Tom Marlovits
@MarlovitsLab
Uncovers concepts of life. Curiosity driven.
Resolving the AAA+ ATPase Puzzle in Slow Motion. Cutting-edge cryoEM, time-resolved studies and slower burning fuels. Big thanks to the heroes of the M-team; esp. @JirkaWald @DirkFahrenkamp. Enjoy! (marlovitslab.org)
Delighted to be a recipient of one of these with a fantastic group of scientists - @edith_houben @MarlovitsLab and John McKinney. Look out for CombaT7!
📣 Results of the 2024 ERC Synergy Grant competition are out! 57 research groups won a total of €571 million in #ERCSyG funding, enabling them to pool diverse expertise & resources to push the frontiers of knowledge. 👉 europa.eu/!bmpNW9 🇪🇺#EUfunded #FrontierResearch
📣 Results of the 2024 ERC Synergy Grant competition are out! 57 research groups won a total of €571 million in #ERCSyG funding, enabling them to pool diverse expertise & resources to push the frontiers of knowledge. 👉 europa.eu/!bmpNW9 🇪🇺#EUfunded #FrontierResearch
Many thx to David Goodsell and the selection team for portraying this ingenious molecule.
Congratulations to the @MarlovitsLab! Their type 3 secretion system needle complex from Salmonella enterica is the Protein Data Bank @buildmodels molecule of the month. pdb101.rcsb.org/motm/294
#Darobactin ist ein vielversprechender Kandidat für ein neues #Antibiotikum gegen gramnegative Bakterien und verfügt über einen bisher ungenutzten Wirkmechanismus. Ein Team @Helmholtz_HIPS & @DZIF_ hat nun den Wirkstoff weiter verbessert. #AMR 📷HZI/Rohde helmholtz-hzi.de/de/aktuelles/n…
Hijacking eukaryotic cells through T3SS-mediated effectors. Unique binding pattern on actin filament stabilizes young F-actin under substoichometric conditions. Very clever strategy! science.org/doi/10.1126/sc…

How do neutralizing antibodies function? Employing CryoEM alongside samples obtained from CFTR patients who exhibit resistance to Pseudomonas infections. Cell (2023) doi.org/10.1016/j.cell…

Have fun! Great potential for on-the-fly processing.
The @MarlovitsLab and collaborators at @helmholtz_image/@desy developed PickYOLO, an ultrafast particle finder for cryo electron tomograms. @MileticSean @Rorydhj #cryoEM Find out more: t1p.de/1fr9o
Dancing T7! What a treat! Congrats now - discoveries to come. Stay tuned.
Super excited to have been awarded an @NWOFunding Veni grant to continue my research into mycobacterial T7SSs at @VUamsterdam , in collaboration with @CssbHamburg @MarlovitsLab . Special thanks to @edith_houben @wilbertbitter for their continuous support!
Fighting the silent pandemic: Unlocking the power of biology, biosynthesis, and structural biology (cryoEM).
The @MarlovitsLab together with collaborators from @Helmholtz_HIPS have engineered a new molecule with superior antibiotic activity called darobactin 22. Find out more: bit.ly/3xPoYZs
What a Christmas present! Visual sequencing ....

StarMap, a plugin to perform Rosetta refinement, is now available in ChimeraX! Get it from Tools/More Tools… and run cryoEM modelling in three easy steps: dock homology model, refine, analyze and enjoy the high-quality output. For more details see doi.org/10.1038/s41596…
Jiri Wald (@Jirkawald), IMBA/@IMPVienna alumnus from the @MarlovitsLab, won the @viennabiocenter PhD Award for work that worked to reveal the architecture, functional cycle, and mechanism of a molecular motor that interacts with DNA. 🎯 The Story. bit.ly/3DTequR @oeaw
#NewNProt: #StarMap refines protein #molecularmodels into experimental density maps using robust Rosetta workflows go.nature.com/3NMOk0W @MarlovitsLab
StarMap is now available in ChimeraX's toolshed (v1.4) cxtoolshed.rbvi.ucsf.edu/apps/chimeraxs…
Need to refine a molecular structure or an entire molecular machine? A few clicks in "StarMap"within ChimeraX will do this automatically. Analytical outputs help checking results also manually. (marlovitslab.org) nature.com/articles/s4159…
Congrats to all awardees! Spectacular research!
🏆 We are thrilled to announce the award recipients of this year’s @VBCPhdSymposium. And the winners are… 🥁 (1/5)
Really nice story! Congratulations!
OUT NOW 👉Methanotrophy by a Mycobacterium species that dominates a cave microbial ecosystem @wilbertbitter @Ch_Melkonian @CatalinBunduc @pathogensKAUST1 @niooknaw nature.com/articles/s4156…
Read the story behind "StarMap": How to solve a molecular tangram protocolsmethods.springernature.com/posts/how-to-s…
Need to refine a molecular structure or an entire molecular machine? A few clicks in "StarMap"within ChimeraX will do this automatically. Analytical outputs help checking results also manually. (marlovitslab.org) nature.com/articles/s4159…
Need to refine a molecular structure or an entire molecular machine? A few clicks in "StarMap"within ChimeraX will do this automatically. Analytical outputs help checking results also manually. (marlovitslab.org) nature.com/articles/s4159…
