ᒍOᕼᗩᑎ ᗪᑌᑕᕼEᑎE

Antibodies don't work. NLRP3 is by far the most studied inflammasome — yet <30% of commercial antibodies were specific. Only 4 of 14 tested antibodies detected NLRP3 specifically. Antibodies must be validated before use. Full report by @YCharOS1 zenodo.org/records/116239…

After 15 years of controversy, @ScienceMagazine retracts ‘arsenic life’ paper retractionwatch.com/2025/07/24/sci…

Congrats @CincyImmunology @AndypedsId @HAFeldman17 @VijayVelu77 @tuazonjasmine @allisonyan @_Ayad_Ali Refined cell transfer model reveals roles for Ascl2 and Cxcr3 in splenic localization of mouse NK cells during virus infection academic.oup.com/jimmunol/advan… @J_Immunol

We should always strive to acknowledge problems and improve. We should also acknowledge when things work. 𝐘𝐞𝐬, 𝐦𝐚𝐧𝐲 𝐫𝐞𝐬𝐞𝐚𝐫𝐜𝐡 𝐫𝐞𝐬𝐮𝐥𝐭𝐬 𝐚𝐫𝐞 𝐫𝐞𝐥𝐢𝐚𝐛𝐥𝐞 & 𝐫𝐞𝐩𝐫𝐨𝐝𝐮𝐜𝐢𝐛𝐥𝐞. nature.com/articles/d4158…

It is difficult to get a man to understand something, when his salary depends on his not understanding it. — Upton Sinclair I could never have known so well how paltry men are, and how little they care for really high aims, if I had not tested them by my scientific researches.…

"Experts share how academic publishing must evolve to meet modern scientific and societal challenges." technologynetworks.com/tn/articles/wh…

Quality of scientific papers questioned as academics ‘overwhelmed’ by the millions published | Peer review and scientific publishing | The Guardian theguardian.com/science/2025/j…

Remembering Mario Biagioli, who articulated how scholarly metrics lead to fraud. retractionwatch.com/2025/07/03/rem…

We retrospectively analyzed the reproducibility of 400 papers in the field of #Drosophila immunity. Irreproducibility was rather low. High-impact journals, top institutions and PI training influence replicability levels. #Reproducibility #LifeSciences

Differences of the 6N and 6J Substrains of C57BL/6 Mice in the Development of Experimental Autoimmune Encephalomyelitis onlinelibrary.wiley.com/doi/10.1002/mc…

A comparison of mouse vs human tumor microenvironments shows a major difference. Mouse TMEs have more macrophages, while human TMEs have more T cells. Chemokine expression patterns are also different. Learn more: biorxiv.org/content/10.110…

5. A better method to remove clots nature.com/articles/s4158…

If you don’t have time to take a walk, then you don’t have time to do science. Charles Darwin would take two walks every day on his "thinking path", not as a break from science, but as a crucial part of it.

In a new study, researchers find that the chemokine CXCL12 can support the production of red blood cells in mice, suggesting that this pathway could be investigated for the treatment of disorders related to red blood cells. Learn more in @SciSignal: scim.ag/4kTxFZz

#FluorescenceFriday & Erythroblast Erythroblast stimulated with CXCL12, stained for CXCR4 (green) and nuclei (blue). Captured via Correlative Light & Electron Microscopy by @JemimaBurden Learn more: scim.ag/4kTxFZz @GutjahrJulia @RotAntal @ScienceMagazine @scisignal

In a new study, researchers find that the chemokine CXCL12 can support the production of red blood cells in mice, suggesting that this pathway could be investigated for the treatment of disorders related to red blood cells. Learn more in @SciSignal: scim.ag/4kTxFZz

A team finds that the #chemokine CXCL12 can support the production of #RedBloodCells in mice, suggesting that this pathway could be investigated for the treatment of disorders related to red blood cells. @stevenduke @GutjahrJulia @QMULWHRI scim.ag/446wONU

science.org/doi/10.1126/sc… We describe the hitherto overlooked expression of CXCR4 in erythroblasts, which do not migrate in response to CXCR4 ligation by CXCL12. Instead, CXCR4 localises to the nucleus and mediates alternative responses in erythroblast maturation and enucleation

Not all chemokine signaling is about cell migration! In mouse erythroblasts, CXCL12-bound CXCR4 enters the nucleus to control gene transcription, trigger calcium bursts, and drive red blood cell formation—especially enucleation. 🔗 science.org/doi/10.1126/sc… #chemokine #CXCR4

Although chemokines are known for their role in cell migration, new work in mice shows that CXCL12 also promotes the differentiation of #erythroblasts by promoting CXCR4 signaling and activity in the nucleus. @stevenduke @GutjahrJulia @QMULWHRI scim.ag/446wONU

CXCL12-stimulated intracellular and nuclear CXCR4 signaling mediates erythroblast enucleation to generate red blood cells @scisignal @GutjahrJulia @RotAntal science.org/doi/10.1126/sc…