aydanszeto
@aydanszeto
Immunologist @MRC_LMB | Views are my own | he/him 🏳️🌈| I work towards manipulating the Yin and Yang of inflammation #Findmeonbluesky 🥏☁️@aydanszeto
Thrilled to share our newest study in @ScienceMagazine. We created Boolean mice and CRISPR screened the heck outta ILC2s 🧵 1/ @MRC_LMB @wellcometrust @croucherFDN
I'll soon be recruiting a postdoc fellow to join us @ MRC LMB to continue developing our programme to understand neuroimmune modulation 🧠🔬🧬🩸🫁 If you're interested in joining us check also @MSCActions, @wellcometrust & www2.mrc-lmb.cam.ac.uk/recruitment/ri… & DM'me youtu.be/-oEXpyjWBFU?si…
Direct effect of Abx on mammalian cells 😱
🚨🚨I’m excited to present our lab’s new paper where we tried to provide a mechanistic explanation for the link between antibiotic use and risk of developing inflammatory bowel diseases (#IBD). A 🧵/1 science.org/doi/10.1126/sc…
(1/4) Our newest discovery on B-cell memory, just published @ImmunityCP: the development of memory B cells from germinal centers requires IL-9 derived from T cells, which instructs MBC development through the action of transcription factor ZBTB18. cell.com/immunity/fullt…
Excited to share our new paper in @JExpMed 🎉 We show that NK cells use autocrine TGF-β1 signalling to establish tissue residency, form a highly cytotoxic subset, and protect the tissue against viral persistence. rupress.org/jem/article/22…
From June '24: The transcription factor Mef2d augments type 2 immune responses during allergic lung inflammation, regulating differentiation of Th2 and ILC2 cells. buff.ly/3BdtFkS Work from @aydanszeto et al. #Immunology #ILC2s @ScienceMagazine
Did a dendritic cell researcher come up with this name 😂
The Stanford Immunology Review Program for Applicants (SIRPA) assists individuals applying to the Immunology PhD program. Receive a round of feedback on statements of purpose and participate in a mock interview. Registration open from Oct. 4-31, 2024: tinyurl.com/apply2sirpa2024
Super important issue in the mouse research community to address. Carefully consider and reject all alternative hypotheses, and don’t just assume!
Passenger mutations in KO mice can influence gene expression & impact experimental results 3 studies this month highlight this issue - Nlrp3 (inflammasome) doi.org/10.1038/s41418… - Ackr1 & Ackr2 (chemokine) doi.org/10.1093/jleuko… doi.org/10.1093/jleuko… Check your KO mice
Fascinating study on the potentially beneficial role of IL-4 signalling on CAR-T products to persist post-transfusion. Wouldn’t have thought type-2 immunity helps with anti-tumour response, but human immunology is so different and full of surprises 😌 nature.com/articles/s4158…
If you're an American passionate about science & thinking to cross the pond to do your PhD consider applying to the @MRC_LMB PhD international programme @LMB_PhD with a @Gates_Cambridge scholarship! 👇👇 Deadline Oct 16th! Exciting projects!!
Passenger mutations in KO mice can influence gene expression & impact experimental results 3 studies this month highlight this issue - Nlrp3 (inflammasome) doi.org/10.1038/s41418… - Ackr1 & Ackr2 (chemokine) doi.org/10.1093/jleuko… doi.org/10.1093/jleuko… Check your KO mice
Amazing opportunity to build cutting edge instruments with talented people at @MRC_LMB, Cambridge UK Help us make microscopy as high-throughput as flow cytometry, whilst retaining resolution 😎
Passenger mutations in KO mice can influence gene expression & impact experimental results 3 studies this month highlight this issue - Nlrp3 (inflammasome) doi.org/10.1038/s41418… - Ackr1 & Ackr2 (chemokine) doi.org/10.1093/jleuko… doi.org/10.1093/jleuko… Check your KO mice
When reviewer 2 asks for a single cell RNA-seq just because we could, but adds nothing to the paper
I'm elated to share that my postdoc work is now online @Nature! nature.com/articles/s4158… If you are interested in neuroimmunology (gd T cells, IL-3, sensory neurons) or allergy (allergic itch and initiation of the allergic immune response), this paper is for you! (1/16)
Congratulations on adding yet another piece of the puzzle on how dermal type-2 immunity is initiated! The skin is truly a unique barrier site full of goddamn (GD) surprises
In our new paper out today nature.com/articles/s4158…, we started with a simple hypothesis - inspired by work on IL-4/IL-13 from @itchdoctor - that an innate immune cell might control sensory neuronal detection of allergens via a secreted factor. (1/11)
Ok who has tips for taking parental leave as a PI, specifically for lab management? (Pls rt)
Thrilled to announce that our latest research at @CIML_Immunology showing that lymphotoxin acts as an inhibitory checkpoint of thymic Treg development is out in @NatureComms Link: rdcu.be/dSGOW @Irlalab @AlexiaBorelli @RafaJArguello #Treg #Thymus #Tcells #Immunology
One of my pet peeves 🙂↕️ T-2 immunity can be anti-T1/anti-T17 in some contexts but my nasal mucosa during spring time is far from being “anti-inflamed”.
I'm reading SUCH a cool paper, but I just can't!!! NOOOOOOOO Th2 is NOT anti-inflammatory! Th2 is NOT anti-inflammatory! Please help me shout this from the rooftops. Th2/allergic-type responses are highly "inflammatory", just with different disease manifestations than Th1.