ASHansen Lab
@hansen_lab
We seek to understand the molecular mechanisms that regulate genome organization and gene expression in time and space. Based in @MITdeptofBE
Mostly on BlåSky but excited to share James Jusuf's preprint: By integrating Micro-C with SuperRes Live-Imaging we perform absolute quantification of looping (e.g. this loop is present 3%). We quantify mESC 36k loops: <loops> are generally rare (2.3%). biorxiv.org/content/10.110…
Our preprint by @DomenicNarducci and the companion preprint by @deWitLab are now out in @MolecularCell ZNF143 is not a general looping factor and was identified as such due to a non-specific antibody. Instead it is TF with the longest residence time measured (to our knowledge)
(1/14) Excited to share our new work on ZNF143/ZFP143 by @DomenicNarducci ZNF143 has been widely reported to be a general loop factor Instead we and @deWitLab in a companion preprint show that ZNF143 is a TF with no loop function: biorxiv.org/content/10.110… biorxiv.org/content/10.110…
Come and see James' BATS talk today
First BATS of the academic year 2024/25 🥳! James Jusuf (@hansen_lab): “Genome-Wide Absolute Quantification of Chromatin Looping” ow.ly/Coyb50ThrOE
Congrats to @ngaboreden @blobelgroup with RCMC contribution from @ViraatGoel @hansen_lab . Having recently worked on what we thought was a looping factor (ZNF143 biorxiv.org/content/10.110… ) it was amazing to work on a strong Enh-Promoter looping factor LDB1 biorxiv.org/content/10.110…
Happy to share my thesis work, now online at bioRxiv. We show that LDB1 organizes Enhancer-Promoter interaction networks and can function independently of cohesin! biorxiv.org/content/10.110…
We are thrilled to welcome Coco Wu to the lab as a new graduate student from the @MITBiology graduate program co-advised with @fjsanchezrivera - Coco is interested in exploring the relationship between DNA sequence, DNA looping, gene expression, and disease!
Excited to welcome Jack Toppen to the lab as a new graduate student who joins us from the @MITCSBPhD graduate program - Jack is interested in developing computational tools for understanding and modeling transcriptional bursting.
Congratulations to Dr. Viraat Goel and Dr. Domenic Narducci, both new PhDs in Biological Engineering from the lab!
(1/13) Thread on @mazzocca_matteo @DomenicNarducci @SGrosseHolz @_jessematthias new preprint Q: how does chromatin move? Using MINFLUX, SPT & SRLCI, we track chromatin dynamics across 7 orders of magnitude in time to provide some answers biorxiv.org/content/10.110…
(1/n) New preprint from @claricehongky Fan Fang @VarshiniRam23 in collab w Jie Liu Q: How do we get ultra-high-res 3D genome maps? A: New deep learning model, Cleopatra. Cleo trains on Micro-C, fine-tunes on RCMC, and predicts genome-wide 3D maps biorxiv.org/content/10.110…
Excited to share my first preprint from @hansen_lab! It's got genomics, AI, and biology - all wrapped up in a great paper. Also very grateful to my amazing collaborator, Fan, for all his hard work. Please check it out and let me know what you think! tinyurl.com/bdfvtd6f
Check out Masahiro Nagano's preview sciencedirect.com/science/articl… of a very cool paper from Tjalsma...Wouter de Laat: cell.com/cell-genomics/…
Distance matters: How protein regulators facilitate enhancer-promoter interactions and transcription dlvr.it/TJWy4b
Very grateful to @NIH_CommonFund for funding our Transformative Research Award #NIHHighRisk
#NIHHighRisk Transformative Award recipient Dr. Anders Hansen of @MITdeptofBE will be exploring how transcription factors find their target cites in synthetic and #CancerBiology
Congrats to @ViraatGoel James Jusuf et al. on new preprint in collab with @Irate_Physicist @blobelgroup @leonidmirny discovering transient microcompartments that connect enhancers and promoters in mitotic chromosomes: biorxiv.org/content/10.110…
(1/n) From @ViraatGoel @Irate_Physicist et al. collab w @blobelgroup @leonidmirny biorxiv.org/content/10.110… RCMC at the M-to-G1 transition reveals strong microcompartments between CREs (E,P) in mitosis, that weaken upon G1 entry Sims reveal chromosome compaction as key regulator
Congrats to @GavinSchlissel @Pulin_Li with single-molecule imaging contribution from @DomenicNarducci @hansen_lab Single-molecule imaging of hedgehog in morphogen gradients reveals a surprisingly complex diffusion mechanism: pnas.org/doi/10.1073/pn…
Bittersweet to say goodbye to Christos last week - Thanks for 2 fantastic years and all the best for grad school at Columbia!
Congrats to Ava @AvaConyer on a fantastic MSRP poster presentation on the polycomb work she did together with Sumin @suminkim28 !
Excited to welcome Jacob @Kaestelhansen as a new Novo Nordisk Foundation post-doc to the lab!
Check out Sarah's new review on bidirectional promoters: sciencedirect.com/science/articl…
Excited to share Sarah's new review on BiDirectional Promoters (BDPs). Sarah discusses 6 molecular mechanisms that may account for unique transcriptional properties of BDP with a focus on noise regulation and co-expression: authors.elsevier.com/a/1jI5c,LqArU0…
Congrats to @proteinnns, Hui Si, @clee_bio, @liaulab on this new paper on LSD1 with imaging contributions from @DomenicNarducci sciencedirect.com/science/articl…
Lastly, our work highlights how resistance mutations can be invaluable discovery tools (see our review for more examples). Huge thanks to the team that made this work possible! Esp @proteinnns, Hui Si, @clee_bio, @Malvina_Pap, @hansen_lab & @liaulab (7/7) nature.com/articles/s4158…
Thrilled to welcome Masahiro Nagano to the lab as a new post-doc with fellowships from JSPS and HFSP - Masahiro is interested in understanding 3D genome structure and function relationships during germ cell differentiation.
