Magali IRLA Lab
@IrlaLab
Our lab studies the mechanisms of thymic T-cell tolerance. We develop innovative strategies to regenerate the thymic function and treat autoimmune diseases.
🎉🎉🎉 Very happy to see my review out in @AnnualReviews on thymic T cell selection ! If you like T cells check it out !🎉🎉🎉 annualreviews.org/doi/abs/10.114…
Vitamin D Deficiency in Childhood Linked to Higher Autoimmune Risk A recent study has found that vitamin D deficiency during childhood accelerates the aging of the thymus, an organ essential for developing a healthy immune system. The thymus helps train immune cells to…
@IrlaLab and collaborators reveals that RANKL therapy reverses age-related thymic decline, recovering immune health in older adults by restoring youthful T-cell responses to vaccines and tumors. Check their study in @ScienceTM. science.org/doi/10.1126/sc…
New work connects #immunosenescence and the decline of the #thymus during aging with a drop in the ligand #RANKL—and shows RANKL treatment restores T cell production and rejuvenates immune responses in aged mice. @IrlaLab @JrmyCSantamaria @CIML_Immunology scim.ag/3ZAqihe
One of the alluring and theoretical strategies for extending healthspan and longevity is to rejuvenate the thymus gland, promote an intact immune system. Now there's a way to do that in aged mice. science.org/doi/10.1126/sc… @ScienceTM
I remember being blown away when @IrlaLab showed me these data @CIML_Immunology 🤯 - Exogenous RANKL substantially reverts thymic involution and improves T cell function in aged mice @ScienceTM science.org/doi/10.1126/sc…
A new study on @ScienceTM finds RANKL treatment can restore thymic function in aged mice and improve their T cell-mediated immune responses. #aging @JrmyCSantamaria, Dr.Magali Irla @IrlaLab, Antoine Toubert of @univ_paris_cite, et al. science.org/doi/10.1126/sc…
Congrats to @AlexiaBorelli for successfully defending her PhD thesis at @CIML_Immunology ! Her work has advanced our understanding of Foxp3+ Treg development and thymic recirculation, with 2 first-author papers in @NatureComms and Cell Mol Life Sci. #Treg #Thymus #Immuno #CIML
Sex-biased human thymic architecture guides T cell development through spatially defined niches: Developmental Cell cell.com/developmental-…
Review by Pala et al. highlights how novel cutting-edge technologies, incl. high-resolution imaging, single-cell omics & organoid cultures, have improved our understanding of human #thymus biology hubs.la/Q02TfwHP0 📘In our #Autoimmunity collection: hubs.la/Q02TfzFt0
New issue online! This beautiful cover depicts work from @maxim_artyomov, Pavla Bohacova, Marina Terekhova &co identifying CD38 expression as a marker of recent thymic emigrants. Image credit: Fishy Frog cell.com/immunity/issue…
LAI will host a seminar on Wednesday 16th of October at 11 a.m. in the Amphi 12, Bat B - Cyril Favard (IRIM) "Mechanics and Kinetics of HIV-1 assembly in living T cells: insights from single/few molecule dynamics"
Thrilled to announce that our latest research at @CIML_Immunology showing that lymphotoxin acts as an inhibitory checkpoint of thymic Treg development is out in @NatureComms Link: rdcu.be/dSGOW @Irlalab @AlexiaBorelli @RafaJArguello #Treg #Thymus #Tcells #Immunology
Lymphotoxin is first inhibitory checkpoint of thymic Treg development that fine-tunes the Foxp3lo Treg precursor pathway by limiting IL-4 availability @IrlaLab @AlexiaBorelli nature.com/articles/s4146…