Teif Lab

My first interview in a major podcast :) Quite an interesting experience! Thank you very much for inviting @epigenetics_pod

Very happy to contribute to this CTCF-nucleosome paper by @ElenaPugachev12 &Co. Exciting science and a cool journal cover!

Excited to share our latest study published in Nucleic Acids Research: academic.oup.com/nar/article/53… It’s the cover story for Issue #12! We drew inspiration from Greek mythology to illustrate CTCF’s constant struggle in shaping the 3D genome architecture.

Happy New Year! 2024 was not easy, but despite many challenges we also achieved a lot. We've got grants, published papers, have new exciting findings. This would not be possible without support of friends and collaborators. Wishing you health, happiness, peace & success in 2025!

Thank you very much @PancreaticCanUK for supporting our research! In collaboration with Andrea Mohr, Ralf Zwacka and Greg Brooke, we are developing a new generation of liquid biopsies for early cancer detection based on the analysis of cell-free DNA 🧬

NHS announced that it will start offering first liquid biopsy tests for diagnostics of lung and breast cancer; also planning expansion to pancreatic and gallbladder cancers england.nhs.uk/2025/05/nhs-fi…

We have a postdoctoral opening for a researcher with experience in bioinformatics of DNA sequencing and machine learning to work on the development of new methods for cancer diagnostics related to nucleosomes, chromatin and more jobs.ac.uk/job/DMK060/sen…. Apply by 21st April 2025!

Very happy to contribute to this paper about cfDNA in SCLC, led by the team of Anish Thomas. It's already online in Genome Medicine: Takahashi et al., Genomic alterations and transcriptional phenotypes in circulating free DNA and matched metastatic tumor genomemedicine.biomedcentral.com/articles/10.11…

Early detection of #PancreaticCancer saves lives. @TeifLab @EssexLifeSci are using cutting-edge technology to measure fragments of tumour DNA in the blood. This "liquid biopsy" could provide an accurate & affordable new test for pancreatic cancer: bit.ly/3F3vXF1

2nd time at #FOG2025 (1st time presenting!), it never disappoints!✨ Great talks, groundbreaking research and good times with old&new friends Huge thanks to everyone who stopped by my poster, truly grateful for the interest & discussions Already looking forward to next year!🙌

So excited for the festival and this great opportunity to present my research 😄

Low quality picture but… Had to show the matching glasses 🤭🤓

Interesting preprint on nucleosome spacing from cfDNA [Johnston et al., 2024] biorxiv.org/content/10.110…. The authors refer to NRL changes 10n -> 10n-5 bp. Earlier we showed that NRL decrease in cancer is more complex & context-specific [Jacob et al., 2024] link.springer.com/article/10.118…

Hope to see some of you in Hong Kong next year! Circulating Nucleic Acids in Plasma and Serum, 14th CNAPS International Symposium. Hong Kong, December 3-5, 2025. cnaps2025.org. #SNAPS2025 #cfDNA #liquidbiopsy

some statistics about mass migration of scientists, specifically for our field: ▶️~30% of our followers created accounts on bluesky (most of them stay on both platforms) ▶️~0.8% of our followers deleted accounts on X ▶️likely there will be sizable fractions on both platforms

Dear friends, please reply if you know a neurosurgeon in Romania (or close contacts among medical doctors in Romania who may connect with neurosurgeons). This is for a medical emergency, not for academic research.

📢 The 2025 Biophysical Society Annual Meeting in LA is around the corner, and we need nominations/self-nominations for 5 leadership positions for the Multiscale Genome Organization Subgroup This is a fantastic opportunity to support our field and engage with the Society. 🧵⬇️

This idea is very interesting, but did anyone try to check such hypotheses (re: HP1a) with nucleosome maps? More generally, looking for publications where NRL changes are shown for local regions enriched with certain proteins (excluding studies regarding gene bodies & TF binding)