Elena Pugacheva
@ElenaPugachev12
Researcher, Optimist
👁️ Systematic identification of interchromosomal interaction networks supports the existence of specialized RNA factories Borislav Hristov, William Stafford Noble & Alessandro Bertero | Genome Res (Sep 25, 2024) genome.cshlp.org/content/early/…
⚠︎ CTCFLike BORIS CTA epigenetically reprograms transcriptionally inert clustered CTCF binding sites into alternative promoters driving expression of both coding and non-coding genes Genome Biology (Jan 31, 2024) doi.org/10.1186/s13059… genomebiology.biomedcentral.com/articles/10.11…
Check out the latest from Michele on the disease named after him (YY1 mutations --> Gabriele-de Vries syndrome). Michele is on the job market - do not miss out :) K99: reporter.nih.gov/search/832CJGw… Paper: science.org/doi/full/10.11…
Proud to share the first neuronal model of the disease we discovered in 2017! Here we describe that #YY1 mutations affect corticogenesis in a cell-type specific fashion, and in #organoids, we observed a phenotype that recapitulates clinical features!
Happy to share! Our latest publication in Genome Biology unveils how BORIS/CTCFL epigenetically reprograms transcriptionally inactive intronic CTCF sites into alternative promoters: genomebiology.biomedcentral.com/articles/10.11…
#sciencetwitter #ScienceJobs #postdocposition #postdoc #Fellowship #JobAlert #jobsearch #researchers #Ukrainereturnstudents #PhDposition #university #training #Learn4Life help my Lab @boris_ctcf to find a new postdoc according to the Job Ad @ training.nih.gov/postdoc_jobs_n… copied below:
We are looking for a new bio-computational PhD Fellow capable to analyze at least some of many diverse "omics" NG-Seq datasets obtained with genome-edited mouse strains & human cell lines designed to study a unique type of site-specific epigenetic marks: training.nih.gov/postdoc_jobs_n…
We are looking for a new bio-computational PhD Fellow capable to analyze at least some of many diverse "omics" NG-Seq datasets obtained with genome-edited mouse strains & human cell lines designed to study a unique type of site-specific epigenetic marks: training.nih.gov/postdoc_jobs_n…
Thank you for pointing out this, it's an excellent paper! It seems indeed the effect of CTCF mutation is bigger than the effect of CTCF acute depletion, and the latter one is time-dependent.
The fact that the loop is not immediately disturbed after CTCF/Cohesin depletion makes total sense, because chromatin is not at a thermodynamic equilibrium. Significant time is needed to "relax" an existing chromatin loop, even if loop ends are no longer forced to stay together
Hulk, I'm a big fan. But to be clear, we do not say that CTCF/Cohesin do not regulate E-P, 3D folding, or gene expression. Just that they are not required for short term maintenance (3 hr) for most genes/loci. Please see line numbers 498-523 in the PDF biorxiv.org/content/10.110…