clarice
@claricehongky
Postdoc @hansen_lab | Former grad student @BarakACohen lab | Gene regulation ❤️ | 🇸🇬
Proud of my amazing friend for his super cool work ♥️
1/ Super excited to share my first preprint from @hansen_lab! We used MINFLUX to track chromatin (H2B-Halo and Fbn2 locus) at an unprecedented 200 μs, then combined it with SPT to span μs-minutes (H2B) or SPT & Super-Res Live-Cell Imaging (SRLCI) to span μs-hours (Fbn2)
Excited to share my first preprint from @hansen_lab! It's got genomics, AI, and biology - all wrapped up in a great paper. Also very grateful to my amazing collaborator, Fan, for all his hard work. Please check it out and let me know what you think! tinyurl.com/bdfvtd6f
Why do different variants in the same gene cause different forms of disease? In our latest preprint we use MPRA technology to test how two blindness-causing variants alter the function of CRX in mouse models. Work of our collaboration with @Chen7Shiming. biorxiv.org/content/10.110…
Super excited for the next phase of my training and to be part of this amazing group! 😊
We are thrilled to welcome Clarice @claricehongky to the lab as a new post-doc. Clarice recently finished her the @BarakACohen lab at WashU. Welcome Clarice!
Our single-cell MPRA paper is finally out! Super excited about the potential of this technology to study cell-type specific gene regulation 🥰
Out today in @NatureGenet, our group’s single-cell MPRA technology for testing activities of gene regulatory elements in whole tissues. Congrats to Siqi Zhao and the rest of the crew for their great work! nature.com/articles/s4158…
This is a really nice summary of the recent papers on E-P compatibility: doi.org/10.1016/j.molc…. Also nice to see that their results support our model that interactions between CREs are strength-dependent rather than dependent on specific TFs! (from genome.cshlp.org/content/32/1/85)
Our paper on insulators is out on Biorxiv! We tested the activity of insulators across thousands of genomic locations to figure out where insulators function. Oh, and I successfully defended today :) biorxiv.org/content/10.110…
We have a new version of this preprint! There are 2 key changes - we now show that scMPRA works in mouse retina (!), and we finally implemented the second U6 transcript to detect unexpressed promoters. Siqi worked really hard on this so please check it out 🙂
Check out the latest preprint from our lab by my dear friend Siqi :) He developed a method to perform MPRAs in single cells and show that it can be used to detect cell-type specific regulation and cell-to-cell variability in cis-regulatory elements! biorxiv.org/content/10.110…
Our paper is now out in @genomeresearch! Extremely grateful to @BarakACohen and all the people who made this possible. Happy to talk to anyone who has questions or just want to discuss the paper :) genome.cshlp.org/content/early/…
My first preprint ever is up! 😄 We show that the strength of core promoters, not it's identity (or class, or motifs) determine how it responds to its surrounding genomic environment. biorxiv.org/content/10.110…
Ever wondered what could go awry when your body copies a 6 billion letter message (i.e. your #genome) 1E16 times over your lifetime? If so, checkout our #preprint on the origins and functional effects of #mutations throughout the human lifespan. bit.ly/3yT5KBz
Check out the latest preprint from our lab by my dear friend Siqi :) He developed a method to perform MPRAs in single cells and show that it can be used to detect cell-type specific regulation and cell-to-cell variability in cis-regulatory elements! biorxiv.org/content/10.110…
Being part of preLights has been and continues to be awesome😊
Preprints by #preLighters 📰👩🏻🔬 We asked @claricehongky from the lab of @BarakACohen about her recent work and why they shared the study on bioRxiv prelights.biologists.com/news/27705-2/
How do human promoters sense genomic context to control gene expression? Exciting study from @BarakACohen integrating hundreds of promoters into different loci Promoters are broadly compatible with activation in different contexts biorxiv.org/content/10.110…
My first preprint ever is up! 😄 We show that the strength of core promoters, not it's identity (or class, or motifs) determine how it responds to its surrounding genomic environment. biorxiv.org/content/10.110…
I’m excited to share that our #CPTAC #proteogenomic adult glioblastoma study is out 🎉authors.elsevier.com/c/1cZZ05TA51Vx… What a great experience working with amazing researchers from @WUSTLmed @GenomeInstitute @PNNLab @theNCI and many others!!
How about extending the stimulus payments to non-resident aliens because, yknow, we lived here and paid taxes like everyone else??