Simone Zaccaria

🚨So proud to present the first study from our @CCG_UCL group together with @CharlesSwanton @NnennayaKanu and led by @ojlucas with key collaboration @Ward__Sophie and fundamental support @Rija_Zaidi_ @abi_bunkum & many others Out in @NatureGenet 👇 doi.org/10.1038/s41588… 🧵👇

Are metastatic #cancers more like their normal origin or target tissues? Our work in @ScienceAdvances systematically compares the #transcriptomics of primary and metastatic #tumors to healthy tissues in a #PanCancer, genome-wide manner! #metastasis 🧵1/10 shorturl.at/Uc4xx

We're hiring a sequencing technician for #TRACERx! Interested in cutting-edge genomic tech to understand cancer? 👉 tinyurl.com/myh4un9j #Genomics #CancerResearch Join our world-leading teams at @TheCrick & @uclcancer

🚨 We're hiring a sequencing technician in #TRACERx! Join world-leading teams at @TheCrick & @uclcancer, working at the forefront of cancer research. Interested in cutting-edge genomic tech to understand cancer? Apply now! 👉 ucl.ac.uk/work-at-ucl/se… #Genomics #CancerResearch

We're a month out from #ISMBECCB2025!  You can now access the abridged agenda, downloadable schedules, poster listings, and SciFinder search tool links directly from the homepage: iscb.org/ismbeccb2025/h… Click the link you need, or use the Programme &  Agenda menu for more…

Be a part of ISMB/ECCB 2025: Shape the future of computational biology. Attend in-person in Liverpool or virtually for live sessions, Q&A, and exclusive networking. Elevate your research at the forefront of bioinformatics!

Huge congratulations to @LucreziaPatruno from @CCG_UCL for being awarded one of the best abstract awards at AI in Oncology in Paris, we are so proud! Join ISMB to hear her full story on the next advances in call CNAs from single cell seq!

1 in 2 people will get cancer in their lifetime. Our @CCG_UCL 'll still run @CR_UK Muddy Race also this May to highlight the importance of funding cancer research @CRUKresearch and improving patient outcomes Please support us if you can! #RaceforLife 👉 fundraise.cancerresearchuk.org/team/computati…

Now the incredible Mariam Jamal-Hanjani presenting data from the TRACERx Peace cohorts defining the metastatic cascade in Nsclc ⁦@CRUKresearch⁩ ⁦@uclcancer⁩ ⁦@TheCrick⁩

Excited to see our @NEJM paper out on tumor-infiltrating CH, tumor evolution, and patient outcomes. A privilege to work w/ friends @oriol_pich and Maria Zagorulya with invaluable support from @PapaemmanuilLab and @CharlesSwanton @MSKCancerCenter @TheCrick @GustaveRoussy 👇👇

🚨Thrilled to share our latest work: “Tumor-Infiltrating Clonal Hematopoiesis” @NEJM - we investigated how age-related blood mutations impact cancer when they infiltrate tumors, with @Elsa2Bernard Maria Zagorulya, @PapaemmanuilLab @CharlesSwanton + more nejm.org/doi/full/10.10…

There’s much more in the paper: 👉 Single-cell genomic data from patients with TI-CH @AdamMead_Oxford 👉 TI-CH in metastases, including autopsy samples from the PEACE study @CR_UK 👉 Functional experiments with the help of many labs, including Dominique Bonnet's @TheCrick

🙏 I am so grateful to @uclcancer and all my colleagues at the institute for their constant and incredible support 🙏 Thanks to @EMBO and @EMBO_YIP for this great opportunity; excited for the journey ahead!

Delighted to introduce our new spatial transcriptomics tool, SpottedPy, recently published @GenomeBiology, allowing the identification of tumour hotspots at different scales and the exploration of distances and overlap with tumour microenvironment niches: genomebiology.biomedcentral.com/articles/10.11…

#TumorEvolution reconstruction is heavily influenced by algorithmic & experimental choices—this In the Spotlight commentary by @Rija_Zaidi_ & @ZaccaSimo highlights a recent @NatureBiotech paper by @TheBoutrosLab, @VanLooLab, @kellrott, @MaxGalder, et al. bit.ly/3VAMRQs

🚨Very proud of this commentary led by @Rija_Zaidi_ reasoning on the method and experimental design impact on cancer evolution understanding, motivated by the outstanding work of @TheBoutrosLab, @VanLooLab, @kellrott et al Orig. work 👉 doi.org/10.1038/s41587… Our Commentary 👇

How much do algorithmic and experimental choices drive the accuracy of reconstructing tumour evolution? In this @CR_AACR commentary, @ZaccaSimo and I discuss a recent @NatureBiotech benchmarking paper exploring this question:

Huge congratulations to our faculty member @ZaccaSimo, who has been selected as an @EMBO Young Investigator. This highly competitive programme supports a prestigious cohort of young group leaders through funding, training and mentorship. Find out more: embo.org/press-releases…

Congratulations! Simone is on of our Career Development Fellows and now part of the @EMBO Young Investigator Programme that supports young group leaders in Europe and beyond through funding, training and mentorship.

🎉 So hugely honoured and happy to be selected for the @EMBO Young Investigator Programme 2024 @EMBO_YIP! Such an exciting opportunity for our group @CCG_UCL and so grateful for the support of @uclcancer @uclnews @ucl @CRUKCOLcentre @TheCrick & our funders @CRUKresearch @CR_UK

We are so grateful to @qianthefirst for this outstanding @NatureGenet News&Views piece highlighting our recent SPRINTER work and framing it so beautifully within the literature. A truly valuable resource! 🙏 Read it here👉 doi.org/10.1038/s41588… 🧵Dive into SPRINTER's work 👇