Bashor Lab
@BashorLab
Bashor Lab in Houston, Texas | Mammalian Synthetic Biology et al.
🚨NEW PUBLICATION ALERT🚨: In a paper out today in @ScienceMagazine we describe a way to build synthetic phosphorylation circuits with customizable sense-and-response functions in human cells. Check it out at science.org/doi/10.1126/sc…. 🧵1/n
Happy Sunday to all! This morning, we are excited to share Chase’s work developing a simple, scalable method to assemble 100s-1000s of custom genes from oligo pools using standard lab tools! (Small 🧵 below)
How do chromatin remodelers use #IDRs to find their TF binding partners? Check out San’s tweetorial about SWI/SNF (cBAF) subunit ARID1A and β-catenin, now online at Mol Cell
Excited to share our new Molecular Cell paper! We show that β-catenin is an adaptor that links canonical BAF (cBAF) with binding partners via IDR-domain interactions. (1/7) cell.com/molecular-cell…
Have you always wanted to take a protein from its native context and make it work elsewhere? Our novel sampler computationally “cytosolize” a secreted enzyme while maintaining its structure, generalizable to other multi-objective guided generation tasks biorxiv.org/content/10.110…
Online now @ Cell is the yeast multicellular engineering paper from @DrFankangMeng - the fruits of his productive PhD. He developed modular synthetic biology tools to bring multicellular behaviours to yeast - adhesion, juxtacrine signalling and more. cell.com/cell/fulltext/…
Synthetic biology could enable new types of programmable therapeutics. Our new preprint introduces synthetic protein circuits that selectively trigger cell death in Ras-mutant cancer cells, with interesting advantages compared to existing approaches. biorxiv.org/content/10.110…
How do we improve nanoparticle delivery to tumors? Please see our recent publication detailing a dual pH-responsive micelle with improved tumor biodistribution. We engineer a STING-activating micelle (PC7A) using a carrier polymer strategy for immunoRx pubs.acs.org/doi/10.1021/ja…
🚨 New Preprint 🚨 A continuous landscape of signaling encodes a corresponding landscape of CAR T cell phenotype How can we tune JAK/STAT signaling to create better immune cell therapies? doi.org/10.1101/2025.0…
This is your last chance to showcase your work at this year's mSBW. The program offers a unique platform to share your latest research and connect with experts. Submit your abstract for a poster presentation today — Limited spaces left! bit.ly/3WwfChK #mSBW2025 #research
🚨 Our lab just rewrote life‘s operating system! Together, we’ve built Syn57 - an E. coli with a synthetic genome running on a 57-codon genetic code! biorxiv.org/content/10.110… #SyntheticBiology #Syn57 #PhD #GeneticCode #GenomeEngineering #Biosecurity #FutureOfBiology
Thrilled to share our preprint led by @chenxinyi924 on programmable molecule delivery via engineered trogocytosis called TRANSFER! a 🧵 @Stanford_ChEMH @bioe_stanford
Spatial genomics of AAV vectors reveals mechanism of transcriptional crosstalk that enables targeted delivery of large genetic cargo go.nature.com/4kFUnEO
Unlike a lot of other universities right now, we are still hiring for new faculty here at Imperial in London 🎉🚨🇬🇧🫖 If you want to come and run a research group in the theme of bioengineering then apply to be my colleague before the end of April. imperial.ac.uk/jobs/search-jo…
Protein function often depends on protein dynamics. To design proteins that function like natural ones, how do we predict their dynamics? @HWaymentSteele and I are thrilled to share the first big, experimental datasets on protein dynamics and our new model: Dyna-1! 🧵
Information storage across a microbial community using universal RNA barcoding go.nature.com/440gL5E
Bio-based production of poly(ester amide) for the first time. Great work, Dr. Chae and co-authors. Biosynthesis of poly(ester amide)s in engineered Escherichia coli Nature Chemical Biology rdcu.be/edUDv nature.com/articles/s4158…
Fresh in @NatureBiotech! We developed a synthetic biology tool for tracking gene transfer in microbial communities and applied it to study plasmid hosts in a wastewater microbiome. Awesome collab with @ChappellLab & @JoffSilberg and incredible students. nature.com/articles/s4158…
Thrilled to share our new preprint on using a new type of microbial memory to track horizontal gene transfer in environmental microbial communities. Amazing collaboration with @ChappellLab and @JoffSilberg labs. biorxiv.org/content/10.110… (1/n)
Rice Innovation announced its most recent awardee of the One Small Step Grant: @RiceBIOE NSF Graduate Research Fellow AJ Walters. Funding supports his therapeutics solution company Chassis.Bio, which develops tech to target neuroinflammation. news.rice.edu/news/2025/rice…
So we beat on. Gene/cell therapies often use proteins that could be recognized/rejected as non-self by our immune system. We combine algorithms to build proteins that are therapeutically relevant and can masquerade as our own parts doi.org/10.1101/2025.0…
Rice bioengineer Gang Bao and collaborators at Baylor College of Medicine have developed a new gene-editing strategy that dramatically boosts the effectiveness of gene therapies in the liver. bit.ly/4gAHOaA
New research in Science represents a notable step forward in designing enzymes from scratch. With a new approach, researchers designed an enzyme that uses a covalent intermediate to catalyze a two-step reaction, analogous to what many proteases do when breaking apart proteins.…