Chris Bailey
@cbailey_58
Budding haematologist and PhD student at the Crick looking into Cancer Evolution. Funded by CRUK.
A big thank you for highlighting our work 🙏🏽 🙏🏽
'Extrachromosomal DNA — Amping Up Cancer' in @NEJM! @lillian_siu & Trevor Pugh @PughLab highlight the encyclopaedia of ecDNA published in @Nature by @CharlesSwanton in collaboration with team eDyNAmiC 🔗nejm.org/doi/full/10.10…
A tweetorial for our work: we revealed an actionable therapeutic vulnerability of ecDNA by targeting hyperreliance on the replication stress (RS) regulation machinery in ecDNA-bearing tumour cells, which arises from pervasive transcription on ecDNA. 1/14 nature.com/articles/s4158…
Good news often goes unreported, especially if it happens gradually. That is the story of the war on cancer. Death rates are down substantially—and are likely to fall further. Future gains will come from three main sources econ.st/459V9Ec
A beautiful study led by my brilliant colleagues @oriol_pich @Elsa2Bernard that opens up the impact of tumour infiltrating clonal haematopoiesis
🚨Thrilled to share our latest work: “Tumor-Infiltrating Clonal Hematopoiesis” @NEJM - we investigated how age-related blood mutations impact cancer when they infiltrate tumors, with @Elsa2Bernard Maria Zagorulya, @PapaemmanuilLab @CharlesSwanton + more nejm.org/doi/full/10.10…
The potency of abnormal genetic fusion in chronic myeloid leukaemia in our latest study @Nature 👉🏽 nature.com/articles/s4158… This cancer is an oddity - one of the few single genetic “hit” cancers, a short trajectory (few years) from start to diagnosis, and explosive growth.
Now online in @CD_AACR: Spatial-Temporal Diversity of #ecDNA Shapes Urothelial Carcinoma Evolution & Tumor-Immune Microenvironment - by Wei Lv, Yuchen Zeng, Conghui Li, Yuan Liang, Birgitte Regenberg, Yonglun Luo, Chunhua Lin, Peng Han, and colleagues doi.org/10.1158/2159-8…
🔥New #review out! We explore how experimental models and high-throughput sequencing (or, all the ✨#omics✨) complement each other in #metastasis research. Bridging these approaches can unlock deeper insights into #cancer progression and #treatment
New online! Integrating model systems and genomic insights to decipher mechanisms of cancer metastasis bit.ly/3XC0xvy
4 DAYS until the abstract deadline for our ecDNA conference ⏰ Learn more: bit.ly/4bCgcAW
⏳ 14 MARCH ABSTRACT DEADLINE ⏳ If you'd like the opportunity to present your work alongside this 👇 stellar line-up of researchers at our ecDNA conference, ensure you submit your abstract by 14 March. Learn more: bit.ly/ecDNAConference
🚀 Our paper introducing ImmuneLENS, a new tool that measures T and B cell fractions from WGS data. This builds on our previous method, T cell ExTRECT, that used a signal from V(D)J recombination to measure T cells. Out today in @NatureGenet doi.org/10.1038/s41588… 🧵👇
We managed to get one last paper rdcu.be/d5gAe over the line before the new year🥂! We are pleased to share the first Nature Cell Biology paper from our lab functionally validating the role of a frequently occurring lung cancer driver, FAT1 in cancer evolution. 🧵1/13
1/ 🚨New paper on ecDNAs from our lab! We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! 🧵👇 nature.com/articles/s4158…
🚨So proud to present the first study from our @CCG_UCL group together with @CharlesSwanton @NnennayaKanu and led by @ojlucas with key collaboration @Ward__Sophie and fundamental support @Rija_Zaidi_ @abi_bunkum & many others Out in @NatureGenet 👇 doi.org/10.1038/s41588… 🧵👇
The AUTO4/librat1 trial has published results from initial 10 patients with PTCL treated with anti-TRBC1 CAR-T cells. Headline results: 40% CR including 2 in remission beyond 2 years, 3/4 CRs at highest dose. 1/ nature.com/articles/s4159…
Tweetorial below on the paper Coordinated inheritance of extrachromosomal DNAs in cancer cells, published yesterday in @Nature. ✍️ Written by @kinglhung, who's one of the first authors. Read 👇
Cancer cells often harbor oncogenes outside chromosomes on extrachromosomal DNA (ecDNA), which is unevenly inherited by dividing cells. Today we report in @Nature that collectives of ecDNAs are inherited together by dividing cancer cells. 1/ nature.com/articles/s4158…
⚪️🧬Un macroestudio liderado por @oriol_pich (#IRBalumni, ahora en @TheCrick) y @cbailey_58, revela diminutos círculos de ADN en las células de pacientes con algunos tipos de #cáncer, como el de mama #HER2+ —uno de los más agresivos— y el #glioblastoma en el cerebro. 🗣️…
Today #CancerGrandChallenges team eDyNAmiC and their international collaborators published 3️⃣ papers in @Nature 📣 They show the prevalence of ecDNA in cancer, identify fundamental mechanisms and an actionable target now being tested in the clinic. More: bit.ly/4dUMU00
Hot off the press!! 🔥 Check out our work on the origins and impact of ecDNA. This was a team effort involving multiple collaborators as one of a three part series on ecDNA in @Nature
ecDNA are rogue genetic material that amplify genes, contribute to treatment resistance and drive genomic heterogeneity. We report on the Origins and impact of extrachromosomal DNA today in @Nature nature.com/articles/s4158…
Very pleased to share our new online pre-print! We explore the spatial-temporal evolution of extrachromosomal DNA (ecDNA) in human glioblastoma. biorxiv.org/content/10.110…. A 🧵
Together with @CharlesSwanton, delighted to share that our new tool, MHC Hammer - which can detect different types of HLA disruption - mutation, loss, RNA repression and alt. splicing - is now out in #NatureGenetics and available to use…nature.com/articles/s4158…... 🧵below
🚨 Excited to share our latest paper in @CellCellPress identifying how under-replicated chromosomes in micronuclei become shattered by the Fanconi anemia pathway during mitosis. This work was led by @UTSWGradSchool student @JustinEngel17. 🧵 (1/13): cell.com/cell/fulltext/…