmore. Well done Jurriaan and @djmbio.

Happy to contribute to this excellent story about heterochromatin role in centromere maintenance, led by @ben_carty93 ! Heterochrom. boundaries control centromere expansion, drift & number! Great usage of induced neocentromere model and modern epigenomics across the labs🥳

CPGE's most recent publication on cohesin function and chromatin domain organization is out now in Science Advances. This thread will take a look at some of the key observations from the paper! #chromatin #epigenetics #genomics #northwestern #dna science.org/doi/10.1126/sc…

Transcription ahead of chromatin regulation? Activation in endoderm occurs prior to K27me3 removal, plus much more. A tribute to our collaborations with @wendy_bickmore and @RobertIllingwo7, who worked tirelessly to insure this data saw daylight!journals.plos.org/plosgenetics/a…

1/ I am beyond thrilled to share our new paper in @CellCellPress! We explored the regulatory principles underlying pleiotropy in psychiatric disorders. cell.com/cell/abstract/…