Ajay Labade

Thrilled to announce that our work on Expansion In Situ Genome Sequencing (ExIGS) is now published in @ScienceMagazine! ExIGS allows us to sequence DNA and image proteins with super-resolution directly within single cells. science.org/doi/10.1126/sc…

This microscope can simultaneously sequence an individual cell’s DNA and pinpoint the location of its proteins with high resolution — all without having to crack the cell open and extract its contents go.nature.com/3Y5jqGG

In 2021, we predicted the opportunity for "many-fold improvements in yield and resolution ... through integration of IGS with Expansion Microscopy". Now @ajaylabade31 @z_chiang @CarolineComenho @JD_Buenrostro and colleagues have delivered 10x better intact-cell genome sequencing!

Super excited that Expansion In Situ Genome Sequencing (ExIGS) is out now in @ScienceMagazine ! Check out the paper to see what can be revealed by sequencing the genome in its native position and high-res imaging its interactions with nearby proteins. science.org/doi/10.1126/sc…

A new combination technique enables DNA sequencing and high-resolution imaging in intact cells — offering new insights into progeria and aging. broad.io/expansion-in-s… @JD_Buenrostro @insitubiology @ajaylabade31 @CarolineComenho @z_chiang @ScienceMagazine

I’m excited to share my work over the last few years with @JD_Buenrostro! Chronic inflammation creates an epigenetic memory in colonic stem cells, priming them for tumor growth: tinyurl.com/ColitisNagaraj…. Here’s a walkthrough of what we found (🧵)

Super excited to share our new study from the @JD_Buenrostro Lab in @Nature! We developed a computational method for tracking transcription factor and nucleosome binding using single-cell ATAC-seq and deep learning. Paper: nature.com/articles/s4158…

Protein shapes can now be studied using ONE🔬, a combination of ExM and #fluorescence fluctuation analysis. Happy to have contributed to this paper published in @NatureBiotech with many great scientists. Special thanks to @AliHShaib and Silvio Rizzoli. nature.com/articles/s4158…

Thrilled!

Thanks, Zack! I'm excited to contribute to the future of biology through these/more futuristic technologies that are set to transform human health. Feeling fortunate to work with the pioneers of IGS&ExM: @Andrew_C_Payne, @PaulReginato, @JD_Buenrostro, @insitubiology, @eboyden3

Blown away by the response to our preprint - I always forget one of the best parts of science is seeing others genuinely excited about your work Thought it might be a fun time to repost my 2022 essay on where spatial technologies may go in the future: chianglab.bio/2024/09/26/spa…

So excited to finally share ExIGS, a new tech we (@z_chiang @ajaylabade31 @JD_Buenrostro) developed to combine spatial genomics with expansion microscopy

7 years ago, I met a junior fellow named @JD_Buenrostro who blew me away with a vision of futuristic genomic technologies Today, we (@ajaylabade31, @carolinecomenho) are excited to share our first steps into that future: Expansion in situ genome sequencing 1/