Abby Thurm
@abbythurm
MD/PhD Student @StanfordMed | thinking about all things RNA in gene expression @BintuLab | B.S. @uclachem | she/her
Do human RNA-binding proteins have modular regulatory domains that downregulate RNA lifetimes? Our preprint @BintuLab studying this question is now out on bioRxiv, where we indeed identify small domains in RBPs that potently induce RNA degradation! biorxiv.org/content/10.110… (1/9)
Many proteins bind RNA, yet we still don’t know what RNAs most bind because methods map one RBP at a time. In @CellCellPress, with the Jovanovic lab, we describe SPIDR – a method for mapping the RNA binding sites of dozens of RBPs in a single experiment. sciencedirect.com/science/articl…
Our preprint describing the Range Extender element, which is required and sufficient for long-range enhancer activation at the Shh locus, is out in @Nature. nature.com/articles/s4158…
How do enhancers work over distances that sometimes exceed megabases? Excited to share our work led by @gracecbower where we uncover a unique sequence signature globally associated with long-range enhancer-promoter interactions in developing limb buds: biorxiv.org/content/10.110… 1/
For innate immune cells, the lack of diverse receptor rearrangements has prevented the study of clonal evolution of the innate immune system in human tissues and tumors. With @satpathology and @caleblareau, I’m delighted to share my PhD work that tackles this challenge:
Clonal lineage tracing of innate immune cells in human cancer biorxiv.org/content/10.110… #biorxiv_genomic
🚨 New Preprint 🚨 A continuous landscape of signaling encodes a corresponding landscape of CAR T cell phenotype How can we tune JAK/STAT signaling to create better immune cell therapies? doi.org/10.1101/2025.0…
It's almost time for our brand-new EMBL Conference 'The expanding world of RBPs' to start! 🥳 Follow along for live updates here and on Bluesky (bsky.app/profile/events…), and check out our event reporter @AyushiRehman for some first-hand participant insights! 👩🔬 #EMBLRBP
Very proud of my graduate students @adelefrancisxu and Zijian Zhang & key members of our lab and collaborators @GarryPNolan & Sharon Pitteri lfor the incredibly hard work to characterize subcellular ribosomes. science.org/doi/10.1126/sc…
Our work using thermodynamic principles to link in vitro TF affinities and kinetics to single-molecule chromatin states in cells is now on bioRxiv! Amazing effort by first author @juliaschaepe in @WJGreenleaf lab: biorxiv.org/content/10.110… @Stanford @scilifelab @Stockholm_Uni [1/9]
It's finally out! :)
Incredibly excited that our paper linking single molecule states of TF binding to gene expression using quantitative thermodynamic models is out in Nature today. An amazing collaboration with the Bintu Lab. Congrats to Ben, Michaela, and Julia! nature.com/articles/s4158…
I’m excited to share the first preprint out of the Altemose Lab! This stems from a heroic effort by Dr. Matt Franklin @matt_franklin_ (who's on the job market!), who made surprising discoveries regarding some of the most mysterious regions of the genome. biorxiv.org/content/10.110…
I’m so excited to launch my independent career in a big way with the @NIH_CommonFund!! This is truly a testament to the wonderful mentors in my life and I hope I make them proud!
BREAKING NEWS The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.
I’m amped to share our new work to decrypt transcriptional repressors, now on bioRxiv: biorxiv.org/content/10.110… We paired deep mutational scans with machine learning to predict and even tune repressor activity. (1/8)
Check out our collaboration with @Cheers2LO on a SEISMICgraph tool for chemical probing data analysis and showing that RNA chem mods kill riboswitch function biorxiv.org/content/10.110… . RNA structure aficionados give it a try !
Our latest work is now published in @MolecularCell! We discovered new RNA-binding zinc finger proteins and demonstrated their functions in RNA splicing, stability, and polyadenylation. Congrats to 1st author @MayaGosztyla and our fantastic collaborators. cell.com/molecular-cell…
🚨Excited to share another paper in @MolecularCell!🚨 In collab w/ @Columbia’s Marko Jonvanoic, Lena Street, & @HoustonMethodist’s Kris Brannan, we mapped RNA-aware, RBP-centric protein-protein interactions (PPIs) across the mRNA life cycle in human cells! cell.com/molecular-cell…
They call me 007 0 publications 0 funding 7 more years to finish my PhD
I am excited to share that I will be starting as a tenure track Assistant Professor in @CoulterBME at @GeorgiaTech in the upcoming year. I am very grateful of the unwavering support of my postdoctoral mentor, @SynBioGaoLab , and my PhD supervisor, Michael Sefton.