Richard Quintana Feliciano, PhD

nature.com/articles/s4146… Our paper is out in Nat. Commun.! 🎉 An amazing collab between the Aggarwal, Fang, Filizola, and Shapiro labs. We show a mechanism of #DNAbinding wherein each monomer of M.BceJIV #methyltransferase helps to recognize two #DNAs! #epigenetics #methylation

So excited to have my first project in the @DrChristineAnnD lab finally online! doi.org/10.1101/2024.0…! Tl;dr: we made an R software package for scalable mapping and (most importantly) analysis and visualization of 𝘮𝘶𝘭𝘵𝘪𝘱𝘭𝘦 brain-wide ensembles.

First Reaction with colleague @WackerLab "Can Targeting the Sodium Site via Water Molecules Lead to the Development of Safer Opioids?" @sushmajumdarlab , we hope you'll enjoy reading our opinion | ACS Central Science pubs.acs.org/doi/10.1021/ac…

Amazing work by Dr. Rechkoblit et al. from the Aggarwal and @gangfang_1 Labs on CBASS Cap5 endonuclease showing bacterial self-destruction by digesting its own DNA! Congratulations! 👏 #bacteria #cbass #cap5 #proteinstructure #immunology #virology nature.com/articles/s4146…

Would you like to discover low-efficacy ligands or biased ligands for GPCRs? Our fine-tuned deep learning models using transfer learning and protein language processing make it possible! | bioRxiv biorxiv.org/content/10.110…

Glad to share our preprint 🏃**LongTrack**: long read metagenomics-based precise tracking of bacterial strains (and their genomic changes!) after fecal microbiota transplantation. A 4+ years journey and tour de force by ** @fanyu48696214 ** and team. A long 🧵 💩Fecal microbiota…

We are proud to partner with @IcahnMountSinai to offer a joint Ph.D. program in health sciences engineering. Beginning in the fall semester of 2025, the program will focus on reparative and regenerative medicine, immunoengineering, and neuroengineering. bit.ly/3CD2mB3

Check out this amazing resource! High quality illustrations for free! bioart.niaid.nih.gov HT @LuciaScience

Paper of the week: Our new @PsychopharmEBPS paper, led by Jennifer Bossert, on the effect of nociceptin receptor partial agonist & antagonist on heroin relapse in our rat model of opioid maintenance. Neither drug mimicked buprenorphine effect in the model pubmed.ncbi.nlm.nih.gov/39269500/

Paper of the week: Our collaborative study with Yihong Yang's imaging lab, published in @npp_journal (first author: Zilu Ma), on the role of the dorsal striatum in incubation of opioid craving after voluntary abstinence in rats pubmed.ncbi.nlm.nih.gov/39300270/

Very important read!

We are pleased to share a collaboration of the Aggarwal, Fang, @filizolalab1, and Shapiro Labs publication in @NatureComms! nature.com/articles/s4146…

Review of the week: excellent 2008 review on social stress and addiction to commemorate the career of Klaus Miczek, who died this week. Klaus published many exceptional papers on aggression, stress, and addiction, and his work has inspired many of us pubmed.ncbi.nlm.nih.gov/18789966/

🚨 NEW @npp_journal paper alert 🚨 Barbano, Morales, & team report that VTA glutamatergic projections to the nucleus accumbens suppress psychostimulant-seeking behavior in 🐭 nature.com/articles/s4138…

🚨 New preprint alert! 🚨 We explore the role of E2F3a in regulating cocaine reward at sex- and cell-specific levels in the nucleus accumbens. Read more on our findings below. Thanks to all co-authors and supporters for their contributions! 💎💎😊🙌

Today in @ScienceMagazine, we report how a bacteria has evolved into a major human pathogen over the last 200 years. Read on, this is going to be an adventurous ride 1/n! science.org/doi/10.1126/sc…

We are proud to announce the publication of a new study by @angelica_atb in @NeuroCellPress which characterizes a novel role for H3K27me1 as a "chromatin scar" in nucleus accumbens that contributes to long-lasting sequelae of chronic stress. @SinaiBrain sciencedirect.com/science/articl…

There were an insane number of "big" biotechnology papers published this week. The Bridge RNA gene-editing papers are important. But here are 7 more advances. Many new CRISPR tools, epigenetic editing for prion disease, gene drives for plants & more...🧵

What if we could universally recombine, insert, delete, or invert any two pieces of DNA? In back-to-back @Nature papers, we report the discovery of bridge RNAs and 3 atomic structures of the first natural RNA-guided recombinase - a new mechanism for programmable genome design

We have multiple openings in our lab (research scientist/manager/technicians). Postdoctoral positions soon, but emails or DMs are welcome. Please share 🤗 explore.jobs.ufl.edu/en-us/job/5319… explore.jobs.ufl.edu/en-us/job/5319… explore.jobs.ufl.edu/en-us/job/5319…