Josh Brickman
@josh_brickman
Developmental and Stem Cell Biologist, Interested in the transcription, lineage specification, potency and plasticity. @josh-brickman.bsky.social
How does metabolism act through generic chromatin modifiers promote specific cellular states? Simultaneous modification of transcription factors and chromatin, enhancing epigenetic signal to noise ratios. embopress.org/doi/full/10.10…
Electric fields guide collective cell migration in developing embryos of Xenopus laevis via a voltage-sensitive phosphatase. @Mech_Morph_Lab nature.com/articles/s4156…
Happy to share our new review!
To launch the collection, our review "The regulation and function of post-transcriptional RNA splicing" by Karine Choquet, @inespatop & Stirling Churchman @fiddle (go.nature.com/4kylbWL) will be free for 1 month
Here is a great joke. Thursday May 22nd , 1pm . Lab meeting. A scientists gives a 30 minute pep talk that boils down to “ guys I know things are bad, we had to let some people go, our grands are terminated , our awards are denied. BUT the great news is this is AS BAD as it gets !…
The latest piece of @mproksik PhD, for step in our nf-core saga, and a new MARS-seq pipeline. Check it out at academic.oup.com/bioinformatics…
Very happy that the work of @Alboo recognized in this collection. It was an amazing PhD and her paper included here - cell.com/stem-cell-repo… - only a part of it....
The Stem Cell Reports Best Of 2024-2025 issue is out now! Read the full issue to explore the most notable papers published over the last year. ow.ly/8ZaZ50VWsCa @ISSCR @CellPressNews @GairdnerAwards @SickKidsNews
Incredible achievement for old school developmental biology interfacing with the translational world! Congratulations to Melissa - very well deserved!
reNEW CEO named Fellow of the Royal Society Professor Melissa H. Little, reNEW’s CEO, has been appointed Fellow of the Royal Society. Fellows of the Royal Society are many of the world's most eminent scientists, engineers and technologists. Founded in 1660 and based in London,…
Metabolism driving the exit from pluripotency into mature trophoblast - beautiful work from my colleague @JZylicz
Can metabolism regulate more than bioenergetics during human development? Our new study says YES! We show that metabolism influences cell fate choice in human naïve pluripotent stem cells, histone acetylation, and trophectoderm maturation. rb.gy/spqr9j @NatureCellBio
Shifting the pitch and contours of Waddington’s valleys, putative enhancers, and transcription through H3K27me3 chromatin in the endoderm. Find it all here: journals.plos.org/plosgenetics/a…. Fantastic collaboration with @josh_brickman and @wendy_bickmore. Well done Jurriaan and @djmbio.
Why thank you Katie!
H3K27me3 supports endodermal differentiation "PRC factors both restrain exit from the desired trajectory by canalizing gene expression programmes and control the incline upon which a cell tracks towards a new state." Nice work! @josh_brickman @RobertIllingwo7 @wendy_bickmore
In the next few weeks we will start advertising for PhD students and/or post docs. We are looking for two people to join our group, one focused in pancreatic organoids and the other to join our computational team. DM if you are interested!