Peter Ly

Interested in how mitotic errors trigger micronuclei, #chromothripsis (chromosome fragmentation), and cancer genome instability? Check out our latest review @MolecularCell written by the talented duo of @Alice_0004 and @JustinEngel17. TL;DR below (1/6): cell.com/molecular-cell…

Our paper is now published @CurrentBiology! With our unique method to live image fertilized mouse eggs, we highlighted the importance of Ca2+ oscillations in maintaining the spindle position to ensure asymmetric cell division. Thanks to all the authors! sciencedirect.com/science/articl…

Happy to share that our recent work on the role of USP37 in counteracting the ubiquitylation and premature disassembly of stressed replisomes by TRAIP is now out. A fantastic collaboration with Olga Kochenova in @FrogWalterLab,@GS_Lab_Bham,@SPJacksonGroup nature.com/articles/s4146…

New preprint! We solve a mystery you didn't know existed. Mitotic cells lack new transcription but require ongoing translation. Interphase mRNA half life is only 2-4 hrs. So how do cells arrest in mitosis for hours without depleting their transcriptomes? biorxiv.org/content/10.110…

Congratulations to Justin Engel, Ph.D. student, on receiving the 2025 Nominata Award—UTSW’s highest graduate student honor—for his groundbreaking research on chromothripsis and its role in tumor growth and therapy resistance. Learn more: bit.ly/4kvD8EL #UTSWEdu

A transcription balance required for genome stability 🧬⚖️ Our work on RNA Pol II transcription speed control by the DNA helicase RECQL5 and the transcription-coupled DNA repair complex is now on ⁦⁦@NatureSMB⁩ #CryoEM #transcription nature.com/articles/s4159…

🚨 Hot off the press!!! Wanted to share this to celebrate the momentous achievement from the @GiuntaLab and for the human centromere / genomics communities as a whole... more posts to come next week but for now, happy Fourth & happy reading ❤️🧬💻 science.org/doi/10.1126/sc…

Delighted to share our latest work showing how cells that evade #senescence after CDK4/6 inhibition are primed to become aneuploid because of their increased size. Great work by super PhD student Aanchal Pareri biorxiv.org/content/10.110…

It's 102°F/39°C in New Haven—but 30 international experts have braved the heatwave to join us at @YaleMed for a 3-day workshop on chromosomal instability in cancer. Thank you to our workshop organizers, @roelverhaak, @markowetzlab, & Aurelie Ernst!

Want to better understand nuclear and genome organisation in various organisms, tissues, and cell states? Join @KarimMekhail , @altmeyerlab & Irene Chiolo at the upcoming 2nd Spatial Genome Organisation Conference this October! Talk Submission has been extended until 14th July,…

Wishing farewell to the first member of our lab, Qing Hu, as she embarks on a new adventure in the Laboratory Genetics and Genomics fellowship program at UCLA. Good luck Qing!

🚨Chemo treatment upgrade!🚨 Check out our approach to modernise chemotherapy treatment published today in @NatureGenet. From @CNIOStopCancer @TailorBio @CR_UK nature.com/articles/s4158… More details 👇

WE ARE HIRING: Postdoc Positions! Join us at UPenn in vibrant Philly, cutting-edge science, great city, amazing team. Please share and let's get in touch!

1/7 I am very excited to announce our🌹NEW PAPER OUT IN NATURE!🌹 Bimodal centromeres in pentaploid dogroses shed light on their unique meiosis With the Ritz and Kovařík labs we shed light on Rosa canina’s bizarre reproduction! nature.com/articles/s4158… #Meiosis4eva #Centromere

3 postdoctoral positions (1 comp, 2 experimental) available @ BaslanLab/Penn. We employ computation & functional biology to develop novel therapeutics, diagnostics & prognostic markers. Further detail below. Please share w/ trainees, colleagues & friends. nature.com/naturecareers/…

Just out! Aneuploidy alters cellular proteome and affects many functions. One protein, p62/ SQSTM1, becomes highly abundant and creates cytosolic bodies in cells with extra chromosomes. nature.com/articles/s4146…

Genomic analyses of mother–father–fetus trios after early pregnancy loss uncover contributions from chromosomal abnormalities and subtle genetic variants go.nature.com/4l849Pj

Endogenous tagging of BLM and PICH reveal their dynamic localization and functions throughout the cell cycle. New preprint: Mitotic BLM functions are required to maintain genomic stability biorxiv.org/content/10.110…

Really excited to share our new study, where we identified ZNF280A, a novel regulator of homologous recombination during DNA repair, linked to the human 22q11.2 distal deletion syndrome. A special shout out to @ThomasLClarke for leading the project! nature.com/articles/s4155…

Targeting DNA damage in ageing: towards supercharging DNA repair nature.com/articles/s4157… This new Review discusses approaches to pharmacologically mitigate the adverse effects of DNA damage to prevent mutation-driven cancers and mitigate age-related degenerative diseases

🚨🚨Paper out! 🚨🚨 Delighted to share our work, now published in @NatureGenet 🧬! shorturl.at/94s5S We identified a targetable, chromothripsis-associated genetic event in blast phase (BP) MPN, a particularly poor prognostic subtype of acute leukaemia. 1/n 🧵👇