Colin Sparano

Excited to share our new paper in @JExpMed 🎉 We show that NK cells use autocrine TGF-β1 signalling to establish tissue residency, form a highly cytotoxic subset, and protect the tissue against viral persistence. rupress.org/jem/article/22…

B cell depleting therapies effectively treat #MultipleSclerosis, yet our understanding of why remains limited. How does loss of B cells impact the immune system in MS? See our multicohort study employing high-dimensional single-cell immunophenotyping: cell.com/cell-reports-m…

We are delighted to share our new review article from Nils Müller "To kill or not to kill - the role of the tumor microenvironment in shaping group 1 ILC functions" now in @Official_SSIM where we discuss the flavors of group 1 ILCs in different tumors doi.org/10.1016/j.smim…

Our March cover hubs.la/Q038CHPl0 shows an immunofluorescence staining of salivary gland from MCMV-infected mice 16 days after infection. @TuguesLab (hubs.la/Q038CP8T0) show that autocrine TGF-β1 drives tissue-specific differentiation and function of resident NK cells

Are you an immunologist interested in spatially-resolved single cell technologies and generative modeling but dont know where to start? Check out our @EurJImmunol review with Avital, Hosna, Robert Zeiser, @IdoAmitLab, @YosefLab & @WertheimerT onlinelibrary.wiley.com/doi/10.1002/ej…

Check out our new review article on spatially resolved single cell technologies and generative modeling and their application in immunology research. Fun collaboration with Avital, Hosna, @YosefLab, @IdoAmitLab and @FlorianIngelfi1 onlinelibrary.wiley.com/doi/10.1002/ej…

Myers, Reilly, & Brossay @BrownUniversity discuss work by @csparano93, @SolisSayago et al. @TuguesLab (hubs.la/Q03155TM0) which shows that tissue-resident NK cells produce TGF-β1 themselves to establish and maintain residency in glandular tissues. hubs.la/Q03157gF0

.@csparano93, @SolisSayago et al. @TuguesLab @UZH_en reveal that tissue-resident NK cells produce their own TGF-β1 to sustain residency in glandular tissues, providing local antiviral protection. hubs.la/Q0302Wml0 #inflammation #LymphocyteBiology #InfectiousDisease

Check out our latest research revealing the role of hepatic iNKT cells in promoting colorectal cancer liver metastasis!

If you’re excited about working at the intersection between wet and dry lab to better understand relapse after allo-HCT, consider joining our group for a PhD 😊 uniklinik-freiburg.de/karriere/stell…

Thrilled to share our latest collaboration with @Becherlab: "IL-23 stabilizes effector Treg program in tumors" by @WertheimerT and @PascaleZwicky et al. out now in @NatImmunol. Check out the great tweetorial of the @Becherlab !

Please check out our paper published in @NatureMedicine on our Phase I / II trial with cord blood CAR19/IL15 NK cells. We report promising 1 year PF and OS rates of 32% and 68% in patients with relapsed / refractory B cell malignancies (with a median of 4 prior lines of…

Happy to see this out @ImmunityCP: cNK cells establish tissue residency upon acute skin infection. Tcf7+CD69+ trNK resemble CD56bright NK cells in human tissues, and mediate rapid secondary responses. Thanks to the fantastic @Wue_SI team + all collabs! cell.com/immunity/fullt…

Interested in Tissue Homeostasis and Immunity? NK cells and ILCs? join this fantastic nk-symposium.org with lots of exciting science from @SunLab_Official, @EricVivier1, @maini_lab, @LMackayLab, @bjorkstrom_lab, @Molofsky_lab, @Hepworth_Lab...

Authored by Andrew G. Soerens et al, we show that #Tcells are capable of proliferating in response to iterative stimulation for over 10yrs! And produce enough progeny to occupy a volume 30,000x the Earth's volume! @Nature nature.com/articles/s4158…

Pleasure working with @RomagnaniLab on this @NatureNV article, highlighting 3 exciting recent @Nature papers which shed new light on how gut Tregs are induced by RORgt+ APCs. How regulatory T cells are primed to aid tolerance of gut bacteria nature.com/articles/d4158…