Carlos R. Escalante
@crescalantelab
Escalante Group at VCU School of Medicine, X-ray Crystallography, Cryo-EM, SAXS, AUC, AAV, Transcription Factors. All opinions, my own.
Jeremy M. Berg: Life-saving medicines begin in the basic research DOGE wants to stop funding post-gazette.com/opinion/guest-… via @PittsburghPG
Exclusive: NIH to dismiss dozens of grant reviewers to align with Trump priorities nature.com/articles/d4158…
It's a sad day for many young scientists around the country. NIH just sent termination notices for MARC, GRISE, PREP, IMSD, IRACDA, and BRIGES.
Scientists are increasingly turning to AI to tackle problems related to scale and complexity - from synthesizing the evidence base to simulating experiments. Our new essay draws on expert insights and interviews to examine the opportunities, risks and policy implications. →…
1/ Very excited to present cryoSTAR, a novel approach for continuous heterogeneity in SPA cryo-EM. In brief, cryoSTAR leverages the prior knowledge from a user-given atomic model to better find dynamics in the final reconstruction. bytedance.github.io/cryostar/ biorxiv.org/content/10.110…
Train PhD students to be thinkers not just specialists #PhD #PhDlife #academics #AcademicChatter #AcademicTwitter #Postdocs #Research #Science
Happy to share the latest preprint from our Lab. The Cryo-EM structure of AAV-2 Rep68-AAVS1 complex. COngratulations to Rahul and all the team. doi: doi.org/10.1101/2024.0…
Congratulations to the Aggarwal lab.
rdcu.be/dxXUG Just published from the Aggarwal Lab in @NatureSMB! Congrats to my labmates! 👏 Great work on the bacterial antiphage #CBASS system’s Cap5 endonuclease activation. @jitheshkottur 🎉 #bacteria #phage #nsmb
Happy to share the publication of our paper in @Nature Conformational ensembles of the human intrinsically disordered proteome Work led by @GiulioTesei and @AnnaIdaTrolle. I'll post more later, but for now here is a link: nature.com/articles/s4158… and a short movie about the work
Looking Forward to what's ahead. Understanding the cell: Future views of structural biology: Cell cell.com/cell/fulltext/…
"We are standing on the cusp of a new era of biology, where the integration of multimodal structural datasets with multiscale physics-based simulation will enable the development of visible, virtual cells." cell.com/cell/fulltext/… @bengeliscious @biozentrum @svenklumpe @EM_STP
Here's our new research in @ScienceAdvances by @LANEVOL postdoc @rorylcooper & Michel! We reveal that transient sonic hedgehog agonism triggers a permanent scale-to-feather transition on the chicken footpad🔬🐣 science.org/doi/10.1126/sc… @genevunige @sciences_UNIGE @UNIGEnews
For many years, the one of the best if not the best book about how science is make and the human side of the people who make it. A must have in any personal library.
I’m super excited to dive into this 1979 classic on the early history of molecular biology. Thanks to CSH Press for releasing a commemorative edition in 2011! @cshperspectives
Good to know, next time I have a long layover at Newark, I now know where to wait!
Who’s in charge of the playlist here at Newark Airport (@EWRairport) Terminal C? Over the last several months, I’ve heard everything from Andrew Hill to @Joshua_Redman to @bmarsalis and now they’re blasting ESP. This is how you get the morning started! (Now I hear Stanley…
This is a horrible story worth reading. science.org/content/articl…
🧵of the year! A real eye opener - If there’s just one article you read this year, make it this! @PhilippMarkolin lays out how social media is so good at manipulating us. It’s not just the algorithms promoting negative narratives, it’s armies of malcontents like these folks…
NEW EXCLUSIVE from me: #Denounce, #deny, #deceive - 6 common tactics of media manipulators and why they work to sabotage public discourse Read: protagonistfuture.substack.com/p/denounce-den…
“From the Buddhist perspective, life and death are two phases of a continuum. Life does not begin at birth nor end at death. Everything in the universe—from invisible microbes in the air we breathe to great swirling galaxies—passes through these phases. Our individual lives are…
Great work, congrats
Resolving the AAA+ ATPase Puzzle in Slow Motion. Cutting-edge cryoEM, time-resolved studies and slower burning fuels. Big thanks to the heroes of the M-team; esp. @JirkaWald @DirkFahrenkamp. Enjoy! (marlovitslab.org)
Origin of life theory involving RNA–protein hybrid gets new support nature.com/articles/d4158…
